Group items tagged Forums - Diigo In Education

The biosinthetic path that allow Psilocybin to be produced by mushrooms is as follow:
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The several analogyes with triptophan aminoacid, with whom psilocybin has common origines are probably at the base of psilocybin ability to induced psychedelich alteration on humans.
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Amino acids, including tryptophan, act as building blocks in protein biosynthesis. In addition, tryptophan functions as a biochemical precursor for many compounds like serotonin Serotonin (a neurotransmitter), synthesized via tryptophan hydroxylase. Serotonin, in turn, can be converted to melatonin (a neurohormone), via N-acetyltransferase and 5-hydroxyindole-O-methyltransferase activities
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it's been noticed that psilocyn can indirectly raise dopamine concentration withing the basal ganglia.
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Almost 50% of oral psilocybin is absorbed by stomach and gut; from here is lead to liver, where it's converted in psilocin, pharmacologically active form, that can furtherly be glucoronated and escreted with urine or converted in other psilocinics metabolites.
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In rats, the median lethal dose (LD50) when administered orally is 280 milligrams per kilogram (mg/kg), approximately one and a half times that of caffeine. When administered intravenously in rabbits, psilocybin's LD50 is approximately 12.5 mg/kg
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traces of the compund can be detected in unine even after 7 days.
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Clinical studies show that psilocin concentrations in the plasma of adults average about 8 µg/liter within 2 hours after ingestion of a single 15 mg oral psilocybin dose; psychological effects occur with a blood plasma concentration of 4–6 µg/liter. Psilocybin is about 100 times less potent than LSD on a weight per weight basis, and the physiological effects last about half as long.
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Within 24 hours from administration 65% of the alucinogen is escreted by urine, while another 15-20% is excreted by bile and feces.
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Monoamine oxidase inhibitors (MAOI) have been known to prolong and enhance the effects of psilocybin. Alcohol consumption may enhance the effects of psilocybin, because acetaldehyde, one of the primary breakdown metabolites of consumed alcohol, reacts with biogenic amines present in the body to produce MAOIs related to tetrahydroisoquinoline and β-carboline. Tobacco smokers can also experience more powerful effects with psilocybin, because tobacco smoke exposure decreases levels of MAO in the brain and peripheral organs.
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This could lead to a lower usage o f glucose, but the same study admitted an increase glucose usage by the whole brain cell, meaning a differente use of this sugar while the drug is having effects.
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use of MRI (functional magnetic resounance) showed that the decresed blood flow associate with decreasing in neural activity. A simple explanation for this unexpected situation could be the serotoning agonist action of psilocybin, action that seems to be focused more on 5-HT receptors than on 5-HT2A.
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psilocibyn is able to act as a 5-HT agonist binding directly its receptors.
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augmented glucose consumption in several brain regions; this lead to the conclusion that psilocybin is some way able to modify the physiological glucosal metabolic rate of our body
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The strong inibition of the PCC is now thought to be most significant action of psilocybin on neural disaccoppiation
- Kenuvis Romero on 23 Jun 13
  
  Lower brain glucose metabolism is linked with increased capacity for working memory.
  
  <div class="cArrow"> </div><div class="cContentInner">Lower brain glucose metabolism is linked with increased capacity for working memory.</div>
  
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Psilocybin comprises approximately 1% of the weight of Psilocybe cubensis mushrooms, and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms, or 17 kilograms (37 lb) of fresh mushrooms, would be required for a 60-kilogram (130 lb) person to reach the 280 mg/kg LD50 value.
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psilocybin can cause anxiety and increased heart rate and BP which is very counter- productive for someone on metoprolol and micardis.
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propose the possibility to use psilocybin as a palliative therapy for terminal illness like cancer but also as a real antidepressive active principle available for the family of the patient. The rational is foundable in the fact that we usually administer SSRI as antidepressive agents, so psilocibyn sholud be useful in this purpose for its selective agonist action on 5-HT2A receptors
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iLearn Technology » Education Diigo - 2 views

ilearntechnology.com/?p=638 Diigo education review

shared by Maggie Tsai on 17 Nov 08 - Cached

What it is:  Education Diigo offers k-12 and higher ed educators premium Diigo accounts!  The premium accounts provide the ability to create student accounts for whole classes, students of the same class are automatically set up as a Diigo group so they can easily share bookmarks, annotations, and group forums, privacy settings so that only classmates and teachers can communicate with students, and any advertisments on Education Diigo are education related.  If you aren’t familiar with Diigo, it is a social bookmarking website where students can collaborate on the web.  Diigo works in to a project based learning environment nicely and allows for exploratory learning and collaboration.  
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Education Diigo is an outstanding place for students to solve problems together.  Provide students with a problem and send them on a web scavenger hunt to find the answer, students can post their findings and notes about their findings on Diigo.  Students can collaborate online to solve the problem.  Education Diigo is also a great place for “teachers to highlight critical information within text and images and write comments directly on the web pages, to collect and organize series of web pages and web sites into coherent and thematic sets, and to facilitate online conversations within the context of the materials themselves.”  This feature makes Education Diigo a great place to create webquest type lessons and virtual field trips around the web.    Diigo also allows teachers to collaborate and share resources among themselve. Education Diigo is a must for students who are learning to complete web-based research!
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Imagining College Without Grades :: Inside Higher Ed :: Higher Education's Source for N... - 1 views

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Last Week Tonight with John Oliver: Standardized Testing (HBO) - 44 views

www.youtube.com/watch news testing standardized testing

shared by Yozo Horiuchi on 05 May 15 - No Cached

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Why Online Programs Fail, and 5 Things We Can Do About It - Hybrid Pedagogy - 76 views

www.hybridpedagogy.com/...nd-5-things-we-can-do-about-it

shared by Ryan Ingersoll on 31 Jul 14 - No Cached

More and different types of learning and teaching are available in the digital environment. We must convince ourselves that we don’t yet understand digital education so we may open the doors more broadly to innovation and creativity
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we shouldn’t set off on a cruise, and build the ship as we go
- Rafael Morales_Gamboa on 31 Jul 14
  
  Why not? I might not be possible in the physical world, but that does not mean it cannot be done in the digital one.
  
  <div class="cArrow"> </div><div class="cContentInner">Why not? I might not be possible in the physical world, but that does not mean it cannot be done in the digital one.</div>
  
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Few institutions pay much attention to re-creating these spaces online
- Rafael Morales_Gamboa on 31 Jul 14
  
  They do not need to. The digital learning space does not have to be like the physical one.
  
  <div class="cArrow"> </div><div class="cContentInner">They do not need to. The digital learning space does not have to be like the physical one.</div>
  
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What spaces can we build online that aren’t quantified, tracked, scored, graded, assessed, and accredited?
- Rafael Morales_Gamboa on 31 Jul 14
  
  Are social networking applications you are talking about?
  
  <div class="cArrow"> </div><div class="cContentInner">Are social networking applications you are talking about?</div>
  
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What we have is a series of online classes with no real infrastructure to support the work that students do on college campuses outside and between those classes
- Rafael Morales_Gamboa on 31 Jul 14
  
  In physical schools that work have to be done on campus, because when students leave they become distant from each other. But that does not happen online: students are close together both inside and outside the "campus"; actually, they are simultaneously inside and outside campus.
  
  <div class="cArrow"> </div><div class="cContentInner">In physical schools that work have to be done on campus, because when students leave they become distant from each other. But that does not happen online: students are close together both inside and outside the "campus"; actually, they are simultaneously inside and outside campus.</div>
  
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Up to now, online learning has taken little notice of the web upon which it’s suspended
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Today, the road to access doesn’t necessarily detour through the university, and anyone, of just about any age, can travel it.
- Rafael Morales_Gamboa on 31 Jul 14
  
  This is, of course, an overstatement, as not everyone is prepared, given their development and living conditions, to take advantage of Internet.
  
  <div class="cArrow"> </div><div class="cContentInner">This is, of course, an overstatement, as not everyone is prepared, given their development and living conditions, to take advantage of Internet.</div>
  
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We’ve created happy little caskets inside which learning fits too neatly and tidily (like forums, learning management systems, and web conferencing platforms). We’ve timed learning down to the second, developed draconian quality assurance measures, built analytics to track every bit of minutiae, and we’ve championed the stalest, most banal forms of interaction — interaction buried beneath rubrics and quantitative assessment — interaction that looks the same every time in every course with every new set of students.
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Rafael Morales_Gamboa on 31 Jul 14

A critical view about e-learning as it mostly happens today.

<div class="cArrow"> </div><div class="cContentInner">A critical view about e-learning as it mostly happens today.</div>

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Ryan Ingersoll on 22 Jul 15

A critical view about e-learning as it mostly happens today.

<div class="cArrow"> </div><div class="cContentInner">A critical view about e-learning as it mostly happens today.</div>

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EDT-5-21173-S15: Two Useful Web 2.0 Tools - 36 views

eperalta.org/...discuss.php

shared by bettyj01 on 14 May 15 - No Cached

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Three questions to ask before choosing technology for education | Global Education &amp... - 56 views

educationandskillsforum.org/tions-technology-for-education education and technology education technology integration education technology choices

shared by H DeWaard on 04 Mar 15 - No Cached

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POLITIQUE : WIKILEAKS - Les secrets du chevalier blanc, actualité Tech & Net ... - 6 views

www.lepoint.fr/...lanc-28-07-2010-1219707_47.php politique wikileaks Assange

shared by Jac Londe on 05 Aug 10 - Cached

- Jac Londe on 05 Aug 10
  
  Cet homme vous veut du bien, il permet de chasser les hypocrites, les criminels et les menteurs du pouvoir. Wikileaks, c'est Millenium sur le Web.
  
  <div class="cArrow"> </div><div class="cContentInner">Cet homme vous veut du bien, il permet de chasser les hypocrites, les criminels et les menteurs du pouvoir. Wikileaks, c'est Millenium sur le Web.</div>
  
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WIKILEAKS
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Lancé en janvier 2007
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WikiLeaks fascine la presse, qui voit en lui une partie de son avenir.
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Une équipe mystérieuse
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Menacé par les services secrets américains et par tous les acteurs qu'il bouscule, WikiLeaks se protège. Pas de bureau ou d'adresse physique : seule une boîte postale à l'université de Melbourne, ainsi que des adresses e-mail anonymisées permettent aux informateurs de contacter l'équipe.
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L'infrastructure technique, parfois en peine par manque de financement, est basée en Suède, chez un hébergeur lié au très controversé The Pirate Bay. D'autres serveurs sont répartis dans le monde entier,
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le budget annuel de 600.000 dollars n'en est pas pour autant bouclé.
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Le porte-parole, Julian Assange, a toutefois mis en place un comité éditorial restreint, dont neuf noms sont dévoilés. Parmi eux, Wang Dan, l'un des 21 étudiants "les plus recherchés" par la Chine après les manifestations de Tiananmen en 1989, le Britannique Ben Laurie, génie mondialement reconnu de la cryptographie, ou encore le Brésilien Chico Whitaker, cofondateur du Forum social mondial.
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WikiLeaks a travaillé avec des élus islandais sur l'Icelandic Modern Media Initiative (IMMI)
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Son objectif dans la vie ? "Provoquer ou orienter des réformes politiques", en révélant des informations jusque-là cachées aux citoyens. Un peu comme ce qu'avait fait son modèle, Daniel Ellsberg, en 1971 : cet ancien analyste de la RAND Corporation (un très influent think tank américain) avait alors transmis à la presse les "Pentagon papers"
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