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Physiological Reviews - Department of Physiology, University of Wisconsin School of Medicine - Ischemic Cell Death in Brain Neurons - defining Cell Death - Major Features of Ischemic Cell Death - Ischemic Cell Death and Hypoxia

PubMed Abstract of review article on the role of calcium in ischemic cell death. Review concluded that calcium is one of the triggers involved in ischemic cell death, whatever the mechanism.

The Fern Lab - The Fern lab is located in the Department of Neurology at the University of Washington in Seattle. The lab's research focuses on ischemic injury of the brain, in particular the neonatal/developing brain. Ischemia is the term given to a loss of blood supply and can arise due to obstruction of a blood vessel (leading to a stroke), or from factors that are currently not well understood but which produce the brain injury that underlies cerebral palsy.

PubMed Central Abstract of study examining the Association of Cerebral Palsy with Other Disability in Children with Perinatal Arterial Ischemic Stroke

emedicine Hypoxic-Ischemic Encephalopathy Overview

Study is to determine whether nerve growth factor (cerebrolysin®) therapy will improve the psychomotor outcome in infants with moderate and severe hypoxic ischemic encephalopathy.

Journal of Child Neurology - Amplitude-Integrated EEG is useful in predicition of Neurodevelopmental Outsome in Full-Term Infants with Hypoxic-Ischemic Encephalopathy: A Meta-Analysis

2007 Icelandic study to assess the incidence, obstetric risk factors and the squela of severe asphyxia at Landspitali university hospital.

Study to determine if Antenatal Allopurinol Administration Reduce Post-Hypoxic-Ischemic Reperfusion Damage During Fetal Hypoxia in the Newborn

Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological out come of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to investigate the long-term functional and protective actions of granulocyte-colony stimulating factor (G-CSF) treatment in an experimental model of cerebral. RESULTS: Granulocyte-colony stimulation promoted somatic growth and prevented brain atrophy and underdevelopment of the heart in infant rats.

Clinical trial being sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD to evaluate whether induced whole-body hypothermia initiated between 6-24 hours of age and continued for 96 hours in infants ≥ 36 weeks gestational age with hypoxic-ischemic encephalopathy will reduce the incidence of death or disability at 18-24 months of age.

Completed Zhengzhou University study to investigate whether systemic hypothermia induced up to 10 hrs after birth would improve the neurodevelopmental outcome at 18 months in infants with moderate or severe HIE.

Hundreds of babies in the world are being treated with brain cooling to prevent brain injury after they lose oxygen at birth. This study will use the newly developed information from the magnet resonance image to determine the actual temperature of the brain. This will enable researchers to determine if the brain is being uniformly cooled and if techniques that provide cooling need to be changed to improve the injury prevention from cooling

Neuropathology online - Course material - Asphyxia and hypoxic-ischemic encephalopathy in mature infants

Objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy.

Current ongoing study being conducted to determine whether the plasticity of autologous intrathecal hematopoietic cells would improve the neurologic evolution of the pediatric patients with hypoxic ischemic brain injury.

Completed research study of head cooling to determine whether cooling babies' heads can reduce or prevent brain damage that may have resulted from temporarily reduced oxygen supply to the brain

NIH PUbMed Abstract of Russian study documenting the Physical and neurological state of the newborn afer perinatal asphyxia.This paper is presented as modern conceptions about asphyxia origin, risk factors, neurological and systemic complications for child nervous system and organism.

A recent study using high-dose rhEpo (3000 U rhEpo/kg body weight at birth) for neuroprotection in very preterm infants revealed that no signs of adverse effects of early high-dose rhEpo treatment in very preterm infants were identified. Contrary to this, a recent study in PVL of a rat model revealed that using a low dose rhEpo (50-100 U/kg) was effective in the treatment of brain damage induced by hypoxia-ischemia and did not affect normal oligodendrocyte maturity. On this basis, the researchers intent to investigate (1) whether low-dose rhEpo (100 U/kg) or high-dose rhEpo (3,000 U/kg) given to very preterm infants (gestation age < 32 weeks) immediately after birth and subsequently during the first 2 days is safe and possesses neuroprotective properties;(2) whether there are gender differences in response to the hypoxia-ischemic insult and EPO treatment; (3)the pharmacokinetics of low dose and high dose rhEPO.

Trakya University School of Medicine, Turkey study to evaluate the impact of the Neonatal Resuscitation Program (NRP) on morbidity and mortality of newborn infants with perinatal asphyxia. The study concluded that after Neonatal resuscitation (RP) courses, the number of patients with perinatal asphyxia and with no resuscitation and also the duration of hospitalization decreased significantly, whereas the first minute Apgar scores increased significantly.