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NIH PubMed Central Archives of Disease in Childhood - Umbilical venous blood ph: a useful aid in the diagnosis of asphyxia at birth. Umbilical venous blood, and umbilical arterial blood pH, PO2, PCO2, and base excess were determined in 453 term infants at birth. The results indicate that umbilical venous blood pH, and umbilical arterial blood pH are significantly related to each another.

Clinical Chemistry - 1997 NACB Symposium - Evaluation of the newborn's blood gas status - This paper discusses considerations for interpretation of blood gases in the newborn period. Blood gas measurements and noninvasive estimations provide important information about oxygenation. Its determined that Blood gas measurements and complementary, noninvasive monitoring techniques provide the clinician with information essential to patient assessment, therapeutic decision making, and prognostication. Blood gas measurements are as important for ill newborn infants as for other critically ill patients, but unique challenges are provided by rapidly changing physiology, difficult access to arterial and mixed venous sampling sites, and small blood volumes.

Description and meaning of Blood Gases and related tests.

obgyn.net - Article - Cord blood gases to determine umbilical artery acid-base analysis - Charts and values available on this site outlining Normal fetal cord blood pH and gas values and abnormal fetal cord pH and gas values.

Explanation of Blood Work values and meanings. AEGiS is made possible through unrestricted grants from Roxane Laboratories, the National Library of Medicine. This article first appeared in 1994

Information on ongoing study being sponsored by Medical College of Georgia to test the safety and effectiveness of cord blood infusion in children with motor disabilities due to cerebral palsy.

The Fern Lab - The Fern lab is located in the Department of Neurology at the University of Washington in Seattle. The lab's research focuses on ischemic injury of the brain, in particular the neonatal/developing brain. Ischemia is the term given to a loss of blood supply and can arise due to obstruction of a blood vessel (leading to a stroke), or from factors that are currently not well understood but which produce the brain injury that underlies cerebral palsy.

Information on completed study assessing Regulation of Cerebral Blood flow in Very Low Birth Weight infants

The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives. NHLBI stimulates basic discoveries about the causes of disease, enables the translation of basic discoveries into clinical practice, fosters training and mentoring of emerging scientists and physicians, and communicates research advances to the public. Creates and supports a robust, collaborative research infrastructure in partnership with private and public organizations, including academic institutions, industry, and other government agencies

National Heart Lung and Blood Institute (NHLBI) Diseases and Conditions Index (DCI). This Web-based health index gives you a quick and easy way to get complete and dependable information about heart, lung, and blood diseases and sleep disorders.

Study to create a bio-repository of blood samples from patients and healthy subjects who are participating in NINDS motor learning studies. A variety of genes that may affect motor learning are being increasingly identified, and variations among these genes, referred to as polymorphisms, may help explain individual differences.

Study being sponsored by the Medical College of Georgia to test the safety and effectiveness of a cord blood infusion in children who have motor disability due to cerebral palsy (CP).

Medical College of Georgia researchers are conducting a clinical trial to determine whether an infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy.

Study is to evaluate the pharmacokinetics (blood levels), pharmacodynamics (how the drug acts on the body), and the safety of rabeprazole sodium for the treatment of gastroesophageal reflux disease (GERD) in new borns and pre-term infants (less than 44 weeks of age).

Pancreatitis is caused by an acute injury on the pancreas. We have recently reported a high rate of acute pancreatitis developing in children who undergo posterior spinal fusion for scoliosis (to correct spinal curve). We showed that the amount of blood loss during the surgery is related to the incidence of pancreatitis

Study will measure the frequency of several coagulation factor abnormalities (factor V Leiden, prothrombin 20210A, protein C, protein S, antithrombin III, and antiphospholipid antibodies) in children with a history of porencephaly and stroke, and will compare these to the prevalence of these mutations in population controls and family members.

Preterm infants are born with immature lungs and often require help with breathing shortly after birth. This currently involves administering 100% oxygen. Unfortunately, delivery of high oxygen concentrations leads to the production of free radicals that can injure many organ systems. Term and near-term newborns deprived of oxygen during or prior to birth respond as well or better to resuscitation with room air (21% oxygen) compared to 100% oxygen. However, a static concentration of 21% oxygen may be inappropriate for preterm infants with lung disease. Our study will investigate how adjusting the amount of oxygen given to sick preterm newborns will affect the ability to maintain a safe oxygen level in their blood

NHLBI ARDS Clinical Network web site. This site was established to provide information to the public on ARDS and the ARDS Network. In order to hasten the development of effective therapy for Acute Respiratory Distress Syndrome (ARDS), the National Heart, Lung, and Blood Institute, National Institutes of Heath, initiated a clinical network to carry out multi center clinical trials of ARDS treatments. The goal of the Network is to efficiently test promising agents, devices, or management strategies to improve the care of patients with ARDS.

Canadian study to examine the roles of clinical risk scoring, electronic fetal heart monitoring and fetal blood gas and acid-base assessement in the prediction of intrapartum fetal asphyxia in term pregnancies. The study concluded that although fetal heart rate patterns will not discriminate all asphyxial exposures, continuous fetal heart rate monitoring supplemented by fetal blood gas and acid-base assessment can be a useful fetal assessment paradigm for intrapartum fetal asphyxia

PubMed Abstract - Early diagnosis of perinatal asphyxia by nucleated red blood cell count: a case-control study