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Matti Narkia

NephroPal: PPARs - 0 views

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    "Summer vs Winter Mode: Explaining AMPK
    Last year I read an article which made a statement that has not left my mind. The statement went as follows: "You are only good as your mitochondria." In fact, the more a dwell into the details of human metabolism, the more I sense that this is true - especially with the metabolic syndrome.

    For those who are not familiar with the concept of mitochondria, they are the tiny energy factories within the cells that produce cellular energy through aerobic means (meaning oxygen). Mitochondria utilize oxygen to ultimately produce Adenosine Triphosphate or simply ATP. ATP relays energy by donating a phosphate bond resulting in Adenosine Diphosphate (ADP). Another phosphate release would entail Adenosine Monophosphate or AMP. ATP is one of the main sources of cellular energy in the body
Matti Narkia

Cooling Inflammation: Inflammation and Vitamin D Deficiency - 0 views

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    "Let's shine some sunlight on these knowledge deficiencies:

    * Serum vitamin D levels have been dropping (as chronic inflammation has been increasing) over the last three decades -- has something changed in our diets?
    * Vitamin D deficiencies occur globally (not restricted to Northern latitudes or winter) -- related to diet?
    * Women are more vulnerable, because of cultural modesty in some countries, but males are still D-deficient.
    * A subset of people exposed to ample sunshine are still D-deficient.
    * Vitamin D deficient individuals also have elevated TNF.
    * Vitamin D deficiency and inflammation are risk factors in the same diseases.

    It seems that the simplest conclusion is that chronic inflammation leads to vitamin D deficiency, even though vitamin D deficiency may also contribute to inflammation."
Matti Narkia

VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP) - 0 views

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    VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP)
    Van den Berghe and colleagues at the University of Leuven in Belgium appear to be the first to show that simple, natural and cheap vitamin D (cholecalciferol) lowers CRP in critically ill patients. Even small amounts of cholecalciferol (500 IU) lowered CRP by more than 25% in a small group of critically ill patients. Another marker of inflammation (IL-6) was reduced even more. The researchers also found that critically ill patients were profoundly deficient in vitamin D.
Matti Narkia

Higher serum vitamin D concentrations are associated with longer leukocyte telomere len... - 0 views

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    Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
    Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A.
    Am J Clin Nutr. 2007 Nov;86(5):1420-5.
    PMID: 17991655
Matti Narkia

Putting cardiovascular disease and vitamin D insufficiency into perspective - 0 views

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    Vitamin D and disease prevention with special reference to cardiovascular disease.
    Zittermann A.
    Prog Biophys Mol Biol. 2006 Sep;92(1):39-48. Epub 2006 Feb 28. Review.
    PMID: 1660034

Matti Narkia

The Heart Scan Blog: Vitamin D and inflammation - 0 views

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    A German group has now shown that the important inflammatory marker, tumor necrosis factor (TNF), is also reduced by vitamin D supplementation. Many studies have implicated increased TNF levels in promoting cancer.

    In this study, a modest vitamin D dose of 3320 units (83 micrograms) was given vs. placebo. The 25-hydroxy D level reached in the treated group was 34.2 ng/ml (85.5 nmol/L), which resulted in a 26.5% reduction in TNF compared with 18.7% reduction (?) in the placebo group.
Matti Narkia

Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascu... - 0 views

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    Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
    Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer R.
    Am J Clin Nutr. 2009 May;89(5):1321-7. Epub 2009 Mar 25.
    PMID: 19321573
Matti Narkia

Relationship Between Vitamin D Deficiency And Increased Inflammation In Healthy Women - 0 views

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    According to a recent study in the Archives of Internal Medicine, 75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri nutritional sciences researcher has found that vitamin D deficiency is associated with inflammation, a negative response of the immune system, in healthy women.
Matti Narkia

Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 2... - 0 views

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    Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women.
    Peterson CA, Heffernan ME.
    J Inflamm (Lond). 2008 Jul 24;5:10.
    PMID: 18652680
    doi:10.1186/1476-9255-5-10

    Conclusion
    Serum 25(OH)D status is inversely related to TNF-α concentrations in healthy women, which may in part explain this vitamin's role in the prevention and treatment of inflammatory diseases. Results gleaned from this investigation also support the need to re-examine the biological basis for determining optimal vitamin D status.
Matti Narkia

Vitamin D Deficiency Related To Increased Inflammation In Healthy Women - 0 views

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    ScienceDaily (Apr. 8, 2009) - According to a recent study in the Archives of Internal Medicine, 75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri nutritional sciences researcher has found that vitamin D deficiency is associated with inflammation, a negative response of the immune system, in healthy women.
Matti Narkia

Vitamin D supplementation improves cytokine profiles in patients with congestive heart ... - 0 views

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    Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.Am J Clin Nutr. 2006 Apr;
Matti Narkia

Vitamin D and autoimmunity: new aetiological and therapeutic considerations -- Arnson e... - 0 views

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    itamin D and autoimmunity: new aetiological and therapeutic considerations.
    Arnson Y, Amital H, Shoenfeld Y.
    Ann Rheum Dis. 2007 Sep;66(9):1137-42. Epub 2007 Jun 8. Review.
    PMID: 17557889
    doi:10.1136/ard.2007.069831
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