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Matti Narkia

Vitamin D deficiency is associated with worse cognitive performance and lower bone dens... - 0 views

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    Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
    Wilkins CH, Birge SJ, Sheline YI, Morris JC.
    J Natl Med Assoc. 2009 Apr;101(4):349-54.
    PMID: 19397226

    CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Matti Narkia

Relation of body fat indexes to vitamin D status and deficiency among obese adolescents... - 0 views

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    Relation of body fat indexes to vitamin D status and deficiency among obese adolescents.
    Lenders CM, Feldman HA, Von Scheven E, Merewood A, Sweeney C, Wilson DM, Lee PD, Abrams SH, Gitelman SE, Wertz MS, Klish WJ, Taylor GA, Chen TC, Holick MF; Elizabeth Glaser Pediatric Research Network Obesity Study Group.
    Am J Clin Nutr. 2009 Sep;90(3):459-67. Epub 2009 Jul 29.
    PMID: 19640956

    RESULTS: The mean (+/-SD) age of the adolescents was 14.9 +/- 1.4 y; 38 (66%) were female, and 8 (14%) were black. The mean (+/-SD) body mass index (in kg/m(2)) was 36 +/- 5, FM was 40.0 +/- 5.5%, and VAT was 12.4 +/- 4.3%. Seventeen of the adolescents were vitamin D deficient, but none had elevated PTH concentrations. Bone mineral content and bone mineral density were within 2 SDs of national standards. In a multivariate analysis, 25(OH)D decreased by 0.46 +/- 0.22 ng/mL per 1% increment in FM (beta +/- SE, P = 0.05), whereas PTH decreased by 0.78 +/- 0.29 pg/mL per 1% increment in VAT (P = 0.01). CONCLUSIONS: To the best of our knowledge, our results show for the first time that obese adolescents with 25(OH)D deficiency, but without elevated PTH concentrations, have a bone mass within the range of national standards (+/-2 SD). The findings provide initial evidence that the distribution of fat may be associated with vitamin D status, but this relation may be dependent on metabolic factors
Matti Narkia

Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset... - 0 views

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    Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
    Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, Chen S, Zehnder D, Lin YC, Yang H, Hewison M, Adams JS.
    Gut. 2004 Aug;53(8):1129-36.
    PMID: 15247180
    doi: 10.1136/gut.2003.036657.

    Conclusions: These data demonstrate that elevated 1,25(OH)2D is more common in CD than previously appreciated and is independently associated with low bone mineral density. The source of the active vitamin D may be the inflamed intestine. Treatment of the underlying inflammation may improve metabolic bone disease in this subgroup of patients.
Matti Narkia

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone... - 0 views

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    Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
    Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
    Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
    PMID: 12936933

    CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
Matti Narkia

Vitamin D status affects serum parathyroid hormone concentrations during winter in fema... - 0 views

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    Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
    Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
    Am J Clin Nutr. 2001 Aug;74(2):206-10.
    PMID: 11470722

    Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
Matti Narkia

A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in... - 0 views

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    A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in early and mid-puberty girls - a cross-sectional study.
    Viljakainen HT, Palssa A, Kärkkäinen M, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    Br J Nutr. 2006 Jul;96(1):124-30.
    PMID: 16870000

    Seasonal variation in S-25-OHD and bone remodelling markers accompanied by negative correlation between S-25-OHD and S-iPTH was seen in this cross-sectional study of adolescent girls. In addition, the seasonal rhythm contributed 7.0-7.6 % difference in the BMD of lumbar vertebrae and left femur in early puberty girls. This variation should be avoided since it could hamper peak bone mass attainment.
Matti Narkia

A positive dose-response effect of vitamin D supplementation on site-specific bone mine... - 0 views

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    A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention.
    Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    J Bone Miner Res. 2006 Jun;21(6):836-44.
    PMID: 16753014
    doi: 10.1359/jbmr.060302

    We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.
Matti Narkia

25-Hydroxyvitamin D and functional outcomes in adolescents -- Lamberg-Allardt and Vilja... - 0 views

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    25-Hydroxyvitamin D and functional outcomes in adolescents.
    Lamberg-Allardt CJ, Viljakainen HT.
    Am J Clin Nutr. 2008 Aug;88(2):534S-536S. Review.
    PMID: 18689396

    CONCLUSIONS

    Cross-sectional studies have shown a relation among serum 25(OH)D concentration, serum PTH concentration, and BMD in adolescents. Long-term randomized controlled intervention studies have shown that vitamin D3 supplementation has a positive effect on BMD in adolescence; some of these studies found an effect with doses as small as 5 µg (200 IU) to 10 µg (400 IU) per day, or without supplemental calcium.
Matti Narkia

Wintertime vitamin D supplementation inhibits seasonal variation of calcitropic hormone... - 0 views

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    Wintertime vitamin D supplementation inhibits seasonal variation of calcitropic hormones and maintains bone turnover in healthy men.
    Viljakainen HT, Väisänen M, Kemi V, Rikkonen T, Kröger H, Laitinen EK, Rita H, Lamberg-Allardt C.
    J Bone Miner Res. 2009 Feb;24(2):346-52.
    PMID: 18847321
Matti Narkia

[Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease ... - 0 views

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    [Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and its correlation with bone mineral density]
    Souza HN, Lora FL, Kulak CA, Mañas NC, Amarante HM, Borba VZ.
    Arq Bras Endocrinol Metabol. 2008 Jun;52(4):684-91. Portuguese.
    PMID: 18604382
Matti Narkia

Circulating 25-Hydroxyvitamin D Levels Indicative of Vitamin D Sufficiency: Implication... - 0 views

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    Using these functional indicators, several studies have more accurately defined vitamin D deficiency as circulating levels of 25(OH)D ≤ 80 nmol or 32 µg/L. Recent studies reveal that current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.

    Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D.
    Hollis BW.
    J Nutr. 2005 Feb;135(2):317-22. Review.
    PMID: 15671234 [
Matti Narkia

Long-term effects of giving nursing home residents bread fortified with 125 {micro}g (5... - 0 views

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    Long-term effects of giving nursing home residents bread fortified with 125 {micro}g (5000 IU) vitamin D3 per daily serving.
    Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, Vieth R.
    Am J Clin Nutr. 2009 Feb 25. [Epub ahead of print]
    PMID: 19244376
Matti Narkia

Long-term effects of giving nursing home residents bread fortified with 125 microg (500... - 0 views

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    Long-term effects of giving nursing home residents bread fortified with 125 microg (5000 IU) vitamin D(3) per daily serving.
    Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, Vieth R.
    Am J Clin Nutr. 2009 Apr;89(4):1132-7. Epub 2009 Feb 25.
    PMID: 19244376
    doi:10.3945/ajcn.2008.26890
Matti Narkia

A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitam... - 0 views

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    Matsumoto T, Miki T, Hagino H, Sugimoto T, Okamoto S, Hirota T, Tanigawara Y, Hayashi Y, Fukunaga M, Shiraki M, Nakamura T.
    A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-
Matti Narkia

Vitamin D status and its relationship to body fat, final height, and peak bone mass in ... - 0 views

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    Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women.\nKremer R, Campbell PP, Reinhardt T, Gilsanz V.\nJ Clin Endocrinol Metab. 2009 Jan;94(1):67-73. Epub 2008 Nov 4.\nPMID: 18984659
Matti Narkia

The Heart Scan Blog: "High-dose" Vitamin D - 0 views

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    I stumbled on one of the growing number of local media stories on the power of vitamin D. \nIn one story, a purported "expert" was talking about the benefits of "high-dose" vitamin D, meaning up to 1000, even 2000 units per day. \nI regard this as high-dose---for an infant. \nJudging by my experiences, now numbering well over 1000 patients over three years time, I'd regard this dose range not as "high dose," nor moderate dose, perhaps not even low dose. I'd regard it as barely adequate.
Matti Narkia

Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health o... - 0 views

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    Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B.
    Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.
    Am J Clin Nutr. 2006 Jul;84(1):18-28. Review.
    PMID: 16825677
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