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Matti Narkia

Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease.... - 0 views

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    Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease. Waterhouse JC, Perez TH, Albert PJ. Ann N Y Acad Sci. 2009 Sep;1173:757-65. PMID: 19758226
Matti Narkia

Defensin - Wikipedia, the free encyclopedia - 0 views

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    "Defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates. They are active against bacteria, fungi and many enveloped and nonenveloped viruses. They consist of 18-45 amino acids including six (in vertebrates) to 8 conserved cysteine residues. Cells of the immune system contain these peptides to assist in killing phagocytized bacteria, for example in neutrophil granulocytes and almost all epithelial cells. Most defensins function by binding to microbial cell membrane, and once embedded, forming pore-like membrane defects that allow efflux of essential ions and nutrients
Matti Narkia

Harvard Gazette: Vitamin D critical to human TB response - 0 views

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    Vitamin D plays a critical role in the human body's response to tuberculosis, according to new research that explains why people of African descent are more susceptible to TB. The research also suggests a new way to fight one of the world's deadliest diseases: with a simple dietary supplement. Tuberculosis, usually caused when a person inhales tuberculosis bacteria, killed an estimated 1.7 million people in 2003 and is the leading cause of death for people afflicted with AIDS, according to the World Health Organization (WHO).
Matti Narkia

Cathelicidin - Wikipedia, the free encyclopedia - 0 views

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    "Cathelicidin antimicrobial peptide is a family of polypeptides found in lysosomes in polymorphonuclear leukocytes (PMNs).[1] Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain. Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins were originally found in neutrophils but have since been found in many other cells including epithelial cells and macrophages activated by bacteria, viruses, fungi, or the hormone 1,25-D"
Matti Narkia

Vitamin D and influenza - Wikipedia, the free encyclopedia - 0 views

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    "Numerous studies link Vitamin D and influenza, as well as Vitamin D and respiratory infections more generally. This vitamin up-regulates genetic expression of various endogenous antimicrobial peptides (AMP), which exhibit broad-spectrum microbicidal activity against bacteria, fungi, and viruses. Reports discussed below indicate that susceptibility to influenza is reduced with higher levels of sun exposure or vitamin D supplementation. Seasonal variation of vitamin D levels in humans can help explain the seasonality of flu epidemics."
Matti Narkia

Olmesartan - Wikipedia, the free encyclopedia - 0 views

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    "Olmesartan (trade names Benicar, Olmetec) is an angiotensin II receptor antagonist used to treat high blood pressure. The prodrug olmesartan medoxomil is marketed worldwide by Daiichi Sankyo, Ltd. and in the United States by Daiichi Sankyo, Inc. and in India by Ranbaxy Laboratories Ltd. under the trade name Olvance. Olmesartan may possess high affinity for the Vitamin D Receptor, based on molecular modeling studies[2], but these results have not been duplicated in clinical trials. Because of the role of the Vitamin D receptor in innate immunity[3], this would indicate that olmesartan has immune modulatory properties. This theory is currently the premise underlying the Marshall Protocol, which uses olmesartan to impose a chemical blockade on 1,25 Vitamin D as part of a treatment of sarcoidosis and other diseases. The Marshall Protocol asserts that, assuming the etiology of these diseases is based on infection by cell-wall-deficient bacteria, restoring proper Vitamin D ratios via olmesartan dosing, combined with pulsed antibiotic dosing, would result in a cure.!
Matti Narkia

Vitamin D: the alternative hypothesis. - Autoimmun Rev. 2009 Jul;8(8):639-44. (full tex... - 0 views

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    Vitamin D: the alternative hypothesis. Albert PJ, Proal AD, Marshall TG. Autoimmun Rev. 2009 Jul;8(8):639-44. Epub 2009 Feb 12. Review. PMID: 19393200 Emerging molecular evidence suggests that symptomatic improvements among those administered vitamin D is the result of 25-D's ability to temper bacterial-induced inflammation by slowing VDR activity. While this results in short-term palliation, persistent pathogens that may influence disease progression, proliferate over the long-term.
Matti Narkia

Vitamin D: The alternative hypothesis. - ScienceDirect - Autoimmunity Reviews, 2009 - 0 views

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    Albert et al. Vitamin D: The alternative hypothesis. Autoimmunity Reviews, 2009 doi:10.1016/j.autrev.2009.02.011 
Matti Narkia

Low Levels Of Vitamin D In Patients With Autoimmune Disease May Be Result, Not Cause, O... - 0 views

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    ScienceDaily (Apr. 8, 2009) - Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate autoimmune disease.
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