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Matti Narkia

Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volum... - 0 views

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    Vitamin D, nervous system and aging.
    P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. .
    Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286
    NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION
    doi:10.1016/j.psyneuen.2009.07.003

    This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Matti Narkia

Vitamin D, aging, and cancer. Pentti Tuohimaa. 2008; Nutrition Reviews - Wiley InterSci... - 0 views

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    Vitamin D, aging, and cancer.
    Tuohimaa P.
    Nutr Rev. 2008 Oct;66(10 Suppl 2):S147-52. Review.
    PMID: 18844842
    DOI: 10.1111/j.1753-4887.2008.00095.x

    Deficiency of the prohormone calcidiol (25OH vitamin D3) seems to be associated with several aging-related chronic diseases including cancer. Our results suggest that calcidiol is mainly responsible for differentiation homeostasis, whereas calcitriol might be more involved in calcium homeostasis. Therefore, an imbalance of calcidiol rather than calcitriol is a risk factor for cancer and chronic diseases. Calcidiol insufficiency, as well as insufficient solar exposure, is associated with increased risk of several solid cancers. Both a vitamin D3 deficiency and a high concentration of calcidiol may increase cancer risk. Similarly, aging phenomena show a U-shaped association with vitamin D bioactivity. Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined.
Matti Narkia

Vitamin D and aging. [J Steroid Biochem Mol Biol. 2009] - PubMed result - 0 views

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    Vitamin D and aging.
    Tuohimaa P.
    J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):78-84. Review.
    PMID: 19444937
Matti Narkia

Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mort... - 0 views

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    Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
    Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
    Nutr Res. 2009 Aug;29(8):525-30.
    PMID: 19761886
    doi:10.1016/j.nutres.2009.07.007

    Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.
Matti Narkia

Vitamin D and aging. [J Steroid Biochem Mol Biol. 2009] - PubMed result - 0 views

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    Vitamin D and aging.
    Tuohimaa P.
    J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):78-84. Review.
    PMID: 19444937
Matti Narkia

Vitamin D and cognitive performance in adults: a systematic review. - Eur J Neurol. 200... - 0 views

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    Vitamin D and cognitive performance in adults: a systematic review.
    Annweiler C, Allali G, Allain P, Bridenbaugh S, Schott AM, Kressig RW, Beauchet O.
    Eur J Neurol. 2009 Oct;16(10):1083-9. Epub 2009 Jul 29.
    PMID: 19659751
    DOI: 10.1111/j.1468-1331.2009.02755.x

    This systematic review shows that the association between serum 25OHD concentrations and cognitive performance is not yet clearly established. The inconclusive results of the reviewed studies could be due to methodology, types of the cognitive tasks used and/or the cellular mechanisms of vitamin D.
Matti Narkia

Higher serum vitamin D concentrations are associated with longer leukocyte telomere len... - 0 views

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    Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
    Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A.
    Am J Clin Nutr. 2007 Nov;86(5):1420-5.
    PMID: 17991655
Matti Narkia

Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitam... - 0 views

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    Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.
    Harris SS, Dawson-Hughes B.
    J Am Coll Nutr. 2002 Aug;21(4):357-62.
    PMID: 12166534

    Conclusions: There appears to be no age-related impairment among men in the absorption or metabolism of 20 µg/day of vitamin D3 taken orally for at least eight weeks.
Matti Narkia

Vitamin D, nervous system and aging - ScienceDirect - Psychoneuroendocrinology - 0 views

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    Vitamin D, nervous system and aging.
    Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A.
    Psychoneuroendocrinology. 2009 Aug 4. [Epub ahead of print]
    PMID: 19660871
Matti Narkia

25(OH)D Serum Levels Decline With Age Earlier in Women Than in Men and Less Efficiently... - 0 views

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    25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.
    Maggio D, Cherubini A, Lauretani F, Russo RC, Bartali B, Pierandrei M, Ruggiero C, Macchiarulo MC, Giorgino R, Minisola S, Ferrucci L.
    J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1414-9.
    PMID: 16339327

    Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.
Matti Narkia

Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship ... - 0 views

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    Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.
    Vieth R, Ladak Y, Walfish PG.
    J Clin Endocrinol Metab. 2003 Jan;88(1):185-91.
    PMID: 12519850

    This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function
Matti Narkia

Aging decreases the capacity of human skin to produce vitamin D3. - Journal of Clinical... - 0 views

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    Aging decreases the capacity of human skin to produce vitamin D3.
    MacLaughlin J, Holick MF.
    J Clin Invest. 1985 Oct;76(4):1536-8.
    PMID: 2997282
    doi:10.1172/JCI112134

    An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
Matti Narkia

Optimal vitamin D status attenuates the age-associated increase in systolic blood press... - 0 views

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    Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey.
    Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V.
    Am J Clin Nutr. 2008 Jan;87(1):136-41.
    PMID: 18175747

    Conclusions: SBP is inversely associated with serum vitamin D concentrations in nonhypertensive white persons in the United States. This observation provides a rationale for studies on the potential effects of vitamin D supplementation as a method to reduce SBP in persons at risk of hypertension.
Matti Narkia

Aging decreases the capacity of human skin to produce vitamin D3. - J Clin Invest. 198... - 0 views

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    Aging decreases the capacity of human skin to produce vitamin D3.
    MacLaughlin J, Holick MF.
    J Clin Invest. 1985 Oct;76(4):1536-8.
    PMID: 2997282
Matti Narkia

Vitamin D Status Predicts Physical Performance and Its Decline in Older Persons -- Wich... - 0 views

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    Vitamin D status predicts physical performance and its decline in older persons.
    Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2058-65. Epub 2007 Mar 6.
    PMID: 17341569
    doi:10.1210/jc.2006-1525

    ONCLUSIONS: Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.
Matti Narkia

Vitamin D in the Spotlight; This critical nutrient builds bones, helps fight infection ... - 0 views

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    For many years, vitamin D was boring--even to doctors. Because it was considered good for bones and not much else, multitaskers like vitamin A, B vitamins and vitamin E hogged all the press. But recent studies have thrust this long-neglected nutrient into the spotlight. Scientists now think vitamin D may affect everything from diabetes to cancer. They're also finding that many people don't have enough of it.
Matti Narkia

Association between vitamin D status and physical performance: the InCHIANTI study. - J... - 0 views

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    Association between vitamin D status and physical performance: the InCHIANTI study.\nHouston DK, Cesari M, Ferrucci L, Cherubini A, Maggio D, Bartali B, Johnson MA, Schwartz GG, Kritchevsky SB.\nJ Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):440-6.\nPMID: 17452740
Matti Narkia

Environmental factors that influence the cutaneous production of vitamin D -- Holick 61... - 0 views

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    Environmental factors that influence the cutaneous production of vitamin D.
    Holick MF.
    Am J Clin Nutr. 1995 Mar;61(3 Suppl):638S-645S. Review.
    PMID: 7879731
Matti Narkia

Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-co... - 0 views

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    Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438).\nAvenell A, Cook JA, Maclennan GS, Macpherson GC.\nAge Ageing. 2007 Sep;36(5):574-7. Epub 2007 Aug 15. No abstract available.\nPMID: 17702768 \ndoi:10.1093/ageing/afm091
Matti Narkia

Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment. - J Geriatr Psychiatr... - 0 views

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    Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment.\nLlewellyn DJ, Langa K, Lang I.\nJ Geriatr Psychiatry Neurol. 2009 Feb 4. [Epub ahead of print]\nPMID: 19073839 \ndoi:10.1177/0891988708327888\n
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