Dr. Goodyear

endocrine abnormalities associated with inborn errors of metabolism.

Interesting abstract of a a patient that presents with hypoparathyroidism and hypogonadism concurrently.  Hereditary hemochromatosis was underlying.

good discussion of the nongenomic signaling that occurs from Estradiol, Estrone, and Estriol.

In obese men with low T and type 2 diabetes, Testosterone replacement improves insulin sensitivity.  Glycated hemoglobin was also improved.  In this study group, a decrease in visceral adiposity and TC was seen.

low SHBG found to be more associated with metabolic syndrome in older men than low Testosterone.  The study consisted of 2502 men older than 70.  The authors proposed this occurs through the relationship between SHBG and insulin sensitivity.  I think that is a little too simplistic.

Low SHBG associated with elevated insulin levels. This was found in both sexes.  Low SHBG associated with type II Diabetes, but Increased SHBG found to be associated with Type I Diabetes.

Low SHGB associated with increased association with metabolic syndrome components.  Low SHBG particuraliy associated with increased obesity (visceral) and glucose dysmetabolism. This study looked at premenopausal women.

The tide is beginning to shift on testosterone and Prostate Cancer.  A literature review finds no support for Testosterone and Prostate carcinogenesis or low Testosterone providing any protection against prostate cancer.  

a good read!

Association of low TT, SHBG, and free Testosterone with MetS was found in this study on men.  The association was influenced by BMI i.e. the overweight were found to have a higher association than the normal BMI.

Study of 2361 Chinese men found that men with MetS had lower TT, bioavailable Testosterone, free Testosterone and SHBG than those men without MetS.  Additionally, Total Testosterone and SHBG were both inversely associated with the risk of MetS.  This inverse association stood for both after adjusting for the other.

Men with low T and low SHBG have a significantly elevated risk of metabolic syndrome.  Other studies have actually shown that low SHBG is more associated and that TT is more than free Testosterone.

Salivary cortisol samples shown to be stable for long length of time.

Study deals with the storage temp of salivary hormone samples.

women with high E2 versus low E2 had better cognitive function.

full article on the previously posted abstract on Lp(a).  

Lp(a) is a useful biomarker in the overall assessment of those at moderate to high risk of CVD.

low SHBG in post-menopausal women correlates with increased risk of metabolic syndrome.  More than that, there is an inverse correlation with SHBG in women and metabolic syndrome components.  Also, Increasing components of MetS was correlated with Testosterone and free androgen index.

Interesting study finds hyperandrogenism stimulates excessive inflammatory response to glucose intake.  This study was done in otherwise healthy women not in women with PCOS.  The inflammatory cytokine production was via NF-KappaB activation.  Again, this has negative implications in women being doped with Testosterone.

Study points to inflammation causing hyperandrogenism via ovarian theca stimulation.

Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.