Dr. Goodyear

2 year old "best practice" guidelines for bladder cancer.

low DHEA and DHEAS is associated with increased risk of bladder cancer in both sexes.  

Androgen receptors may be associated with bladder cancer progression.  This study finds AR up regulates Epidermal growth factor in bladder cancer cells.

Study finds that loss of AR and ER-alpha is associated with high grade bladder cancer and ER-beta was positively associated. This has been contradicted by other studies.

multi-center study finds no association between androgen receptor expression and invasive bladder cancer.  There was also no difference between male and female in androgen receptor expression.

review article on risk/benefits of Testosterone therapy in men.

This study focused on coactivators in bladder cancer.  Although, the study found that AR expression was inversely associated with advancing bladder cancer stage--This is opposite from the positive correlation with Prostate Cancer.  

ER-beta is commonly expressed versus ER-alpha in bladder cancer.  There was a positive correlation between ER-beta expression and invasion and grade of cancer.  This study also found that blockade of the ER resulted in a decrease in growth.

Study finds that a decrease in androgen receptor inhibits bladder cancer cell growth in vivo and in vitro studies.  

Study finds that loss of Androgen receptors associated with advanced stage bladder cancer in men.

Another animal study finds Testosterone plays a role in bladder cancer development.  The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no.  The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.

Animal study finds that Androgen Receptors play role in bladder cancer development and progression in men.

PCBs, Lead, and Mercury associated with liver disease in American adults.  These possible causes need to be considered with non-explainable hepatitis.

Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy.  No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy.  No harm was found either.  Data was sparse.   Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3.  At this point not studies have pointed to reduced obesity in children.

Study of 3 cohorts with a median of 5 years of Testosterone therapy in men with low T, finds no increase risk in prostate cancer.

Just an abstract from the Presentation at the 2014 Scientific Session. The abstract points to a 40% reduction in CAD with the onset of BHRT (Estradiol and progesterone topical) within 6 years of menopause compared to women 10 years post-menopause.  This points to timing as a critical component of BHRT in women and CAD.

Case study of a 14 year old treated with hemp oil for ALL.

Pilot study of THC for advanced, recurrent glioblastoma multiforme.  The infused THC appeared to be safe and provide some anti proliferative activity, but all patients died within 1 year.

CBD downregulates Id-1 gene activity in vitro and in vivo in breast cancer cell cultures.

CBD reduces breast cancer proliferation, invasion, and metastasis.  Analysis was via human cell cultures.