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Nathan Goodyear

Best practice in the treatment of nonmuscle invasive bladder cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3263923

bladder cancer bladder cancer

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    2 year old "best practice" guidelines for bladder cancer.
Nathan Goodyear

http://cancerres.aacrjournals.org/content/51/5/1366.full.pdf - 0 views

cancerres.aacrjournals.org/...1366.full.pdf

bladder cancer bladder cancer DHEA DHEAS DHEA-S

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    low DHEA and DHEAS is associated with increased risk of bladder cancer in both sexes.  
Nathan Goodyear

Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ... - 0 views

erc.endocrinology-journals.org/...451.short

bladder cancer bladder cancer androgen receptor androgen receptors AR androgen receptor receptors EGFR epidermal growth factor receptor

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    Androgen receptors may be associated with bladder cancer progression.  This study finds AR up regulates Epidermal growth factor in bladder cancer cells.
Nathan Goodyear

Expression of androgen and oestrogen receptors and its prognostic significance in uroth... - 0 views

onlinelibrary.wiley.com/...abstract

AR androgen receptor androgen receptors androgen receptor ER alpha ER-alpha bladder cancer bladder cancer ER-beta ER beta hormone hormones

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    Study finds that loss of AR and ER-alpha is associated with high grade bladder cancer and ER-beta was positively associated. This has been contradicted by other studies.
Nathan Goodyear

Loss of androgen receptor expression is not associated with pathological stage, grade, ... - 0 views

onlinelibrary.wiley.com/...abstract

bladder cancer bladder cancer androgen receptor androgen receptors androgen receptor

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    multi-center study finds no association between androgen receptor expression and invasive bladder cancer.  There was also no difference between male and female in androgen receptor expression.
Nathan Goodyear

The benefits and risks of testosterone replacement therapy: a review - 0 views

www.ncbi.nlm.nih.gov/...PMC2701485

Testosterone therapy treatment low T low Testosterone men male hormone hormones

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    review article on risk/benefits of Testosterone therapy in men.
Nathan Goodyear

Expression and significance of androgen receptor coactivators in urothelial carcinoma o... - 0 views

erc.endocrinology-journals.org/...123.full

bladder cancer bladder cancer AR androgen receptor androgen receptor receptors hormones hormone androgen receptors

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    This study focused on coactivators in bladder cancer.  Although, the study found that AR expression was inversely associated with advancing bladder cancer stage--This is opposite from the positive correlation with Prostate Cancer.  
Nathan Goodyear

Expression of estrogen receptors-α and -β in bladder cancer cell lines and hu... - 0 views

onlinelibrary.wiley.com/...full

ER ER beta ER-beta bladder cancer bladder cancer

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    ER-beta is commonly expressed versus ER-alpha in bladder cancer.  There was a positive correlation between ER-beta expression and invasion and grade of cancer.  This study also found that blockade of the ER resulted in a decrease in growth.
Nathan Goodyear

Androgen Receptor Is a Potential Therapeutic Target for Bladder Cancer - Urology - 0 views

www.goldjournal.net/...fulltext

AR androgen receptor androgen receptors bladder cancer bladder cancer male men hormone hormones

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  • Nathan Goodyear on 04 Jan 15
     
    Study finds that a decrease in androgen receptor inhibits bladder cancer cell growth in vivo and in vitro studies.  
Nathan Goodyear

Androgen receptor expression is inversely correlated with pathologic tumor stage in bla... - 0 views

www.goldjournal.net/...abstract

androgen receptor androgen receptors bladder cancer bladder cancer men male hormone hormones AR

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  • Nathan Goodyear on 04 Jan 15
     
    Study finds that loss of Androgen receptors associated with advanced stage bladder cancer in men.
Nathan Goodyear

Promoting effects and mechanisms of action of androgen in bladder c... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9129932

bladder cancer bladder cancer Testosterone men male hormone hormones

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  • Nathan Goodyear on 04 Jan 15
     
    Another animal study finds Testosterone plays a role in bladder cancer development.  The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no.  The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.
Nathan Goodyear

Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals - 0 views

jnci.oxfordjournals.org/...558.full

bladder cancer bladder cancer androgen receptor androgen receptors AR receptor men male hormones hormone

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    Animal study finds that Androgen Receptors play role in bladder cancer development and progression in men.
Nathan Goodyear

http://ehp.niehs.nih.gov/wp-content/uploads/118/12/ehp.1002720.pdf - 0 views

ehp.niehs.nih.gov/...ehp.1002720.pdf

liver enzymes NAFLD liver disease cirrhosis hepatitis PCBs polychlorinated biphenyls Lead Pb Mercury Hg

shared by Nathan Goodyear on 22 Dec 14 - No Cached
  • Nathan Goodyear on 22 Dec 14
     
    PCBs, Lead, and Mercury associated with liver disease in American adults.  These possible causes need to be considered with non-explainable hepatitis.
Nathan Goodyear

European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views

www.nature.com/...ejcn2014158a.html

nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity

shared by Nathan Goodyear on 22 Dec 14 - No Cached
  • It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
  • An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
  • The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
  • ...8 more annotations...
  • Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
  • Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
  • increased adiposity, once established in childhood, tends to track into adulthood
  • Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
  • The acquisition of fat cells early in life appears to be an irreversible process
  • Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
  • In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
  • our systematic review highlights that most of the trials reviewed were prone to methodological limitations
  • Nathan Goodyear on 22 Dec 14
     
    Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy.  No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy.  No harm was found either.  Data was sparse.   Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3.  At this point not studies have pointed to reduced obesity in children.
Nathan Goodyear

Incidence of Prostate Cancer in Hypogonadal Men Receiving Testosterone Therapy: Observa... - 0 views

www.jurology.com/...fulltext

low t low Testosterone hypogonadism low T Testosterone men male hormone hormones prostate cancer therapy treatment

shared by Nathan Goodyear on 17 Dec 14 - No Cached
  • Nathan Goodyear on 17 Dec 14
     
    Study of 3 cohorts with a median of 5 years of Testosterone therapy in men with low T, finds no increase risk in prostate cancer.
Nathan Goodyear

Program Planner | Presentation - 0 views

www.abstractsonline.com/pp8

CAD cardiovascular disease women hormone hormones Estradiol progesterone BHRT bio-identical hormones female

shared by Nathan Goodyear on 16 Dec 14 - No Cached
  • Nathan Goodyear on 16 Dec 14
     
    Just an abstract from the Presentation at the 2014 Scientific Session. The abstract points to a 40% reduction in CAD with the onset of BHRT (Estradiol and progesterone topical) within 6 years of menopause compared to women 10 years post-menopause.  This points to timing as a critical component of BHRT in women and CAD.
Nathan Goodyear

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphi... - 0 views

www.ncbi.nlm.nih.gov/...PMC3901602

cannabis ALL leukemia hemp oil CBD THC cancer

shared by Nathan Goodyear on 15 Dec 14 - No Cached
  • Nathan Goodyear on 15 Dec 14
     
    Case study of a 14 year old treated with hemp oil for ALL.
Nathan Goodyear

British Journal of Cancer - A pilot clinical study of [Delta]9-tetrahydrocannabinol in ... - 0 views

www.nature.com/...6603236a.html

THC cannabinoids cancer Tetrahydrocannabinol CBD

shared by Nathan Goodyear on 15 Dec 14 - No Cached
  • Nathan Goodyear on 15 Dec 14
     
    Pilot study of THC for advanced, recurrent glioblastoma multiforme.  The infused THC appeared to be safe and provide some anti proliferative activity, but all patients died within 1 year.
Nathan Goodyear

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells - 0 views

mct.aacrjournals.org/...2921.full

breast cancer cancer CBD cannabidiol

shared by Nathan Goodyear on 15 Dec 14 - No Cached
  • Nathan Goodyear on 15 Dec 14
     
    CBD downregulates Id-1 gene activity in vitro and in vivo in breast cancer cell cultures.
Nathan Goodyear

http://download.springer.com/static/pdf/242/art%253A10.1007%252Fs10549-010-1177-4.pdf?a... - 0 views

download.springer.com/...1007%252Fs10549-010-1177-4.pdf

CBD cancer cannabidiol breast cancer

shared by Nathan Goodyear on 15 Dec 14 - No Cached
  • Nathan Goodyear on 15 Dec 14
     
    CBD reduces breast cancer proliferation, invasion, and metastasis.  Analysis was via human cell cultures.
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