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Nathan Goodyear

Association between circulating specific leukocyte types and blood pressure: the Atherosclerosis Risk in Communities (ARIC) study - 0 views

www.ashjournal.com/...abstract

hypertension blood pressure blood pressure inflammation

shared by Nathan Goodyear on 25 Sep 12 - No Cached
  • Nathan Goodyear on 25 Sep 12
     
    Blood pressure is a s symptom of inflammation.  In this study it was found that elevated neutrophils and decreased lymphocytes was associated with hypertension in the African American population
Nathan Goodyear

JSTOR: Epidemiology, Vol. 13, No. 4 (Jul., 2002), pp. 454-458 - 0 views

www.jstor.org/...3703770

DDE environmental toxins low T testosterone men endocrine disruptors

shared by Nathan Goodyear on 21 May 12 - No Cached
  • Nathan Goodyear on 21 May 12
     
    High DDE levels in African American men associated with a 23% lower Testosteone levels
Nathan Goodyear

Vitamin D deficiency and insulin ... [J Pediatr Endocrinol Metab. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21528812

vitamin vitamin d insulin resistance diabetes DM obesity overweight adiponectin

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    vitamin D associated with low adiponectin, obesity and insulin resistance in african Americans
Nathan Goodyear

Effect of Vitamin D Supplementation on Blood Pressure in BlacksNovelty and Significance - 0 views

hyper.ahajournals.org/...779.abstract

vitamin D blood pressure hypertension Black african american

shared by Nathan Goodyear on 19 Mar 13 - No Cached
  • Nathan Goodyear on 19 Mar 13
     
    Vitamin D therapy in Black people with hypertension shown to decrease blood pressure statistically, though small.
Nathan Goodyear

Maternal and Cord Steroid Sex Hormones, Angiogenic Factors and Insulin-like Growth Factor Axis in African-American Preeclamptic and Uncomplicated Pregnancies - 0 views

www.ncbi.nlm.nih.gov/...PMC3636811

androgens Testosterone androstenedione women sex hormones cardiovascular disease CVD preeclampsia

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    Women with elevated androgens, Testosterone and androstenedione, are at higher risk of preeclampsia.  This translates to a higher risk of CVD in women later in life, post pregnancy.  This fits with other literature that CVD is linearly associated with a rising Testosterone.  This has been found in caucasian and black women.
Nathan Goodyear

Evidence that Increased Ovarian Aromatase Activity and Expression Account for Higher Estradiol Levels in African American Compared With Caucasian Women - 0 views

jcem.endojournals.org/...jc.2013-2398.abstract

Ovary aromatase women hormone hormones

shared by Nathan Goodyear on 01 Dec 13 - No Cached
  • Nathan Goodyear on 01 Dec 13
     
    Study highlights the differences of estrogen production, between black and white women, due to peripheral aromatase activity.  Again highlighting the importance of customized health care and the uselessness of serum hormones.  The function is occurring in the tissue, not the serum.
Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views

www.ajandrology.com/article.asp

Testosterone metabolic syndrome MetS TT total Testosterone SHBG men male hormone hormones Estradiol insulin resistance

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
  • Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
  • Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
  • ...20 more annotations...
  • Low TT and SHBG levels also are prevalent in Chinese [7],[8] and Korean [9] men with the MetS
  • Normally 40%-50% of TT is bound to SHBG, so reducing SHBG levels will decrease TT.
  • Hyperinsulinism suppresses SHBG synthesis and secretion by the liver
  • significant increase in SHBG levels occurred after acutely lowering insulin levels in obese men
  • Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
  • Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
  • Estradiol also can inhibit luteinizing hormone (LH) secretion
  • Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
  • Low TT Levels have been shown to predict development of the MetS in men with normal BMI
  • Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
  • More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
  • Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
  • Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
  • combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
  • in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
  • Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
  • The evidence that TRT improves insulin sensitivity and glucose control is conflicted
  • It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
  • Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
  • Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
  • Nathan Goodyear on 02 Mar 15
     
    To be read article on Testosterone and Metabolic Syndrome.
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