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male mouse model finds estrogen can induce prostatitis and dysplasia of the prostate.

Validation of salivary testosterone as a screening test for male hypogonadism.

Changes in male salivary testosterone concentration with age

antioxidants as part of infertility treatment? yes.

HCG and clomid stimulation tests helpful in differentiating male hypogonadism

New study finds Testosterone therapy provides less than statistical significant improvement in constitutional/sexual symptoms, in obese men with type II diabetes with symptoms classified as mild-moderate with modest reductions in Total Testosterone.  This study highlights that low Testosterone is a biomarker of poor health and multiple comorbidities and that simply adding in Testosterone therapy will not cure all male woes.  The authors did state that ED and low T are separate issues and I will differ with them on this--they are in fact link.  This association may vary between individuals, but to flatly state they are completely separate issues is devoid of the fact that testosterone has been shown to reduce inflammatory cytokines and improve PDE5 therapy.  

MMAS study finds an age associated decline in Total Testosterone and free Testosterone levels. This study focus on the % decline based on other variables i.e. age, BMI...IN contrast, a 3.5% rise in DHT levels were observed. There is debate about the correlation of serum DHT and intra-tissue DHT. In fact, studies suggest there is little correlation.

Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.

Men with Obesity are found to have lower SHBG and Testosterone levels.  This study found that suppression of insulin resulted in an increase in SHBG production from the liver in both obese and normal weight men.  Of note, the decrease in insulin resulted in a decrease in male Testosterone in both normal weight and obese men.

Low Testosterone is common among male cancer survivors after therapy.  Many studies point to low T at the time of diagnosis as a prognostic biomarker.  The low T impairs QOL in this men.

Animal model finds that Testosterone improves ventricular remodeling and function following myocardial infarction in male rats.  This similar finding has been found in human studies as well.   Testosterone therapy was found to lower BNP in this rat study.

interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.

The problem of male infertility continues to grow. New study finds that from 1973 to 2011, sperm count among men in North America, Europe, Australia, and New Zealand drop by 50-60%.

Male health is an important issue that directly affects the well-being of families and labor productivity in the whole society. Today, with the negative changes of the environment and work pressures, many diverse and complex male pathologies have arisen. However, while gynecological examinations are performed periodically by women, male medical examination is often not respected by men because of the subjectivity as well as reservations about psychology.

Massachusetts Male Aging Study (MMAS).

Bisphenol A downgregulates ER-beta in male prostate.  This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications  in prostate health.

This study found that in longitudinal studies, testosterone decline accelerated compared to cross sectional studies.  They concluded that decreasing health could be the explanation.  But, what if the decline in testosterone explained the decreasing health?

weight gain and obesity are associated with a dysfunctional HPA axis and low testosterone in men.  Reduction in weight will restore HPA axis function.

Older analysis, but this shows the suspect and literature, supporting an environmental component to declining testosterone levels in me.

good review of the effect of environmental xenoestrogens and low T in men.