lower 25(OH)D level was significantly associated with lower total T, E2, SHBG, LH and FSH levels after adjusting for age, residence area, economic status and current smoker
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Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from... - 0 views
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association between 25(OH)D status and hypogonadism in Chinese men and confirms that this relationship is present in a large population
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VDR knockout mutant mice showed gonadal insufficiencies
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High LH and FSH levels in the male mice indicated hypergonadotropic hypogonadism
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Another mouse study reported a tendency towards low testosterone/LH ratio and Leydig cell hyperplasia in VDR null mice
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The serum testosterone levels could increase to normal values in vitamin D-deficient rats replete with vitamin D
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VDR knockout mice had decreased sperm count, reduced sperm motility, and histological abnormality of the testis
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vitamin D supplementation increases testosterone levels in non-diabetic subjects
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The data from the European Male Ageing Study [9] indicated that 25(OH)D is positively associated with total T
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Study of 713 Chinese men finds a correlation between low vitamin D and low total Testosterone.
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shared by Nathan Goodyear on 04 Feb 14
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Testosterone and glucose metabolism in men: current concepts and controversies - 0 views
joe.endocrinology-journals.org/...R37.full
Low T Testosterone metabolic syndrome MetS Diabetes men male glucose hormone hormones g
shared by Nathan Goodyear on 04 Feb 14
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Around 50% of ageing, obese men presenting to the diabetes clinic have lowered testosterone levels relative to reference ranges based on healthy young men
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The absence of high-level evidence in this area is illustrated by the Endocrine Society testosterone therapy in men with androgen deficiency clinical practice guidelines (Bhasin et al. 2010), which are appropriate for, but not specific to men with metabolic disorders. All 32 recommendations made in these guidelines are based on either very low or low quality evidence.
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A key concept relates to making a distinction between replacement and pharmacological testosterone therapy
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The presence of symptoms was more closely linked to increasing age than to testosterone levels
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Findings similar to type 2 diabetes were reported for men with the metabolic syndrome, which were associated with reductions in total testosterone of −2.2 nmol/l (95% CI −2.41 to 1.94) and in free testosterone
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low testosterone is more predictive of the metabolic syndrome in lean men
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Cross-sectional studies uniformly show that 30–50% of men with type 2 diabetes have lowered circulating testosterone levels, relative to references based on healthy young men
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In a recent cross-sectional study of 240 middle-aged men (mean age 54 years) with either type 2 diabetes, type 1 diabetes or without diabetes (Ng Tang Fui et al. 2013b), increasing BMI and age were dominant drivers of low total and free testosterone respectively.
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both diabetes and the metabolic syndrome are associated with a modest reduction in testosterone, in magnitude comparable with the effect of 10 years of ageing
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In a cross-sectional study of 490 men with type 2 diabetes, there was a strong independent association of low testosterone with anaemia
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In men, low testosterone is a marker of poor health, and may improve our ability to predict risk
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low testosterone identifies men with an adverse metabolic phenotype
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Diabetic men with low testosterone are significantly more likely to be obese or insulin resistant
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increased inflammation, evidenced by higher CRP levels
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Bioavailable but not free testosterone was independently predictive of mortality
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It remains possible that low testosterone is a consequence of insulin resistance, or simply a biomarker, co-existing because of in-common risk factors.
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In prospective studies, reviewed in detail elsewhere (Grossmann et al. 2010) the inverse association of low testosterone with metabolic syndrome or diabetes is less consistent for free testosterone compared with total testosterone
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In a study from the Framingham cohort, SHBG but not testosterone was prospectively and independently associated with incident metabolic syndrome
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low SHBG (Ding et al. 2009) but not testosterone (Haring et al. 2013) with an increased risk of future diabetes
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In cross-sectional studies of men with (Grossmann et al. 2008) and without (Bonnet et al. 2013) diabetes, SHBG but not testosterone was inversely associated with worse glycaemic control
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SHBG may have biological actions beyond serving as a carrier protein for and regulator of circulating sex steroids
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In men with diabetes, free testosterone, if measured by gold standard equilibrium dialysis (Dhindsa et al. 2004), is reduced
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Low free testosterone remains inversely associated with insulin resistance, independent of SHBG (Grossmann et al. 2008). This suggests that the low testosterone–dysglycaemia association is not solely a consequence of low SHBG.
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Experimental evidence reviewed below suggests that visceral adipose tissue is an important intermediate (rather than a confounder) in the inverse association of testosterone with insulin resistance and metabolic disorders.
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testosterone promotes the commitment of pluripotent stem cells into the myogenic lineage and inhibits their differentiation into adipocytes
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testosterone regulates the metabolic functions of mature adipocytes (Xu et al. 1991, Marin et al. 1995) and myocytes (Pitteloud et al. 2005) in ways that reduce insulin resistance.
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Pre-clinical evidence (reviewed in Rao et al. (2013)) suggests that at the cellular level, testosterone may improve glucose metabolism by modulating the expression of the glucose-transported Glut4 and the insulin receptor, as well as by regulating key enzymes involved in glycolysis.
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More recently testosterone has been shown to protect murine pancreatic β cells against glucotoxicity-induced apoptosis
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Interestingly, a reciprocal feedback also appears to exist, given that not only chronic (Cameron et al. 1990, Allan 2013) but also, as shown more recently (Iranmanesh et al. 2012, Caronia et al. 2013), acute hyperglycaemia can lower testosterone levels.
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There is also evidence that testosterone regulates insulin sensitivity directly and acutely
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In men with prostate cancer commencing androgen deprivation therapy, both total as well as, although not in all studies (Smith 2004), visceral fat mass increases (Hamilton et al. 2011) within 3 months
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More prolonged (>12 months) androgen deprivation therapy has been associated with increased risk of diabetes in several large observational registry studies
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Testosterone has also been shown to reduce the concentration of pro-inflammatory cytokines in some, but not all studies, reviewed recently in Kelly & Jones (2013). It is not know whether this effect is independent of testosterone-induced changes in body composition.
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the observations discussed in this section suggest that it is the decrease in testosterone that causes insulin resistance and diabetes. One important caveat remains: the strongest evidence that low testosterone is the cause rather than consequence of insulin resistance comes from men with prostate cancer (Grossmann & Zajac 2011a) or biochemical castration, and from mice lacking the androgen receptor.
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Several large prospective studies have shown that weight gain or development of type 2 diabetes is major drivers of the age-related decline in testosterone levels
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there is increasing evidence that healthy ageing by itself is generally not associated with marked reductions in testosterone
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Circulating testosterone, on an average 30%, is lower in obese compared with lean men
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increased visceral fat is an important component in the association of low testosterone and insulin resistance
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The vast majority of men with metabolic disorders have functional gonadal axis suppression with modest reductions in testosterone levels
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obesity is a dominant risk factor
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men with Klinefelter syndrome have an increased risk of metabolic disorders. Interestingly, greater body fat mass is already present before puberty
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Only 5% of men with type 2 diabetes have elevated LH levels
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inhibition of the gonadal axis predominantly takes place in the hypothalamus, especially with more severe obesity
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Metabolic factors, such as leptin, insulin (via deficiency or resistance) and ghrelin are believed to act at the ventromedial and arcuate nuclei of the hypothalamus to inhibit gonadotropin-releasing hormone (GNRH) secretion from GNRH neurons situated in the preoptic area
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kisspeptin has emerged as one of the most potent secretagogues of GNRH release
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hypothesis that obesity-mediated inhibition of kisspeptin signalling contributes to the suppression of the HPT axis, infusion of a bioactive kisspeptin fragment has been recently shown to robustly increase LH pulsatility, LH levels and circulating testosterone in hypotestosteronaemic men with type 2 diabetes
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A smaller study with a similar experimental design found that acute testosterone withdrawal reduced insulin sensitivity independent of body weight, whereas oestradiol withdrawal had no effects
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suppression of the diabesity-associated HPT axis is functional, and may hence be reversible
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Obesity and dysglycaemia and associated comorbidities such as obstructive sleep apnoea (Hoyos et al. 2012b) are important contributors to the suppression of the HPT axis
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weight gain and development of diabetes accelerate the age-related decline in testosterone
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Modifiable risk factors such as obesity and co-morbidities are more strongly associated with a decline in circulating testosterone levels than age alone
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55% of symptomatic androgen deficiency reverted to a normal testosterone or an asymptomatic state after 8-year follow-up, suggesting that androgen deficiency is not a stable state
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Weight loss can reactivate the hypothalamic–pituitary–testicular axis
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Leptin treatment resolves hypogonadism in leptin-deficient men
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The hypothalamic–pituitary–testicular axis remains responsive to treatment with aromatase inhibitors or selective oestrogen receptor modulators in obese men
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Kisspeptin treatment increases LH secretion, pulse frequency and circulating testosterone levels in hypotestosteronaemic men with type 2 diabetes
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change in BMI was associated with the change in testosterone (Corona et al. 2013a,b).
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weight loss can lead to genuine reactivation of the gonadal axis by reversal of obesity-associated hypothalamic suppression
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There is pre-clinical and observational evidence that chronic hyperglycaemia can inhibit the HPT axis
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in men who improved their glycaemic control over time, testosterone levels increased. By contrast, in those men in whom glycaemic control worsened, testosterone decreased
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testosterone levels should be measured after successful weight loss to identify men with an insufficient rise in their testosterone levels. Such men may have HPT axis pathology unrelated to their obesity, which will require appropriate evaluation and management.
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Article discusses the expanding evidence of low T and Metabolic syndrome.
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Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic rev... - 0 views
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large meta analysis finds low Total Testosterone associated with in men and high Total Testosterone associated with MetS in women. lower SHBG is associated with MetS
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Manual Wheelchairs - 0 views
www.wheelchairindia.com/...BASIC-WHEELCHAIR
Comfort Manual And Basic Wheelchair easy to transport permanent arm styles Basic Wheelchair Manual Wheelchairs pushing on round bars
shared by wheelchairindia9 on 15 May 15
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Manual wheelchairs are the type that require people to move them, there are three types of manual wheelchairs namely self-propelled, attendant propelled, and wheelbase. Many manual chairs can be folded wheelchairs for storage or movement into a vehicle. A manual wheelchair is one that is propelled by the user. It is usually done by pushing on round bars that surround the wheels. This wheelchair also has handles on the back so it can be pushed by another person. A manual wheelchair is easy to maintain, is lightweight, and is the least expensive to buy. Manual wheelchairs that cater to many different conditions that a user may have. Manual wheelchairs includes a large selection of high quality chairs that are highly competitive in price. It carry many different categories of wheelchairs, depending on condition can find one that best fits lifestyle. Manual Wheelchairs are the type of device that a person must move themselves without the assistance of a battery. It choose from self-propel, which requires the user to propel with the use of their limbs, and companion propelled, which means that must have a person to push. It believe that users will be able to find the best manual wheelchair available for their specific needs. A lightweight manual wheelchair offers a combination of safety and durability with convenient features such as flip-back armrests and swingaway footrests for easier transfers, and height-adjustable rear wheels. It is available in self-propelled and attendant-assisted versions, and can be quickly demounted for easier transportation. It has quick release rear wheels, swing away and detachable armrests, swing in/out footrests, puncture proof tyres, fitted lap belt, folding backrest and lightweight, padded nylon upholstery. Karma Econ 800 Wheelchair The new multi-adjustable ECON 800 is a quality, lightweight aircraft grade aluminium alloy frame wheelchair. The swing-away and detachable footrest's calf length can be adjusted to fit your bod
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shared by wheelchairindia9 on 11 Sep 15
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Karma Aurora 4 - 0 views
disabilityproduct.in/...-Aurora-4-Reclining-Wheelchair
Karma Aurora 4 Reclining Wheelchair Detachable with calf support for added comfort Hand brakes Fordable Karma Aurora 4
shared by wheelchairindia9 on 11 Sep 15
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Karma Aurora 4 Reclining Wheelchair Frame Style : Fordable Frame Material : Aluminium (Light weight) Seat Width (inches) : 18" Total width in wheel to wheel : 11" Rear Wheel Size : 24" Front Wheel Size : 7" Seat to floor height (inches) : 20" Seat Depth (inches) : 16" Back height (inches) : 35" Total height (inches) : 50" Max User Weight Capacity (kgs) : 120 Frame Net Weight (kgs) : 13.5 k.g. Upholstery : Cloth water-proof. Armrest : Detachable, for easy transfer to bed. Leg-rest : Detachable, can also be elevated & with calf support for added comfort Wheel Quality : MAG WHEEL Rear Wheel Brakes : Available Hand brakes : Available
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shared by wheelchairindia9 on 10 Oct 15
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Karma Km 2500 Wheelchair - 0 views
www.disabilityproduct.in/...KM-2500-Small-Wheel-Wheelchair
Foldable Frame Karma KM 2500 Wheelchair compact transit wheelchair karma km 2500 wheelchair Puncture proof tyres double cross bars Comfortable karma km 2500 L wheelchair outstanding strength and durability
shared by wheelchairindia9 on 10 Oct 15
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Travel Wheelchairs are usually designed for being as lightweight as is possible for the health of performance or maybe portability. People exactly who travel frequently because of their wheelchairs by means of car or maybe airplane roommates wish a wheelchair is not just lightweight but takes the least number of space doable. Travel information wheelchairs are classified as the most sleek and stylish, lightweight collapsible wheelchairs. The lightest wheelchairs do not need some on the accessories a usual manual wheelchair often have, but almost all models is usually customized to add in items like fold-away footrests in addition to adjustable buttocks. Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and travelers. It folds down to take up virtually no space in the boot of a car and weighs just over 9.2 kg making it easy for anyone to lift into
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shared by Nathan Goodyear on 15 Sep 15
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Association of sex hormones and C-reactive protein levels in men - 0 views
www.ncbi.nlm.nih.gov/...PMC2866020
male men hormones CRP inflammation cytokine Testosterone SHBG estradiol estrogen
shared by Nathan Goodyear on 15 Sep 15
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Low total Testosterone, low free Testosterone, and low SHBG associated with increased CRP. Serum total estradiol and free estradiol trended to a positive association, but did not reach statistical significance.
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shared by wheelchairindia9 on 22 Sep 15
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Transporter Wheelchair - 0 views
www.disabilityproduct.in/...TRAVEL-WHEELCHAIR
Adjustable Backrests Travel Wheelchairs addition to adjustable buttocks Transporter Wheelchair front caster outriggers pumping the lever back and forth Lightweight Transport Wheelchair
shared by wheelchairindia9 on 22 Sep 15
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Lightweight aluminium wheelchairs available that fold down for easy transportation and storage. These compact travel folding wheelchairs fit neatly into the boot of a car and are ideal for use on holiday, for days out or for short shopping trips. Known as travel wheelchairs, fold-up wheelchairs, foldaway wheelchairs these compact travel folding wheelchairs fits neatly into the boot of a car. The Light Travel Wheelchair is an ultra lightweight aluminium wheelchairs which fold into its own bag for easy transportation and storage. The chair seat size (width and depth), seat-to-floor height, footrests/leg rests, front caster outriggers, adjustable backrests, controls, and many other features can be customized on, or added to, many basic models, while some users, often those with specialised needs, may have wheelchairs custom-built. Karma KM 2500 L Big Wheel Wheelchair: Karma KM 2500 L Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 22" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 11.kg Karma KM 2500 L Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 L Wheelchair Extended Armrest By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (11 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 L Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and t
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shared by Nathan Goodyear on 21 May 15
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Elderly men over 65 years of age with late-onset hypogonadism benefit as much from test... - 0 views
www.ncbi.nlm.nih.gov/...PMC4392031
low T low Testosterone Testosterone men male hormone hormones late onset hypogonadism hypogonadism
shared by Nathan Goodyear on 21 May 15
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The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
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obesity, but also impaired general health, are the more common causes of low testosterone in aging men
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Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
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advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
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Diabetes mellitus was correlated with hypogonadism in most studies
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coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
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LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
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the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.
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Mean weight decreased
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Waist circumference decreased
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Total cholesterol decreased
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Low-density lipoprotein decreased
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Triglycerides decreased
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High-density lipoprotein (HDL) increased
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ratio of total cholesterol to HDL improved
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Prostate volume increased
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PSA increased
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The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
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weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
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Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
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observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
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the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
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The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
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it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
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Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
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Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
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These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
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The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
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Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
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This apparent paradox is explained by the "saturation model,"
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Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
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In the present observational study, no cases of major adverse cardiovascular events occurred.
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the benefits of testosterone therapy are fully achieved only by long-term treatment
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To achieve maximal benefits, good patient adherence is a prerequisite
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Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
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ScienceDirect - American Heart Journal : Plasma total cysteine and total homocysteine a... - 0 views
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Fasting homocysteine was positively associated with MI risk
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Fasting plasma concentration of total homocysteine, but not total cysteine, was positively associated with MI risk.
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shared by Nathan Goodyear on 08 Jan 14
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Association of serum testosterone with lipid abnormalities in patients with angiographi... - 0 views
www.ncbi.nlm.nih.gov/...PMC3872686
Testosterone male men hormone hormones lipids HDL LDL cholesterol CAD coronary artery disease coronary heart disease
shared by Nathan Goodyear on 08 Jan 14
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This study looked at Total serum Testosterone and lipid profiles in men with CAD. What they found is that serum Total Testosterone is positively associated with HDL and negatively associated with LDL.
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shared by Nathan Goodyear on 20 May 14
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Semen quality, infertility and mortality in the USA - 0 views
humrep.oxfordjournals.org/...humrep.deu106
infertility semen sperm mortality men male men's health health wellness
shared by Nathan Goodyear on 20 May 14
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Men with infertility associated with 2.3 fold higher risk of death. The factors evaluated were semen volume, sperm concentration, sperm motility, total sperm count, total motile sperm count. Those that have 2 or more positive parameters were associated with increased death compared to those with normal semen analysis.
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shared by Nathan Goodyear on 29 Jul 14
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Total and free testosterone concentrat... [Clin Endocrinol (Oxf). 2012] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...21854402
low T Testosterone diabetes obesity age men male hormone hormones free Testosterone total Testosterone ED QOl
shared by Nathan Goodyear on 29 Jul 14
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Testosterone levels appear to be more of a biomarker of poor health in older men that are obese with diabetes. More of these men had low free Testosterone (calc) versus Total Testosterone. Using QOL questionnaires, weak correlation (not statistically significant) with androgen deficiency symptoms and ED were found.
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shared by Nathan Goodyear on 24 Jul 14
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Endocrine screening for sexual dysfunction using free... [J Urol. 1996] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...8683690
free Testosterone free Total total Testosterone Testosterone low T ED men male hormone hormones
shared by Nathan Goodyear on 24 Jul 14
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free Testosterone proves more useful than serum Total Testosterone, symptom questionnaire and testicular atrophy in the diagnosis of hypogonadism in men with ED.
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shared by Nathan Goodyear on 03 Sep 14
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Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Link... - 0 views
press.endocrine.org/...jc.2007-1972
low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG
shared by Nathan Goodyear on 03 Sep 14
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0.4–2% annual decline
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the age trend in free T was more substantial (−1.3% per annum)
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The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
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Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
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our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
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a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
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This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
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the effects of aging on testicular function can be moderated by increased LH compensation for many decades
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obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
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the concurrent but opposite (and separate) effects of obesity and age on SHBG
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SHBG was negatively associated with increasing strata of obesity
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Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
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the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
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Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
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The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
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chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
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increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
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the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
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It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
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Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated. In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low. The pulse amplitude is decrease. No change in pulse frequency is noted. With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
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shared by Nathan Goodyear on 27 Jan 15
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International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views
www.nature.com/...ijir200842a.html
low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity
shared by Nathan Goodyear on 27 Jan 15
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Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
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testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
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In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
- ...12 more annotations...
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In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
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testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
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Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
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testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
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Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
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available data clearly show a relationship between obesity, low testosterone levels and ED
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Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
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Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
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The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
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Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
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Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
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epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
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shared by Nathan Goodyear on 02 Feb 15
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ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views
www.ncbi.nlm.nih.gov/...PMC3428144
hormone hormones Testosterone Estradiol Estrogen women CVD cardiovascular disease female SHBG hypertension post-menopause blood pressure
shared by Nathan Goodyear on 02 Feb 15
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Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
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T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
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SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
- ...8 more annotations...
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SHBG has been postulated as a marker for insulin resistance
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In vitro studies showed that insulin inhibits SHBG production from hepatoma cells
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In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
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E2 may also induce insulin resistance and thereafter tend to raise BP.
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strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
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In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
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estrone levels were positively associated with inflammatory markers in postmenopausal women
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higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up
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Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.
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shared by Nathan Goodyear on 06 Aug 14
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Both total testosterone and sex hormone-binding globulin are independent risk factors f... - 0 views
onlinelibrary.wiley.com/...abstract
metabolic syndrome men male hormone hormones Total Testosterone free bioavailable SHBG low T low Testosterone
shared by Nathan Goodyear on 06 Aug 14
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Study of 2361 Chinese men found that men with MetS had lower TT, bioavailable Testosterone, free Testosterone and SHBG than those men without MetS. Additionally, Total Testosterone and SHBG were both inversely associated with the risk of MetS. This inverse association stood for both after adjusting for the other.
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shared by wheelchairindia9 on 14 Apr 15
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Types of Heavy Duty Wheelchair and Its Features - 0 views
www.articlesbase.com/...-and-its-features-7243370.html
Karma 8020 X Heavy Duty Wheelchair Karma 8520 Heavy Duty Wheelchair Heavy Duty Wheelchair Features types of Heavy Duty Wheelchair Heavy Duty Wheelchair for handicapped Bariatric Wheelchair
shared by wheelchairindia9 on 14 Apr 15
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Heavy Duty Wheelchair specialy design for disabled and handicapped persons. They two types of Heavy Duty Wheelchair for handicapped and disability product like- Karma 8020 X Heavy Duty Wheelchair Karma 8520 Heavy Duty Wheelchair Karma 8020 X Heavy Duty Wheelchair Karma 8020 or Karma KM-8020 Heavy Duty Wheelchair specialy design for disabled and handicapped persons. Some features are mentioned below- Features It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Karma 8020 X Heavy Duty Wheelchair Item Code and Price Item Code: WCI-52 MRP: Rs 45162 Our Price: Rs 32900 Net Price: Rs 32242( Apply Coupon Code 'MSW2365' Get 2% Discount ) Karma 8520 Heavy Duty Wheelchair Karma 8520 or Karma KM-8520 Heavy Duty Wheelchair specialy design for disabled and handicapped persons. Some features are mentioned below- Features It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Karma 8520 Heavy Duty Wheelchair Item Code and Price Item Code: WCI-29 MRP: Rs 32085 Our Price: Rs 24063 Net Price: Rs 23582( Apply Coupon Code 'MSW2365' Get 2% Discount ) Heavy Duty Wheelchair Online Purchases: This Website is only a venue where Users may meet and interact with us for their sale and purchase transactions. The commercial / contractual terms include without limitation price, shipping costs, date, period, mode of delivery, warranties related to products and services including after sales services related to product(s) and services, etc., over which we have complete control and same may be the subject to change. The agreement between you and wheelchairindia.com is subject to the following terms and cond