Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views
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Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
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No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
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a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
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Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis. Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L. The IV groups maintained elevated serum C levels for up to 96 hours post infusion.