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Nathan Goodyear

https://www.jstage.jst.go.jp/article/jcbn/58/1/58_15-48/_pdf - 0 views

www.jstage.jst.go.jp/..._pdf

lifestyle Testosterone low T low Testosterone exercise nutrition hormones obesity overweight

shared by Nathan Goodyear on 25 Jan 16 - No Cached
  • Nathan Goodyear on 25 Jan 16
     
    study finds that lifestyle interventions, aerobic exercise and calorie restriction, increased Testosterone levels in men that were overweight or obese.  The men included in this study did not meet most definitions of "low Testosterone".
wheelchairindia9

Hip Cycle - 0 views

www.wheelchairindia.com/...Hip-Cycle

Hip Cycle buy hip cycle exerciser hip cycle exerciser Vissco Hip Cycle Exerciser Vissco Hip Cycle hip cycles new hip cycle exerciser new hip cycle hip cycle home exerciser

shared by wheelchairindia9 on 24 Feb 16 - No Cached
  • wheelchairindia9 on 24 Feb 16
     
    Hip Cycle is a stationary regular cycle exerciser used in physical therapy and as a sports fitness aid. Cycling is a low-impact exercise to increase muscle strength and mobility of the hips and knees. Cycling assists in hip toning by muscle growth and burning of calories. Hip Cycle Features Pedaling uses thigh muscles: quadriceps to push down, and hamstrings to pull up during the circular motion Cycling workout results in isometric engagement of the abdomen as a supporting muscle group Range of motion exercises help improve joint function Reduce hip pain caused by bone diseases such as osteoarthritis and necrosis Hip Cycle can be used in preferably recumbent position or in sitting position
Nathan Goodyear

A Randomized Pilot Trial of a Moderate Carbohydrate Diet Compared to a Very Low Carbohydrate Diet in Overweight or Obese Individuals with Type 2 Diabetes Mellitus or Prediabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC3981696

diabetes ketogenic diet nutrition diet obesity

shared by Nathan Goodyear on 09 Feb 16 - No Cached
  • Nathan Goodyear on 09 Feb 16
     
    low carb ketogenic diet, high in fat worked better in glycemic control versus DA low fat, medium carbohydrate, calorie restricted diet.
fnfdoc

Causes And Treatment Of Obesity | Your Health Our Priority - 0 views

www.fnfdoc.com/...causes-treatment-obesity

BMI Obesity Causes Treatment

shared by fnfdoc on 01 May 18 - No Cached
  • fnfdoc on 01 May 18
     
    Read how to measure weight and take healthy steps for reducing fats. Obesity is excess of your calories stored in adipose tissues as fats. BMI is used for calculating body mass in relation to stronger muscles.
Nathan Goodyear

Frontiers | Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up | Nutrition - 0 views

www.frontiersin.org/...full

press-pulse therapy hyperbaric ketogenic metabolic therapy cancer ketogenic diet Glioblastoma glioblastoma multiforme HBOT nutrition

shared by Nathan Goodyear on 01 Apr 18 - No Cached
  • The SOC for GBM was modified in this patient to initiate KMT prior to surgical resection, to eliminate steroid medication, and to include HBOT as part of the therapy
  • the greatest therapeutic benefit for patients (near 1.0)
  • The observed reduction in blood glucose in our patient would reduce lactic acid fermentation in the tumor cells, while the elevation of ketone bodies would fuel normal cells thus protecting them from hypoglycemia and oxidative stress
  • ...30 more annotations...
  • Previous studies showed that GBM survival and tumor growth was correlated with blood glucose levels
  • Evidence indicates that glioma cells cannot effectively use ketone bodies for energy due to defects in the number, structure, and function of their mitochondria
  • The accuracy of the GKI as a predictor for therapeutic efficacy, however, is better when ketone bodies are measured from the blood than when measured from the urine
  • A reduction of glucose-driven lactic acid fermentation would not only increase tumor cell apoptosis, but would also reduce inflammation and edema in the tumor microenvironment thus reducing tumor cell angiogenesis and invasion
  • Besides serving as a metabolic fuel for GBM, glutamine is also an essential metabolite for normal immune cells
  • therapies that inhibit glutamine availability and utilization must be strategically employed to avoid inadvertent impairment of immune cell functions
  • we used the non-toxic green tea extract, EGCG, and chloroquine in an attempt to limit glutamine availability to the tumor cells
  • EGCG is thought to target the glutamate dehydrogenase activity that facilitates glutamine metabolism in GBM cells
  • Chloroquine, on the other hand, will inhibit lysosomal digestion thus restricting fermentable amino acids and carbohydrates from phagocytosed materials in the tumor microenvironment
  • HBOT to increase oxidative stress in the tumor cells
  • As glucose and glutamine fermentation protect tumor cells from oxidative stress, reduced availability of these metabolites under ketosis could enhance the therapeutic action of HBOT, as we recently described
  • Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast
  • Following the fast, the patient initiated a vitamin/mineral-supplemented ketogenic diet (KD) for 21 days that delivered 900 kcal/day
  • KD (increased to 1,500 kcal/day at day 22
  • the patient received metformin (1,000 mg/day), methylfolate (1,000 mg/day), chloroquine phosphate (150 mg/day), epigallocatechin gallate (400 mg/day), and hyperbaric oxygen therapy (HBOT) (60 min/session, 5 sessions/week at 2.5 ATA)
  • Biomarkers showed reduced blood glucose and elevated levels of urinary ketones with evidence of reduced metabolic activity (choline/N-acetylaspartate ratio) and normalized levels of insulin, triglycerides, and vitamin D
  • This is the first report of confirmed GBM treated with a modified SOC together with KMT and HBOT, and other targeted metabolic therapies
  • Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers
  • less than 20% of younger adults generally survive beyond 24 months
  • glucose and glutamine are the primary fuels that drive the rapid growth of most tumors including GBM
  • Glucose drives tumor growth through aerobic fermentation (Warburg effect), while glutamine drives tumor growth through glutaminolysis
  • The fermentation waste products of these molecules, i.e., lactic acid and succinic acid, respectively, acidify the tumor microenvironment thus contributing further to tumor progression
  • Glucose and glutamine metabolism is also responsible for the high antioxidant capacity of the tumor cells thus making them resistant to chemo- and radiotherapies
  • The reliance on glucose and glutamine for tumor cell malignancy comes largely from the documented defects in the number, structure, and function of mitochondria and mitochondrial-associated membranes
  • These abnormalities cause the neoplastic GBM cells to rely more heavily on substrate level phosphorylation than on oxidative phosphorylation for energy
  • dexamethasone not only increases blood glucose levels but also increases glutamine levels through its induction of glutamine synthetase activity
    • Nathan Goodyear
      Nathan Goodyear on 21 May 18
       
      use mannitol instead
  • Calorie restriction and restricted KD are anti-angiogenic, anti-inflammatory, anti-invasive, and also kill tumor cells through a proapoptotic mechanism
  • Evidence also shows that therapeutic ketosis can act synergistically with several drugs and procedures to enhance cancer management improving both progression free and overall survival
  • hyperbaric oxygen therapy (HBOT) increases oxidative stress on tumor cells especially when used alongside therapies that reduce blood glucose and raise blood ketones
  • The glutamine dehydrogenase inhibitor, epigallocatechin gallate (EGCG) is also proposed to target glutamine metabolism
  • Nathan Goodyear on 01 Apr 18
     
    Case study of Glioblastoma treated with ketogenic metabolic therapy as an adjuct to modified standard therapy.
Nathan Goodyear

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer | Nutrition & Metabolism | Full Text - 0 views

nutritionandmetabolism.biomedcentral.com/...s12986-015-0009-2

cancer GKI glucose ketone index ketogenic diet nutrition

shared by Nathan Goodyear on 02 Apr 18 - No Cached
  • The ‘Glucose Ketone Index’ (GKI) was created to track the zone of metabolic management for brain tumor management
  • The GKI is a biomarker that refers to the molar ratio of circulating glucose over β-OHB, which is the major circulating ketone body.
  • We present evidence showing that the GKI can predict success for brain cancer management in humans and mice using metabolic therapies that lower blood glucose and elevate blood ketone levels
  • ...14 more annotations...
  • The GKI can be useful in determining the success of dietary therapies that shift glucose- and lactate-based metabolism to ketone-based metabolism
  • Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, chronic inflammatory disease, and epilepsy
  • The zone of metabolic management is likely entered with GKI values between 1 and 2 for humans
  • Optimal management is predicted for values approaching 1.0, and blood glucose and ketone values should be measured 2–3 hours postprandial, twice a day if possible
    • Nathan Goodyear
      Nathan Goodyear on 09 May 18
       
      check GKI 2-3 hr postprandial twice daily
  • Preclinical studies have demonstrated a clear linkage between GKI and therapeutic efficacy
  • the Warburg effect (aerobic fermentation of glucose) is a common metabolic malady expressed in nearly all neoplastic cells of these and other malignant tumors
  • Aerobic fermentation (Warburg effect) is necessary to compensate for the insufficiency of mitochondrial oxidative phosphorylation in the cells of most tumors
  • Normal brain cells gradually transition from the metabolism of glucose to the metabolism of ketone bodies (primarily β-hydroxybutyrate and acetoacetate) for energy when circulating glucose levels become limiting
  • Ketone bodies bypass the glycolytic pathway in the cytoplasm and are metabolized directly to acetyl CoA in the mitochondria
  • Tumor cells are less capable than normal cells in metabolizing ketone bodies for energy due to their mitochondrial defects
  • daily activities and emotional stress can cause blood glucose levels to vary making it difficult for some people to enter the predicted zone of metabolic management
  • a clear association of the GKI to the therapeutic action of calorie restriction against distal invasion, proliferation, and angiogenesis in the VM-M3 model of glioblastoma
  • The results suggest that GKI levels that approach 1.0 are therapeutic for managing brain tumor growth
  • Therapeutic efficacy of the KD or calorie restriction is greater with lower GKI values than with higher values
  • Nathan Goodyear on 02 Apr 18
     
    The glucose ketone index shown to predict dietary metabolic success. In humans with brain cancer-- the target is 1.  The glucose and ketone (betahydroxybutyrate) should be measured 2-3 hours postprandial twice daily.
Nathan Goodyear

The Effect of a Vegetarian vs Conventional Hypocaloric Diabetic Diet on Thigh Adipose Tissue Distribution in Subjects with Type 2 Diabetes: A Randomized Study: Journal of the American College of Nutrition: Vol 0, No 0 - 0 views

www.tandfonline.com/...07315724.2017.1302367

vegetarian diabetes fat nutrition

shared by Nathan Goodyear on 26 Jun 17 - No Cached
  • Nathan Goodyear on 26 Jun 17
     
    Vegetarian diet out performs low calorie diet by reducing more muscle fat.
Nathan Goodyear

JPM | Free Full-Text | Accuracy in Wrist-Worn, Sensor-Based Measurements of Heart Rate and Energy Expenditure in a Diverse Cohort - 0 views

www.mdpi.com/3

exercise fitness trackers

shared by Nathan Goodyear on 30 May 17 - No Cached
  • Nathan Goodyear on 30 May 17
     
    fitness trackers not reliable at all in the measure of calories burned.
fnfdoc

Popular Diet Plans: Suitable Diet Plan For Me? - Health Blog - 0 views

fnfdoc.com/healthy-weight-loss-diet-plans

Diet Plans GM Diet Plan Military Diet Plan 1200 Calories Diet Plan Keto Diet Plan DASH Diet Plan General Motor Diet Plan 3-Day Diet Plan Weight Loss Diet Plans Calorie Losing Plan Health Blog Health

shared by fnfdoc on 09 Sep 20 - No Cached
  • fnfdoc on 09 Sep 20
     
    Which diet plan is suitable for me? Its not anymore unanswered. Keto diet is one of the popular diet plans these days. Diet plans for healthy weight loss
Nathan Goodyear

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers - 0 views

www.ncbi.nlm.nih.gov/...PMC7214421

plant-based diet fasting vitamin C nutrition

shared by Nathan Goodyear on 19 May 20 - No Cached
  • Nathan Goodyear on 19 May 20
     
    vitamin C + calorie-restricted plant-based diet found to inhibit KRAS colorectal cancer cell growth in mouse model.
redleafteadotcom

Starter Matcha The Perfect Tea - 2 views

This Starter Matcha Green Tea Powder is organic and culinary grade. It has been proven time and again to be a calorie-burning booster that increases or aids in maintaining a healthy metabolism as ...

foods health tea green powder

started by redleafteadotcom on 23 Apr 16 no follow-up yet
Nathan Goodyear

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men - 0 views

www.ncbi.nlm.nih.gov/...PMC4918028

GELDING theory GELDING LPS gut gut health inflammation low T low Testosterone Testosterone hypogonadism obesity

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function)
  • trans-mucosal passage of bacterial lipopolysaccharide (LPS) from the gut lumen into the circulation is a key inflammatory trigger underlying male hypogonadism
  • Obesity and a high fat/high calorie diet are both reported to result in changes to gut bacteria and intestinal wall permeability, leading to the passage of bacterial endotoxin (lipopolysaccharide- LPS) from within the gut lumen into the circulation (metabolic endotoxaemia), where it initiates systemic inflammation.
  • ...1 more annotation...
  • Endotoxin is known to reduce testosterone production by the testis, both by direct inhibition of Leydig cell steroidogenic pathways and indirectly by reducing pituitary LH drive, thereby also leading to a decline in sperm production.
  • Nathan Goodyear on 30 Jun 16
     
    Ever heard of the GELDING theory?  This involves the link between LPS endotoxin from the gut and low Testosterone in obese men.
Nathan Goodyear

Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women: Randomized Controlled Trial - 0 views

jco.ascopubs.org/...JCO.2011.37.9792.abstract

obesity obese overweight weight-loss aromatase breast cancer testosterone estradiol estrogen hormones women

shared by Nathan Goodyear on 22 May 12 - No Cached
  • Nathan Goodyear on 22 May 12
     
    Not surprising, but nice to see in study.  Dr. McTiernan showed that weight loss as little as 5% reduces breast cancer risk.  The reason?  Decreased Testosterone production in women due to insulin resistance and decreased fat for aromatase conversion of Testosterone to Estradiol and decreased androstenedione to estrone.  This study confirms the importance of the obesity epidemic to health.
Nathan Goodyear

ScienceDirect.com - Nutrition - Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet - 0 views

www.sciencedirect.com/...S0899900712000809

vitamin C vitamin C fatigue athlete athletic performance heart rate obesity overweight exercise

shared by Nathan Goodyear on 12 Jul 12 - No Cached
  • Nathan Goodyear on 12 Jul 12
     
    A very small study, but vitamin C shown to reduce fatigue, perception of fatigue and reduced heart rate.  This has implications in improving athletic performance.  The question, what does high dose vitamin C due for fatigue, heart rate, and athletic performance.
Nathan Goodyear

Nutrition Journal | Full text | Micronutrient deficiency in obese subjects undergoing low calorie diet - 0 views

www.nutritionj.com/...34

micronutrient deficiencies obesity.

shared by Nathan Goodyear on 31 Aug 12 - No Cached
  • Nathan Goodyear on 31 Aug 12
     
    micronutrient deficiencies found to be common in obese individuals.  And it stands to reason, that amino acid (protein) shakes do nothing to correct this.
Nathan Goodyear

FDA says HCG weight-loss products are illegal - - CNN.com Blogs - 0 views

thechart.blogs.cnn.com/...-weight-loss-drugs-are-illegal

FDA HCG natural calorie-restriction

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    I agree with the fact that studies have not shown HCG helps with weight loss in addition to the 500 cal diet. We have many studies in diigo supporting this.  However, the FDA is stepping out of its authorized scope.  
Nathan Goodyear

http://care.diabetesjournals.org/content/early/2013/02/07/dc12-1912.full.pdf - 0 views

care.diabetesjournals.org/...dc12-1912.full.pdf

protein carbohydrates macronutrients insulin resistance obesity obese inflammation inflammatory cytokines premenopause women

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Study finds that higher protein to carbohydrate intake has a positive effect on inflammatory cytokines, oxidative stress, improves insulin sensitivity and improves Beta cell function in premenopausal, non diabetic obese women.
Nathan Goodyear

Kent Holtorf: Long Term Weight Loss - More Than Will Power? - 0 views

www.huffingtonpost.com/...-weight-loss---m_b_192933.html

leptin reverse T3 weight loss

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • f greater than 10, it demonstrates there is a degree of leptin resistance contributing to an inability to lose weight
  • that it is difficult to lose weight with leptin resistance. High carbohydrate diets and in particular high-fructose corn syrup is shown to significantly increase leptin resistance and is a likely mechanism that high fructose corn syrup is associated with obesity
  • ...9 more annotations...
  • inactive thyroid hormone called thyroxine
  • it is problem inside the cell that the inactive T4 is not converted to T3 but rather to a mirror image of T3 called reverse T3. The reverse T3 has the opposite effect of T3, blocking the effects of T3 and lowering rather than increasing metabolism.
  • Studies are showing that stress and dieting (especially yo-yo dieting) can set this hormone into action as well as chronic illness such as diabetes, chronic fatigue syndrome and fibromyalgia.
  • As soon as the body senses a reduction in calories, the production of reverse T3 is stimulated to lower metabolism
  • With chronic dieting or stress, the body often stays in this "starvation mode" with elevated levels of reverse T3 and decreased levels of T3, which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • Studies are showing that such standard testing will miss 80% of thyroid dysfunction
  • ree T3/reverse T3 ratio
  • Nathan Goodyear on 09 Mar 11
     
    Fantastic review by Dr. Holtorf on reverse T3, leptin, and weight loss
Nathan Goodyear

Arch Intern Med -- Abstract: Human Chorionic Gonadotropin (HCG) Treatment of Obesity, February 1977, Shetty and Kalkhoff 137 (2): 151 - 0 views

archinte.ama-assn.org/...151

HCG weight loss obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • hese results indicate that HCG has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss.
  • Nathan Goodyear on 21 Apr 11
     
    HCG injections appear to have no effect on weight loss over those following 500 cal diets
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