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Benefits of progesterone, are in part, due to its function on the immune system.  Progesterone shown to decrease T cell activity, macrophage activity and NK cell activity.  Aside, NK cell activity has been found to be increased in those with recurrent first trimester miscarriages and progesterone defects.  So, low progesterone allows for a rise in NK cell activity and inflammation that is detrimental to a developing pregnancy.  If that is the case in pregnancy, what about the rest of the body?

Vitamin D inhibits inflammatory signaling through the LPS stimulated macrophages through the up regulation of MKP-1.

good discussion on how adipose tissue recruits macrophages and increases inflammatory signaling initiating insulin resistance.  This reveals how adipose tissue is extremely active.

large case study of Autoimmune Syndrome Induced by Adjuvants; also known as ASIA.  Think of Aluminum as the perfect example and think of macrophages myofasciitis.

Adjuvants in vaccines are dangerous.  ASIA and macrophages myofasciitis are implicated in the damage caused by adjuvants, of which aluminum is the most widely known.  I love what the author says here: "safe assessments for vaccines have often not included appropriate toxicity studies because vaccines have not been viewed as inherently toxic".  This is not political but scientific.

Aluminum as an adjuvant in vaccines is associated with macrophages myofasciitis and ASIA.

cordyceps shown to decrease LPS stimulated macrophage inflammation.  Specifically, IL-1Beta, IL-6, TNF-alpha were shown to be inhibited.  Also, NF-kappaB inhibition was found with cordyceps

ATMs and obesity induced inflammation initiates insulin resistance and thus type II diabetes. The bodies reaction to a fat cell is no different than a bacterial, viral, or parasitic infection.  The body recognizes something (fat) that shouldn't be there and it attempts to destroy it and remove it.

Study finds that Testosterone provided a small anti-inflammatory effect in post-menopausal women and men, whereas Estrogen increased macrophage cytokine production in post-menopausal women with elevated LDL.  Now, this study did not differentiate PCOS versus non-PCOS, nor did it look at the effects of adiposity in these hormonal effects in women.  Both of which, will effect the outcome.

Absolute must read!  Science. That is what physicians are.  Eliminate politics and bias.  Aluminum, common adjuvant in vaccines and well known neurotoxin, has been linked to post vaccine macrophagic myofascitis.  Now, world experts have placed it at the forefront of a new created syndrome "ASIA" which is autoimmune/inflammatory syndrome induced by adjuvants.  

Author states that there may be a link between vaccine adjuvants and post-vaccine myopathies as in macrophagic myofasciitis.  He concludes with "the concept of a possible causal link between immunization and inflammatory myopathies should not be totally rejected".  Not associated, but causal.

Study points to obesity and low Testosterone contribution of neuroinflammation.  No effect of body weight was seen with TRT.  This animal model found similar positive effects of TRT in insulin sensitivity.  Obesity and low T increase inflammatory cytokine production: this study found an increase in TNF-alpha and IL-1beta and TRT reduced TNF-alpha and IL-1beta to near base-line.  Testosterone is neuroprotective and this study reviewed the small volume of evaded that pointed to benefit from estradiol.  Testosterone's effect on glial survival was positive but not significant.  Obesity and low T were found to be associated with increased macrophage infiltration in the PNS with increased TNF-alpha and IL-1beta.   Testosterone therapy improved peripheral neuropathy via its positive effects on nocicieption.

hypercalcemia in cancer and treatments.

macrophages

Orally administered Germanium, at 300 mg/kg) found to increase NK activity and activation of macrophages via Interferon in mouse animal model.

To be read

Vitamin C inhibits M2 macrophages in the TME and inhibits EMT.