Skip to main content

Home/ Dr. Goodyear/ Group items matching ""IV vitamin c"" in title, tags, annotations or url

Group items matching
in title, tags, annotations or url

Sort By: Relevance | Date Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164

sepsis IV vitamin C vitamin C CRP

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
  • ...7 more annotations...
  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.ncbi.nlm.nih.gov/...PMC1405876

IV vitamin C vitamin C cancer

shared by Nathan Goodyear on 24 Apr 17 - No Cached
  • peak plasma concentrations obtained intravenously are estimated to reach 14 000 μmol/L, and concentrations above 2000 μmol/L may persist for several hours
  • Emerging in vitro data show that extracellular ascorbic acid selectively kills some cancer but no normal cells by generating hydrogen peroxide
  • Death is mediated exclusively by extracellular ascorbate, at pharmacologic concentrations that can be achieved only by intravenous administration
  • ...6 more annotations...
  • Vitamin C may serve as a pro-drug for hydrogen peroxide delivery to extravascular tissues, but without the presence of hydrogen peroxide in blood
  • not all cancer cells were killed by ascorbic acid in vitro
  • Intravascular hemolysis was reported after massive vitamin C administration in people with glucose-6-phosphate dehydrogenase deficiency
  • Administration of high-dose vitamin C to patients with systemic iron overload may increase iron absorption and represents a contraindication
  • Ascorbic acid is metabolized to oxalate, and 2 cases of acute oxalate nephropathy were reported in patients with pre-existing renal insufficiency given massive intravenous doses of vitamin C
  • Rare cases of acute tumour hemorrhage and necrosis were reported in patients with advanced cancer within a few days of starting high-dose intravenous vitamin C therapy, although this was not independently verified by pathologic review
  • Nathan Goodyear on 24 Apr 17
     
    IV vitamin C associated with prolonged survival in 3 patients with different cancers.  Peak serum levels reached 14,000 micromol/L, which levels above the 1,000 micro mol/L (cancer cell cytotoxic threshold) were maintained for hours
Nathan Goodyear

Effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis - 0 views

www.riordanclinic.org/...MRI-v01n02-p26.pdf

RA rheumatoid arthritis rheumatoid arthritis IV vitamin C intravenous IV vitamin C ascorbic vitamin C inflammation autoimmune

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    This study, small pilot, showed that they were able to lower inflammation in those suffering from RA, through high dose vitamin C IV therapy. This study stopped at 25 gms. The vitamin C is a scavenger of ROS and ROS stimulates inflammation through NF-kappaB. This is how vitamin C can reduce inflammation.
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues - 0 views

www.ncbi.nlm.nih.gov/...PMC1224653

IV vitamin C vitamin C intravenous alternative Intravenous vitamin C vitamin C cancer H2O2 ascorbic acid

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C and IV vitamin C only can deliver levels to tumor cells that induce formation of H2O2 that then induces cell death.
Nathan Goodyear

The Beneficial Effects of Antioxidant Supplementation in Enteral Feeding in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial - 0 views

www.anesthesia-analgesia.org/...857.long

IV intravenous vitamin C E critically ill sepsis antioxidant therapy treatment

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    IV vitamin C and vitamin E was found to lower the mortality rate in those with critical illness at the 28 day mark.  This study showed the safety and efficacy of IV vitamin C and vitamin E in those critically ill.
Nathan Goodyear

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/26350063

NAC vitamin C high dose vitamin C high-dose vitamin C NAD cancer IV vitamin C high-dose IV vitamin C High dose IV vitamin C

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    NAD and NAC counter the effects of vitamin C IN CANCER
Nathan Goodyear

Intravenous administration of vitamin C in the... [Med Sci Monit. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20424557

IV IV therapy IV vitamin C nutritional therapy vitamin C herpetic neuralgia vitamins vitamin vitamin therapy

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    Two case studies that show IV vitamin C aided in the resolution of herpetic neuralgia.
Nathan Goodyear

Septic impairment of capillary blood flow requires NADPH oxidase but not NOS and is rapidly reversed by ascorbate through an eNOS-dependent mechanism - 0 views

www.ncbi.nlm.nih.gov/...PMC2572871

IV intravenous vitamin C BH4 tetrahydrobiopterine sepsis ascorbic acid

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    IV vitamin C and BH4 shown to resolve blood flow restriction in Sepsis rat model.  Again, revealing the benefits of not only vitamin C, but IV vitamin C.
Nathan Goodyear

High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy - 0 views

stm.sciencemag.org/...222ra18

ovarian cancer IV vitamin C vitamin C intravenous vitamin C

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    IV vitamin C shown to augment cancer killer effect of chemotherapy.  This study looked at ovarian cancer in animal models and in humans.  The effect--a synergistic effect was found that promoted tumor destruction.  The great thing about IV vitamin C is the benefit but also the very low side effect profile.
Nathan Goodyear

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use - 0 views

www.annals.org/...533.short

IV intravenous vitamin C therapy treatment minerals vitamins

shared by Nathan Goodyear on 22 Nov 11 - No Cached
  • Nathan Goodyear on 22 Nov 11
     
    only high dose IV vitamin C shown to produce high plasma vitamin C concentrations compared to oral vitamin c.
Nathan Goodyear

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany - 0 views

iv.iiarjournals.org/...983.abstract

vitamin C IV intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IV vitamin C shown to improve quality of life measures in breast cancer patients during chemo/radiation.  What this shows, is that IV vitamin C is not only safe for healthy individuals, but healthy for cancer patients.
Nathan Goodyear

Effect of intravenous ascorbic acid in hemod... [Am J Kidney Dis. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16564942

IV vitamin C IV vitamin C antioxidant antioxidants anemia

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    High dose IV vitamin C shown to be well tolerated in those on hemodialysis.  Liver enzymes were followed throughout the course of the 6 month trial.  In fact, IV vitamin C was shown to improve the response of the EPO therapy.
Nathan Goodyear

Altered Deoxyribonuclease Activity in Cancer Cells and its Role in Non Toxic Adjuvant Cancer Therapy with Mixed Vitamins C and K3 - 0 views

ar.iiarjournals.org/...2727.full.pdf+html

autoschizis cancer IV vitamin C IV vitamin K3 vitamin C vitamin K3 vitamin C K K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    Combination of IV vitamin C and K3 in ratio of 100:1 shown to provide mechanism to induce cancer cell death through a process called autoschizis.
Nathan Goodyear

The association of vitamins C and K3 kills ca... [Eur J Med Chem. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12767595

IV vitamin C IV vitamin K3 vitamin C K K3 vitamin C vitamin K3 cancer autoschizis

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin C and K3 show synergistic cancer cell death via autoschizis.
Nathan Goodyear

Massive Doses of Vitamin C and the Virus Diseases - 0 views

www.seanet.com/...med_surg-1951-v103-n4-p101.htm

IV therapy IV C virus viral illness nutrition nutritional therapy

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    High dose IV vitamin C beneficial in viral illnesses.  This is a case study article, but it discusses how viral illnesses are associated with low vitamin C levels and how high dose vitamin C therapy benefits the immune activity against viral invaders.
Nathan Goodyear

Plasma vitamin C is lower in postherpetic neural... [Clin J Pain. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19692796

IV IV therapy IV vitamin C vitamin C vitamin vitamins nutritional therapy pain post-herpetic neuralgia

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    IV vitamin C aids pain control in postherpetic neuralgia.
Nathan Goodyear

The in vitro antitumor activity of vi... [Anticancer Res. 2003 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12926064

IV vitamin C IV vitamin K3 vitamin C vitamin K3 IV vitamin C K K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin C and K3 show synergistic activity against ovarian cancer.  
Nathan Goodyear

False Positive finger stick blood glucose readings after high-dose intravenous vitamin C - 0 views

www.riordanclinic.org/...89024578.pdf

IV vitamin C vitamin C glucose vitamin C

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    IV vitamin C > 15 grams falsely elevates finger sticks on glucose. Glucose and vitamin C are very similar chemically. This, however, is a false reading.
Nathan Goodyear

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer - 0 views

bmccancer.biomedcentral.com/...s12885-019-5696-z

IV vitamin C cancer vitamin C

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Phase I study of vitamin C and FOLFOX or FOLFIRI. Numerous studies have shown the extremely high safety profile of IV vitamin C in cancer. The need to show the same thing time and time again borders on the insanity. The potential adverse events listed in this study is from the FOLFOX or FOLFIRI, not the vitamin C.
Nathan Goodyear

Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/29432735

IV vitamin C CSC High dose IV vitamin C cancer stem cells vitamin C high dose vitamin C high-dose IV vitamin C cancer

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    High dose vitamin C preferentially targets CSC but not differentiated cells.
‹ Previous 21 - 40 of 283 Next › Last »
Showing 20▼ items per page