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Nathan Goodyear

Mild Traumatic Brain Injury in UK Military Personnel Returni... : The Journal of Head T... - 0 views

journals.lww.com/...n_Injury_in_UK_Military.5.aspx

TBI traumatic traumatic brain injury military soldiers

shared by Nathan Goodyear on 28 Feb 12 - No Cached
  • Nathan Goodyear on 28 Feb 12
     
    Prevalence of mild Traumatic Brain Injury was found to be 9.5% in returning US soldiers.  This was associated with PTSD and Etoh abuse.
Nathan Goodyear

Acta Pharmacologica Sinica - The neuroprotective effects of progesterone on traumatic b... - 0 views

www.nature.com/...aps2013160a.html

progesterone brain injury traumatic brain injury TBI hormone hormones head trauma

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Good discussion and review of progesterone's role as neuroprotective in TBI.
Nathan Goodyear

Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma - Chy... - 0 views

onlinelibrary.wiley.com/...20C0683F07B011D946D0062.f04t01

BDNF TBI traumatic brain injury exercise

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    exercise aids repair after TBI through BDNF.
Nathan Goodyear

Dietary Curcumin Supplementation Counteracts Reduction in Levels of Molecules Involved ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2805661

curcumin TBI traumatic brain injury mitochondria tumeric

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    TBI leaves the mitochondria of the brain compromised.  The result is a compromise in the ability to produce energy leaving the brain limited in its ability to heal and or handle additional insults.  This animal study found curcumin able to provide preservation of the energy pathways post TBI.  This has implications on any neuro-insult, not just TBI
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.long

curcumin DHA TBI traumatic brain injury brain injury neuroinflammation BDNF brain derived neurotrophic factor brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
  • ...10 more annotations...
  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
  • Nathan Goodyear on 31 Aug 15
     
    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.full

BDNF curcumin DHA TBI concussion brain injury traumatic brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • strategies directed to preserve phospholipids in the plasma membrane such as the use of dietary docosahexaenoic acid (C22:6n-3; DHA)5 can have beneficial effects for post-TBI recovery
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain
  • The combination of curcumin and DHA had a trend of greater effects in BDNF (117% of CTL; Figure 1C) compared with DHA or curcumin alone.
  • ...8 more annotations...
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • There was a significant group effect on BDNF (F 4,25 = 5.229, P < .01 by ANOVA), and FPI reduced BDNF levels (50% of CTL, P < .01; Figure 1C), which was counteracted by DHA supplementation (90% of CTL, P < .05; Figure 1C). Curcumin also counteracted this reduction of BDNF
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction.
  • curcumin contributed to enhance the action of DHA, protecting against cognitive impairment, and these effects were associated with elevations in the BDNF receptor signaling
  • Our current results show that curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus.
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • The effects of the DHA diet and curcumin on cognitive enhancement were consistent with enhanced elevations in BDNF receptor signaling
  • effects of DHA and curcumin up to 2 weeks after TBI because this is the most critical period for the course of injury recovery because the brain is metabolically dysfunctional during this time
  • Nathan Goodyear on 30 Aug 15
     
    study that finds curcumin + DHA increased cognitive improvement after TBI within 2 weeks.  Good discussion of the proposed mechanism--increased BDNF.
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

journals.lww.com/...everse_T3_in_Critically.1.aspx

free reverse T3 thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
  • Nathan Goodyear on 08 Mar 11
     
    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Hypopituitarism After Multiple Concussions: A Retrospective Case Study in an Adolescent... - 0 views

www.ncbi.nlm.nih.gov/...PMC1978466

concussions concussion head trauma men male hypopituitarism hormone hormones

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    multiple concussions result in hypopituitarism in 14 year old young man.
Nathan Goodyear

Prevalence of chronic hypopituitarism after blast concussion -- Wilkinson et al. 27 (1)... - 1 views

www.fasebj.org/...935.3

PCS TBI head trauma traumatic brain injury post concussion syndrome concussion hormones pituitary

shared by Nathan Goodyear on 18 Jan 16 - No Cached
  • Nathan Goodyear on 18 Jan 16
     
    One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury.  This study highlights the potential pituitary dysfunction that can result from TBI.
Nathan Goodyear

Diminished brain resilience syndrome: A modern day neurological pathology of increased ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4093745

brain PCS post concussion syndrome TBI concussion

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Nathan Goodyear on 20 Feb 16
     
    concussions
wheelchairindia9

Tynor Rib Belt - 0 views

www.wheelchairindia.com/...Tynor-Rib-Belt

How to Effectively use a Rib Belt most common injuries to the chest rib cage is a protective organ flat chest bone called the sternum toning up abdominal muscles after surgery reduction of waist size compression belt to support

shared by wheelchairindia9 on 31 Mar 16 - No Cached
  • wheelchairindia9 on 31 Mar 16
     
    Tynor Rib Belt Rib belt is applied to the thoracic and upper abdominal region to compress and bind the rib cage during rib fractures and postoperative care, while allowing sufficient flexibility for comfortable breathing. Extra porous. With splinting pad. No buckling or rolling over. Controlled compression. Tynor Rib Belt Features Light weight and thin construction, does not peep through the clothes improves patient compliance. Extra porous webbing improves ventilation and comfort of the patient. Broad hook and loop tape panel offers better holding and size adjust ability. Optimal compression, tones up abdominal muscles following surgery, CS or delivery. Special nylon reeves prevent rolling over of belt. Tynor Rib Belt Measurements Measure circumference around the chest.
Nathan Goodyear

https://doctorsonly.co.il/wp-content/uploads/2013/07/08_Epigenetic-Transmission.pdf - 0 views

doctorsonly.co.il/...08_Epigenetic-Transmission.pdf

PTSD epigenetics transgenerational transmission of trauma transgenerational inheritance

shared by Nathan Goodyear on 09 Oct 17 - No Cached
  • Nathan Goodyear on 09 Oct 17
     
    Study suggest the PTSD from the holocaust can be epigenetically transmitted to the offspring of the survivors.
fnfdoc

Amnesia: Types, Symptoms And Causes | Health Blog - 0 views

fnfdoc.com/...amnesia-types-symptoms-causes

Amnesia Amnesia Symptoms Amnesia Causes Amnesia Types Is Amnesia Real Amnesia Memory Loss Retrograde Amnesia Anterograde Amnesia Psychological Trauma Memory Loss

shared by fnfdoc on 04 Jul 19 - No Cached
  • fnfdoc on 04 Jul 19
     
    Are you living your life in depression? If yes then there is a chance you can lose your memory. There are types, symptoms & causes of Amnesia / Memory loss
  • fnfdoc on 04 Jul 19
     
    Amnesia is commonly known as memory loss. The reason of memory loss can be an emotional or physiological disorder, drugs abusement or Brian injuries. The memory loss can be temporary or permanent but mostly refers to temporary memory loss.
Nathan Goodyear

The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture - 0 views

www.ncbi.nlm.nih.gov/...PMC2921747

flouroquinolones ciprofloxacin levoquin tendinitis tendinopathy Tendon rupture

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Achilles tendinitis or rupture is among the most serious side effects associated with FQ use
  • The large body of data provided by clinical reports, histopathological examination, and experimental studies provides cogent evidence supporting a direct link between FQ use and tendonitis/tendon rupture
  • Risk factors associated with FQ-induced tendon disorders include age greater than 60 years, corticosteroid therapy, renal failure, diabetes mellitus, and a history of musculoskeletal disorders
  • ...17 more annotations...
  • The average age of FQ-induced tendinopathy is 64 years, with a male-to-female ratio of 2:1, and a 27-percent incidence of bilateral involvement
  • Although more than 95 percent of cases of tendinitis/rupture secondary to FQ involve the Achilles tendon, other reported sites of tendon involvement include the quadriceps, peroneus brevis, and rotator cuff
  • FQs demonstrate a 3.8-fold greater risk for development of Achilles tendinitis/rupture
  • a large population-based case control analysis, patients treated with FQs exhibited a substantially increased risk of developing tendon disorders overall (1.7-fold), tendon rupture (1.3-fold), and ATR (4.1-fold)
  • patients taking FQs with concurrent exposure to corticosteroids were found to experience a compounding effect on the risk of tendon rupture, specifically a 46-fold greater predisposition
  • Some authors have recommended that patients with a history of Achilles tendinitis and advanced age should not be prescribed FQ antibiotics
  • Approximately 50 percent of patients will recover within 30 days, with 25 percent of patients having symptoms persistent for longer than two months
  • The mean latency period between the start of FQ treatment and occurrence of tendinopathy has been reported to be a few hours to months, with a median onset of 6 days
  • The exact pathophysiology of FQ-induced tendinopathy remains elusive
  • it is possible that FQs have a direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue
  • It has been theorized that FQs disproportionately affect human tendons that have a limited capacity for repair, such as in older patients or structural compromise (i.e., pre-existing tendinopathy or trauma)
  • histopathological findings are similar to those observed in overuse conditions in athletes
  • Treatment with a FQ should be discontinued and physical therapy initiated
  • treatment should include rest and decreasing the physical load on the tendon.
  • Approximately 85 percent of patients present in less than one month
  • Because rupture can occur even late in the course of treatment or after discontinuation of FQ use, patients receiving a FQ should be counseled to seek medical attention immediately if symptoms, such as redness, pain, swelling, and stiffness, develop
  • FQs should be used cautiously in patients with risk factors associated with tendinitis, such as advanced age, history of tendon rupture, corticosteroid use, and/or acute or chronic renal dysfunction
  • Nathan Goodyear on 02 Aug 17
     
    Great review of the link between flouroquinolones and Tendinitis and Tendon rupture.  Yes, there is a direct link.
Nathan Goodyear

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may i... - 0 views

www.ncbi.nlm.nih.gov/...PMC3680782

progesterone non-genomic signaling head progesterone metabolites TBI brain injury trauma allopregnanolone traumatic brain injury

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Progesterone and its metabolite allopregnanolone show promise in protecting the brain in TBI.
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