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Nathan Goodyear

SpringerLink - Neurotoxicity Research, Volume 15, Number 1 - 0 views

www.springerlink.com/...c8v25k2418440257

neurotoxicity Parkinson's disease Grape seed extract curcumin

shared by Nathan Goodyear on 13 May 11 - No Cached
  • myloid plaques and microgliosis in the brain of Alzheimer’s mice fed with GSE were also reduced by 49% and 70%, respectively
  • Curcumin also significantly reduced brain Aβ burden and microglia activation
  • polyphenol-rich GSE prevents the Aβ deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD.
  • Nathan Goodyear on 13 May 11
     
    Grape seed extract and curcumin shown to reduce amyloid plaques and reduce inflammation in the brain: promising treatment in Alzheimers disease
Nathan Goodyear

Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Met... - 0 views

aacrjournals.org/...Dehydrogenase-Is-Not-Essential

cancer glucose 6 phosphate dehydrogenase G6PD lung seeding

shared by Nathan Goodyear on 24 Jul 22 - No Cached
  • Nathan Goodyear on 24 Jul 22
     
    Interesting point here: G6PD involved in lung seeding.
Nathan Goodyear

Horse chestnut seed extract for chronic venous insufficiency - 0 views

www2.cochrane.org/...ab003230.html

extract horse chestnut varicose veins seed

shared by Nathan Goodyear on 24 Feb 11 - No Cached
  • Overall, the trials suggested an improvement in the symptoms of leg pain, oedema and pruritus
  • The evidence presented suggests that HCSE is an efficacious and safe short-term treatment for CVI
  • Nathan Goodyear on 24 Feb 11
     
    horse chestnut effective in reducing symptoms of varicose veins
Nathan Goodyear

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Agg... - 0 views

www.nature.com/srep34477

neurodegenerative disease amyloid alzheimer's disease Parkinson's disease gut gut flora gut microbiome gut microbiota gut-brain

shared by Nathan Goodyear on 06 Oct 16 - No Cached
  • Our work suggests that protein misfolding and immune activation in neurodegenerative disorders are triggered through cross-seeding by exposure to exogenous microbial amyloids in the nose, mouth and gut.
  • Streptococcus mutans, Staphlococcus aureus, Salmonella enterica, Mycobacterium tuberculosis and others
  • Gene homologs encoding curli were recently determined also in four phyla: Bacteroidetes, Proteobacteria, Firmicutes, and Thermodesulfobacteria
  • ...8 more annotations...
  • changes in the gut microbiota induced by antibiotics alter neuroinflammation and amyloid deposition in a mouse model of AD
  • Our data suggest that amyloid proteins in the microbiota are involved in the origination and maintenance of neurodegenerative disease.
  • exposure to bacteria producing a functional extracellular amyloid protein enhances aggregation of AS in brain neurons in aged rats and in muscle cells in nematodes
  • AS aggregates seed aggregation of tau
  • involvement of the vagus nerve in PD
  • microgliosis, astrogliosis and enhanced expression of IL-6, TLR2 and TNF in the brain following curli exposure suggest the occurrence of an enhanced local sterile inflammatory response to AS in the brain.
  • the immune system in both AD and PD have now been extensively established
  • TLR2 activation through exposure to bacterial amyloid is pathogenic
  • Nathan Goodyear on 06 Oct 16
     
    Gut bacteria may play crucial role in systemic inflammation that leads to Alzheimer's and Parkinson's disease.  These amyloid production bacteria trigger systemic inflammation that leads to microglia activation and amyloid in the brain.   More establishment of the gut-brain connection.  
Nathan Goodyear

Oncotarget | NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Id... - 0 views

www.oncotarget.com/index.php

vitamin C IV vitamin C cancer cancer stem cells milk thistle silymarin ascorbic acid bee propolis CAPE glycolytic inhibitor natural

shared by Nathan Goodyear on 08 Dec 17 - No Cached
  • Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs
  • Cancer stem-like cells (CSCs) are thought to be the root cause of chemotherapy-resistance and radio-resistance
  • ultimately leading to treatment failure in patients with advanced disease [1-3]. They have been directly implicated mechanistically in tumor recurrence and metastasis, resulting in poor patient survival
  • ...26 more annotations...
  • mitochondrial biogenesis may be a key driver of the CSC phenotype
  • Our results indicate that increased mitochondrial oxidative stress and high NADH levels are both key characteristics of the CSC metabolic phenotype
  • high levels of NAD(P)H auto-fluorescence are known to be a surrogate marker for mitochondrial “power”, high OXPHOS capacity and increased ATP production
  • CSCs may be strictly dependent on NAD(P)H to maintain their enhanced mitochondrial function
  • an intact NAD+ salvage pathway is strictly required for mammosphere formation, supporting our results using NAD(P)H auto-fluorescence, which enriched CSC activity by more than 5-fold.
  • Since glycolysis is especially critical for maintaining the TCA cycle, OXPHOS and overall mitochondrial function, we next assessed the effects of known glycolytic inhibitors
  • we show that two other natural products that function as effective glycolysis inhibitors, also inhibited mammosphere formation. More specifically, vitamin C (ascorbic acid), which induces oxidative stress and inhibits the activity of GAPDH (a key glycolytic enzyme) [17], also inhibited mammosphere formation, with an IC-50 of 1 mM (Figure 7B). Therefore, vitamin C was ~10 times more potent than 2-DG at targeting CSC propagation
  • silibinin (the major active constituent of silymarin, an extract of milk thistle seeds) [18], which specifically functions as an inhibitor of glucose uptake, blocked mammosphere formation, with an IC-50 between 200 and 400 µM
  • caffeic acid phenyl ester (CAPE), a key component of honey-bee propolis, has potent anti-cancer properties
  • Propolis has a strong history of medicinal use, dating back more than 2,000 years
  • Because of it aromatic ring structure (Figure 8), we speculated that CAPE might function as a potent inhibitor of oxidative mitochondrial metabolism
  • CAPE quantitatively inhibits the mitochondrial oxygen consumption rate (OCR) and, in turn, induces the onset of aerobic glycolysis (ECAR)
  • CAPE shows a clear selectivity for targeting CSCs and adherent cancer cells, relative to normal fibroblasts.
  • CAPE functions as a “natural” mitochondrial OXPHOS inhibitor, that preferentially targets the CSC sub-population. This could explain CAPE’s known anti-cancer properties
  • Our data directly shows that a small fraction of the total cell population, characterized by increased PGC1α activity, high mitochondrial ROS/H2O2 and high NADH levels, has the ability to survive and grow under anchorage-independent conditions, driving mammosphere formation
  • We highlight the utility of certain natural products, such as Silibinin, Vitamin C and CAPE, that could be used to therapeutically target CSCs. Silibinin is the major active component of silymarin, which is an extract prepared from milk thistle seeds.
  • high NADH is a property that is conserved between normal and cancerous stem cells
  • Previous studies have also shown that when non-CSCs and CSCs are both fed mitochondrial fuels (such as L-lactate or ketone bodies), that CSCs quantitatively produce more NADH in response to this stimulus
  • CSCs may be strictly dependent on NADH to maintain their enhanced mitochondrial function
  • The Noble Prize winner, Linus Pauling, was among the first to describe and clinically test the efficacy of Vitamin C, as a relatively non-toxic anti-cancer agent
  • Vitamin C has two mechanisms of action. First, it is a potent pro-oxidant, that actively depletes the reduced glutathione pool, leading to cellular oxidative stress and apoptosis in cancer cells. Moreover, it also behaves as an inhibitor of glycolysis, by targeting the activity of GAPDH, a key glycolytic enzyme.
  • Here, we show that Vitamin C can also be used to target the CSC population, as it is an inhibitor of energy metabolism that feeds into the mitochondrial TCA cycle and OXPHOS
  • Vitamin C may prove to be promising agent for new clinical trials, aimed at testing its ability to reduce CSC activity in cancer patients, as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression and metastasis
  • Interestingly, a breast cancer based clinical study has already shown that the use of Vitamin C, concurrent with or within 6 months of chemotherapy, significantly reduces both tumor recurrence and patient mortality
  • CAPE quantitatively reduces mitochondrial oxygen consumption (OCR), while inducing a reactive increase in glycolysis (ECAR). As such, it potently inhibits mammosphere formation with an IC-50 of ~2.5 µM. Similarly, it also significantly inhibits cell migration
  • we also demonstrate that 7 different inhibitors of key energetic pathways can be used to effectively block CSC propagation, including three natural products (silibinin, ascorbic acid and CAPE). Future studies will be necessary to test their potential for clinical benefit in cancer patients.
  • Nathan Goodyear on 08 Dec 17
     
    The future of cancer therapy is cancer stem cells.  Study finds that Vitamin C, silymarin, and bee propolis blocks mitochondrial energy pathways in cancer stem cells.  Vitamin C is a known glycolytic inhbitor. Vitamin C was found to inhibit glycolysis via GAPDH targeting to inhibit the energy pathways of the mitochondria in CSCs.  The authors propse that Vitamin C can be used as add on therapies for conventional therapies to specifically attack the CSCs and their contribution to recrurence, treatment resistance, and metastasis potential all in addition to the ability of vitamin C to reduce the side effects of chemotherapy.
Nathan Goodyear

T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chem... - 0 views

aacrjournals.org/...omote-Metastasis-by-Regulating

chemotherapy metastasis

shared by Nathan Goodyear on 04 Oct 22 - No Cached
  • Nathan Goodyear on 04 Oct 22
     
    "…chemotherapy-induced, host-mediated mechanism that promotes remodeling of the extracellular matrix (ECM), ultimately facilitating cancer cell seeding and metastasis."
Nathan Goodyear

Diet and Sex Hormone-Binding Globulin - 0 views

jcem.endojournals.org/...293.full

diet SHBG flax seed protein men

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    In men, flax intake is positively associated with SHBG; whereas protein intake is inversely associated with SHBG.
Nathan Goodyear

Effect of Nigella sativa seeds on the glycemic con... [Indian J Physiol Pharmacol. 2010... - 0 views

www.ncbi.nlm.nih.gov/...21675032

Nigella Sativa herb herbs spice diabetes DM

shared by Nathan Goodyear on 17 Aug 11 - No Cached
  • Nathan Goodyear on 17 Aug 11
     
    Nigella sativa, spice, shown to improve blood sugar control in Type II Diabetes
Nathan Goodyear

Dietary Fiber - 0 views

advances.nutrition.org/...151.full

dietary fiber

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • decreased risk of coronary heart disease with dietary fiber consumption
  • Good sources of dietary fiber include whole grains, legumes, vegetables, nuts and seeds, and fruits
  • most experts recommend that fiber should be obtained through the consumption of foods, because this form allows consumption of many micronutrients and bioactive compounds contained in high-fiber foods, which provide their own nutritional benefits.
  • ...2 more annotations...
  • increase in the consumption of foods containing fiber to reduce obesity, cardiovascular disease, type 2 diabetes, and some cancers.
  • One of the products of fermentation, butyrate, is able to regulate gene transcription through its actions as a histone deacetylase inhibitor, which affects cell proliferation, differentiation, and apoptosis of colon cells
  • Nathan Goodyear on 28 Apr 11
     
    Great short review on Fiber and health benefits
Nathan Goodyear

The Metastatic Niche: Adapting the Foreign Soil - 0 views

www.ncbi.nlm.nih.gov/...PMC3682494

metastasis cancer seed and soil pre-metastatic niche

shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Nathan Goodyear on 13 Apr 20
     
    to be read
Nathan Goodyear

Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi - 0 views

www.ncbi.nlm.nih.gov/...PMC5374554

epigenetics nutrition Genome nutrigenomics

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Plant miRNA miR168a was found to present in the sera of mammals including human and regulate human gene LDLRAP1
  • plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression emerged. Broccoli sourced miR159 was found in human sera and proved to inhibit breast cancer growth through targeting the gene TCF7
  • This miRNA, with same 6mer and 7mer-A1 target seed sequence as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes through miRTar
  • ...1 more annotation...
  • plant miRNAs present in human circulating system were proven to be able to target human genes
  • Nathan Goodyear on 11 Dec 17
     
    Plant microRNA found in human serum.  Previous studies have shown that these plant microRNA's can interact with the human genome.
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