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Nathan Goodyear

Bactericidal activities of plant essential oils an... [J Food Prot. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12380738

essential oils bactericidal activity antibacterial

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • Nathan Goodyear on 15 Apr 11
     
    essential oils have broad spectrum activity against pathogenic bacteria
Nathan Goodyear

Antimicrobial agents from plants: antibacterial ac... [J Appl Microbiol. 2000] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...10736000

antimicrobial agents essential oils

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • Nathan Goodyear on 15 Apr 11
     
    essential oils have many anti-bacterial properties
Nathan Goodyear

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human ... - 0 views

www.jbc.org/...21136.full

DIM I3C PSA AR androgen receptor prostate cancer men male hormone hormones androgen

shared by Nathan Goodyear on 05 Nov 14 - No Cached
  • Inhibition of Endogenous PSA Expression by DIM
  • DIM strongly inhibited DHT induction of androgen-responsive genes by more than 50%
  • antiandrogenic activity of DIM
  • ...8 more annotations...
  • DIM suppresses DHT-induced cell growth and PSA expression and exhibits no AR agonist activity
  • DIM has a strong affinity for both the mutant AR inLNCaP cells and for recombinant wild-type human AR
  • nuclear translocation and foci formation of DHT-bound AR are inhibited by DIM
  • Our investigation, leads to the conclusion that DIM is a strong, pure androgen antagonist.
  • The down-regulation of PSA by DIM
  • PSA has been reported to promote the proliferation, migration, and metastasis of prostate cancer cells through several mechanisms, including cleavage of insulin-like growth factor-binding protein-3 and degradation of extracellular matrix proteins fibronectin and laminin
  • PSA expression is regulated by the AR and is thought to function as a growth factor in LNCaP cells
  • down-regulation of PSA expression may be important in the antiproliferative effects of DIM in LNCaP cells
  • Nathan Goodyear on 05 Nov 14
     
    DIM, from cruciferous veggies often used to aid estrogen metabolism, is found to decrease PSA transcription and function as an androgen receptor antagonist in prostate cancer cell lines.
Green Hill Tea

Benefits of Black Currant Tea - 0 views

blog.greenhilltea.com/benefits-of-black-currant-tea

Black Tea Wellness Fitness

shared by Green Hill Tea on 27 Jan 15 - No Cached
  • Green Hill Tea on 27 Jan 15
     
    Ever imagined of having caffeine free tea? If you are looking for one, then certainly you will relish black currant tea. Black currant tea is a caffeine free herbal tea that is made from the leaves and fruits of black currant plant. This tea is a gorgeous looking beverage as it is dark purple in colour.
Nathan Goodyear

Unbound MEDLINE : Treatment of inflammation and edema with bromelain. A plant proteolyt... - 0 views

www.unboundmedicine.com/...roteolytic_enzyme_concentrate_

systemic enzymes enzymes bromelaine inflammation

shared by Nathan Goodyear on 07 Jan 16 - No Cached
  • Nathan Goodyear on 07 Jan 16
     
    bromelaine, enzyme, reduces inflammation.
Nathan Goodyear

Effectiveness of altering serum cholesterol levels without drugs - 0 views

www.ncbi.nlm.nih.gov/...PMC1312230

cholesterol lifestyle nutrition mediterranean diet exercise plant sterols fiber omega 3 omega-3

shared by Nathan Goodyear on 06 Apr 16 - No Cached
  • Nathan Goodyear on 06 Apr 16
     
    nice review of the evidence of lifestyle interventions and/or alternative therapies with cholesterol
Nathan Goodyear

Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblasti... - 0 views

www.sciencedirect.com/...S0304383508000475

mistletoe cancer leukemia NK NK cells

shared by Nathan Goodyear on 08 Jul 18 - No Cached
  • Nathan Goodyear on 08 Jul 18
     
    Mistletoe induces apoptosis of lymphoblastic leukemic cells in in vivo study. Other studies have pointed to the increase NK activity as the primary mechanism
Nathan Goodyear

Anticancer mechanisms of cannabinoids - 0 views

www.ncbi.nlm.nih.gov/...PMC4791144

THC cannabinoids cancer

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival
  • cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals
  • Cannabis sativa L. (marijuana)
  • ...41 more annotations...
  • of the approximately 108 cannabinoids produced by C. sativa, Δ9-tetrahydrocannabinol (thc) is the most relevant because of its high potency and abundance in plant preparations
  • Tetrahydrocannabinol exerts a wide variety of biologic effects by mimicking endogenous substances—the endocannabinoids anandamide3 and 2-arachidonoylglycerol4,5—that engage specific cell-surface cannabinoid receptors
  • the cb2 receptor was initially described to be present in the immune system6, but was more recently shown to also be expressed in cells from other origins
  • transient receptor potential cation channel subfamily V, member 1
  • orphan G protein–coupled receptor 55
  • Most of the effects produced by cannabinoids in the nervous system and in non-neural tissues rely on cb1 receptor activation
  • two major cannabinoid-specific receptors—cb1 and cb2
  • cardiovascular tone, energy metabolism, immunity, and reproduction
  • cannabinoids are well known to exert palliative effects in cancer patients
  • best-established use is the inhibition of chemotherapy-induced nausea and vomiting
  • thc and other cannabinoids exhibit antitumour effects in a wide array of animal models of cancer
  • cannabinoid receptors and their endogenous ligands are both generally upregulated in tumour tissue compared with non-tumour tissue
  • cb2 promotes her2 (human epidermal growth factor receptor 2) pro-oncogenic signalling in breast cancer
  • pharmacologic activation of cannabinoid receptors decreases tumour growth
  • endocannabinoid signalling can also have a tumour-suppressive role
  • pharmacologic stimulation of cb receptors is, in most cases, antitumourigenic. Nonetheless, a few reports have proposed a tumour-promoting effect of cannabinoids
  • most prevalent effect is the induction of cancer cell death by apoptosis and the inhibition of cancer cell proliferation
  • impair tumour angiogenesis and block invasion and metastasis
  • thc and other cannabinoids induce the apoptotic death of glioma cells by cb1- and cb2-dependent stimulation
  • Autophagy is primarily a cytoprotective mechanism, although its activation can also lead to cell death
  • autophagy is important for cannabinoid antineoplastic activity
  • autophagy is upstream of apoptosis in the mechanism of cannabinoid-induced cell death
  • the effect of cannabinoids in hormone- dependent tumours might rely, at least in part, on the ability to interfere with the activation of growth factor receptors
  • glioma cells), pharmacologic blockade of either cb1 or cb2 prevents cannabinoid-induced cell death with similar efficacy
  • other types of cancer cells (pancreatic48, breast24, or hepatic43 carcinoma cells, for example), antagonists of cb2 but not of cb1 inhibit cannabinoid antitumour actions
  • thc promotes cancer cell death in a cb1- or cb2-dependent manner (or both) at lower concentrations
  • cannabidiol (cbd), a phytocannabinoid with a low affinity for cannabinoid receptors15, and other marijuana-derived cannabinoids57 have also been proposed to promote the apoptotic death of cancer cells acting independently of the cb1 and cb2 receptors
  • In cancer cells, cannabinoids block the activation of the vascular endothelial growth factor (vegf) pathway, an inducer of angiogenesi
  • In vascular endothelial cells, cannabinoid receptor activation inhibits proliferation and migration, and induces apoptosis
  • cb1 or cb2 receptor agonists (or both) reduce the formation of distant tumour masses in animal models of both induced and spontaneous metastasis, and inhibit adhesion, migration, and invasiveness of glioma64, breast65,66, lung67,68, and cervical68 cancer cells in culture
  • the ceramide/p8–regulated pathway plays a general role in the antitumour activity of cannabinoids targeting cb1 and cb2
  • cbd, by acting independently of the cb1 and cb2 receptors, produces a remarkable anti-tumour effect—including reduction of invasiveness and metastasis
  • cannabinoids can also enhance immune system–mediated tumour surveillance in some contexts
  • ability of thc to reduce inflammation75,76, an effect that might prevent certain types of cancer
  • recent observations suggest that the combined administration of cannabinoids with other anticancer drugs acts synergistically to reduce tumour growth
  • combined administration of gemcitabine (the benchmark agent for the treatment of pancreatic cancer) and various cannabinoid agonists synergistically reduced the viability of pancreatic cancer cells
  • Other reports indicated that anandamide and HU-210 might also enhance the anticancer activity of paclitaxel89 and 5-fluorouracil90 respectively
  • Combined administration of thc and cbd enhances the anticancer activity of thc and reduces the dose of thc needed to induce its tumour growth-inhibiting activity
  • Preclinical animal models have yielded data indicating that systemic (oral or intraperitoneal) administration of cannabinoids effectively decreases tumour growth
  • Combinations of cannabinoids with classical chemotherapeutic drugs such as the alkylating agent temozolomide (the benchmark agent for the management of glioblastoma80,84) have been shown to produce a strong anticancer action in animal models
  • pharmacologic inhibition of egfr, erk83, or akt enhances the cell-death-promoting action of thc in glioma cultures (unpublished observations by the authors), which suggests that targeting egfr and the akt and erk pathways could enhance the antitumour effect of cannabinoids
  • Nathan Goodyear on 18 Sep 18
     
    Good review of the anticancer effects of cananbinoids.
Nathan Goodyear

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma | Molecu... - 0 views

mct.aacrjournals.org/...90.long

cancer THC medical marijuana glioblastoma CBD

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Δ9-Tetrahydrocannabinol (THC; Supplementary Fig. 1), the main active component of the hemp plant Cannabis sativa
  • CB1, abundantly expressed in the brain and at many peripheral sites
  • CB2, expressed in the immune system and also present in some neuron subpopulations and glioma cells
  • ...3 more annotations...
  • antitumoral agents
  • Aside from THC, C. sativa produces approximately 70 other cannabinoids, although, unlike THC, many of them exhibit little affinity for CB receptors (10, 20). Of interest, at least one of these components, namely, cannabinol (CBD; Supplementary Fig. 1), has been shown to reduce the growth of different types of tumor xenografts including gliomas
  • the combined administration of THC and CBD is being therapeutically explored (10, 20, 26), although its effects on the proliferation and survival of cancer cells have only been analyzed in vitro
  • Nathan Goodyear on 18 Sep 18
     
    THC found to augment chemotherapy in the glioblastoma cell culture study.
Nathan Goodyear

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines - 0 views

file.scirp.org/...5-2500510_47691.htm

CBD medical marijuana THC prostate BPH male men VEGF hormone hormones cancer PSA CSC cancer stem cells

shared by Nathan Goodyear on 13 Feb 19 - No Cached
  • Nathan Goodyear on 13 Feb 19
     
    High CBD downregulates prostate CBD1, CBD2, chemosensitizes CSCs, suppressed cancer cell formation, down regulated IL-6 and IL-8, decreased PSA, and VEGF.
Nathan Goodyear

Mistletoe Plant Extract in Patients with Nonmuscle Invasive Bladder Cancer: Results of ... - 0 views

www.auajournals.org/...j.juro.2015.04.073

abnoviscum fraxinii mistletoe bladder cancer

shared by Nathan Goodyear on 11 Jun 21 - No Cached
  • Nathan Goodyear on 11 Jun 21
     
    Intra-vesicle bladder instillation of a. Fraxinii in bladder cancer
snehr09

Healthy Life Health | Write For Us - 0 views

www.healthylife.health/ts-of-avocado-you-need-to-know

healthy food diet plant-based and nutrition

shared by snehr09 on 27 Oct 21 - No Cached
  • snehr09 on 27 Oct 21
     
    Avocados are superfoods that fight cancer, provide protein and several vitamins to the body. They have abundant proportions of fiber, potassium, and good fats that promote weight loss. Read about the extraordinary benefits of including avocados in your daily diet.
Nathan Goodyear

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on ... - 0 views

jpet.aspetjournals.org/...1375.long

CBD cancer cannabidiol breast cancer cannabinoids

shared by Nathan Goodyear on 19 Oct 22 - No Cached
  • Nathan Goodyear on 19 Oct 22
     
    CBD tops CBG and CBC in anti-breast cancer effects.
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