Skip to main content

Home/ Dr. Goodyear/ Group items tagged outcomes

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Review: The Impacts of Circulating 25-Hydroxyvitamin D Levels on Cancer Patient Outcome... - 0 views

press.endocrine.org/...jc.2013-4320

cancer vitamin D vitamin D

shared by Nathan Goodyear on 09 Jul 14 - No Cached
  • Nathan Goodyear on 09 Jul 14
     
    meta-analysis, so take it for what it is worth; but higher vitamin D levels at the time of diagnosis were associate with better outcomes in those with cancer.  The improved outcomes included cancer mortality, disease-free survival, and overall survival.
Nathan Goodyear

JAMA Network | JAMA Surgery | Long-term Metabolic Effects of Laparoscopic Sleeve Gastre... - 0 views

archsurg.jamanetwork.com/article.aspx

obesity overweight bariatric surgery weight loss surgery

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Nathan Goodyear on 11 Aug 15
     
    This study reveals what is wrong with a lot of the "standard practice" and literature in medicine today.  At 5 years, almost 50% of weight loss with gastric sleeve is regained--defined as excess weight loss (only 50% weight loss of excess weight).  That is a terrible 5 year outcome; not to mention the definition of success.  Even at 3 years, 31% had regained their "excess weight".  Add to that, the numbers of patients that followed up was terrible.  This poor follow up points to worse data outcomes than this study claims.
Nathan Goodyear

Arch Surg -- Abstract: Long-term Outcomes of Laparoscopic Adjustable Gastric Banding, M... - 0 views

archsurg.ama-assn.org/...archsurg.2011.45v1

obesity obese overweight Gastric banding Lap

shared by Nathan Goodyear on 15 Apr 11 - No Cached
  • nearly 50% of the patients required removal of their bands (contributing to a reoperation rate of 60%), LAGB appears to result in relatively poor long-term outcomes.
  • Nathan Goodyear on 15 Apr 11
     
    Gastric Banding has poor long-term outcomes and results in 50% removal rate
Nathan Goodyear

Vitamin D and Acute Myeloid Leukemia | IntechOpen - 0 views

www.intechopen.com/...n-d-and-acute-myeloid-leukemia

cancer AML acute myeloid leukemia vitamin D leukemia

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Nathan Goodyear on 12 May 18
     
    low vitamin D associated with poor outcomes in hematologic cancers. This chapter reviews several studies that highlight the link with low vitamin D and poor outcomes in AML patients.
Nathan Goodyear

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors i... - 0 views

advances.sciencemag.org/...e1501924.full

progesterone PR progesterone receptors progesterone receptor cancer breast cancer hormones

shared by Nathan Goodyear on 29 Jun 16 - No Cached
  • The presence and activity of PR significantly affect the prognostic value of ER.
  • The observed loss of PR protein expression in a subset of ER+/PR+ breast cancers, because of hypermethylation or deletion of the PR gene locus, results in the loss of ER prognostic value
  • These findings emphasize the clinical value of assessing both PR and ER expression in breast cancer samples
  • ...7 more annotations...
  • PR is an essential modulator of ER-regulated genes but also that it significantly contributes to the prognostic value of ER in ER+/PR+ breast cancers
  • PR-regulated genes have independent prognostic value, and the presence of PR correlates with favorable clinicopathological outcomes
  • this study demonstrates that progestin-activated PR redirects ER chromatin binding and functions as a genomic estrogen agonist and as a phenotypic estrogen antagonist in ER+/PR+ breast cancer cells and human tumors
  • Approximately 80% of ER+ breast cancers are also positive for PR,
  • In isolation, both hormones activate or inhibit cellular processes in similar directions, although the magnitude of these effects is less for progestin alone than for estrogen alone
  • PR-mediated antagonism of estrogenic phenotypes is well documented
  • joint activation of ER and PR antagonized ER-regulated oncogenic processes
  • Nathan Goodyear on 29 Jun 16
     
    WOW!!  study finds that progesterone through PR activity antagonizes ER protein expression by the cell.  This has huge implications in breast cancer and possible prostate cancer.  But then again, women don't need progesterone; only estrogen.  The presence of PR correlates with improved clinicopathological outcomes.  The authors do seem to get confused about progesterone and progestins.  They are not one in the same.
Nathan Goodyear

Improved outcomes from the administrati - PubMed Mobile - 0 views

www.ncbi.nlm.nih.gov/...18447940

bioidentical hormone hormones progesterone TBI traumatic brain injury

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    bioidentical progesterone shown to improve outcomes for up to 6 months in those with traumatic brain injuries (TBI).  That is decreased mortality and less cognitive deficits
Nathan Goodyear

Statin use and risk of diabetes mellitus - 0 views

www.ncbi.nlm.nih.gov/...PMC4360430

statin statin therapy diabetes insulin resistance GLUT4 HgbA1c

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • An increase in new onset diabetes, i.e., 3% in statin arm and 2.4% in placebo arm was reported. This was accompanied by increase in median value of glycated haemoglobin and was one of the earlier studies to report the increase in new onset diabetes in patients on statins
  • Even after adjustment for potential confounders, statin therapy was associated with an increased risk of new-onset diabetes mellitus
  • Authors suggest that statin-induced diabetes mellitus is a medication class effect
  • ...10 more annotations...
  • Another study also reported that as compared to placebo, statin group showed a higher risk of physician reported incident diabetes and it was also observed that risk was higher in women as compared to men
  • Meta-analysis of randomized controlled trials by Sattar et al[25] involving 91140 non-diabetic patients showed that statin therapy was associated with 9% increased risk of incident diabetes
  • A number of studies showed dose dependent association between statin administration and incident diabetes
  • intensive dose of statins was associated with high incidence of new - onset diabetes
  • Treatment with atorvastatin and simvastatin may be associated with an increased risk of new onset diabetes as compared to pravastatin
  • Increased incidence of diabetes was seen with atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial
  • Increased insulin resistance secondary to statins was demonstrated in a prospective non randomised study in patients with coronary bypass surgery
  • downregulation of GLUT4
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
  • Nathan Goodyear on 04 Oct 17
     
    Great review article of the increased risk of worsening insulin resistance, glycated hemoglobin, and diabetes risk.  Atorvastatin appears to be the worst culprit.  Mechanism partially through a decrease in GLUT4.
Nathan Goodyear

18FDG-PET/CT for predicting the outcome in ER+/HER2- breast cancer patients: comparison... - 0 views

breast-cancer-research.biomedcentral.com/...s13058-016-0793-2

PET scan cancer breast cancer

shared by Nathan Goodyear on 19 Mar 18 - No Cached
  • our study confirms that baseline PET parameters measured before neoadjuvant treatment have prognostic values in ER+/HER2- locally advanced breast cancer patients
  • It has been suggested that high baseline 18F-fluorodeoxyglucose (18FDG) uptake assessed by high standardized uptake value (SUV) could be associated with poor prognostic factors such as the high histological grade [2] as well as worse survival
  • several teams observed that the change in SUV values early during neoadjuvant treatment could be a good indicator of pathological response and potentially outcome
  • ...5 more annotations...
  • others studies suggested that baseline 18FDG uptake, which would avoid performing a second examination, could also be of interest to predict patient outcome, especially in ER+/HER2- BC
  • ER+/HER2- BC has less intense 18FDG uptake than some other phenotypes such as TN carcinoma
  • Patients with high baseline 18FDG tumor uptake are at higher risk of early recurrence
  • The 3-year EFS was 78.4% in patients with baseline tumor SUVmax > 8.3 (vs. 94.0% in those with SUVmax ≤ 8.3)
  • event-free survival (EFS)
  • Nathan Goodyear on 19 Mar 18
     
    Study finds benefit of PET scan in prognosis in ER+/HER2- breast cancers.
Nathan Goodyear

Availability of evidence of benefits on overall survival and quality of life of cancer ... - 0 views

www.bmj.com/bmj.j4530

cancer cancer treatment survival quality of life

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Although the goal of cancer treatment is to improve the quantity and quality of life,123 clinical trials designed to gain regulatory approval for new drugs often evaluate indirect or “surrogate” measures of drug efficacy. These endpoints show that an agent has biological activity, but they are not reliable surrogates for improved survival4567891011 or quality of life46111213
  • two recent systematic reviews suggest that the strength of association between surrogates in cancer clinical trials and life extension is generally low
  • Available data from the US show that only a small proportion of cancer treatments approved by the US Food and Drug Administration (FDA) unequivocally show benefits on survival or quality of life.30
  • ...16 more annotations...
  • We sought to systematically evaluate the evidence base for all new drugs and new indications for the treatment of solid tumours and haematological malignancies approved by the EMA in the five year period 2009-13
  • Three investigators (AP, EP, and EG) independently extracted data on and descriptively analysed the following trial features: characteristics of the participant population, study design (randomisation, crossover from experimental to control group, and blinding of investigators and participants), experimental and control groups, enrolment, primary and secondary endpoints, magnitude of benefit on survival and quality of life, and narrative interpretation of the findings
  • Only 18 of the 68 (26%) were supported by a pivotal study powered to evaluate overall survival as the primary outcome
  • From 2009 to 2013, the EMA approved use of 48 oncology drugs
  • Seventeen drugs were approved for treatment of haematological malignancies and 51 for treatment of solid tumours
  • Overall, 72 clinical trials supported the approval of 68 novel drug uses
  • Our scoring was limited to drugs for solid tumours
  • Among 68 cancer drug indications approved by the EMA in the period 2009-13, and with a median of 5.4 years’ follow-up, only 35 (51%) were associated with a significant improvement in survival (26/35) or quality of life (9/35) over existing treatment options, placebo, or as add on treatment
  • Only two of the 26 drugs shown to extend life also showed benefits on quality of life
  • 33 (49%) had not shown any improvement on survival or quality of life
  • This systematic evaluation of oncology drug approvals by the EMA in 2009-13 shows that most of the drugs (39/68, 57%) entered the market without evidence of improved survival or quality of life
  • At a minimum 3.3 years after market entry, there was still no conclusive evidence that 33 of these 39 cancer drugs either extended or improved life
  • What are potential reasons for the paucity of drug approvals with demonstrable survival advantages over existing treatments?
  • Firstly, only 18 (26%) indications for use in our cohort were supported by trials in which extension of life was the primary outcome
  • None of the pivotal studies supporting oncology drug approvals from 2009 to 2013 included quality of life as a primary outcome measure
  • Most new oncology drugs authorised by the EMA in 2009-13 came onto the market without clear evidence that they improved the quality or quantity of patients’ lives
  • Nathan Goodyear on 20 Dec 17
     
    New study from European Medicines Agency questions alot of the new cancer drugs brought to the market 2009-2013.  57% of the new drugs (39/68) were brought to the market without evidence of improved survival or quality of life.
Nathan Goodyear

Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and ... - 0 views

www.ncbi.nlm.nih.gov/...27106765

CVD low T low testosterone estradiol Testosterone DHT dihydrotestosterone male health male hormones cardiovascular disease

shared by Nathan Goodyear on 26 Apr 16 - No Cached
  • Nathan Goodyear on 26 Apr 16
     
    study of middle aged men (mean age--50) finds no correlation between Testosterone, DHT, and higher Estradiol levels in CVD outcomes, including mortality.  Men who died during the study had lower total Testosterone, free Testosterone, and DHT levels than those that survived during the study.
Nathan Goodyear

Prognostic Influence of Increased Fibrinogen and C-Reactive Protein Levels in Unstable ... - 0 views

circ.ahajournals.org/...4204.full

fibrinogen CRP CAD coronary artery disease

shared by Nathan Goodyear on 28 Apr 12 - No Cached
  • Nathan Goodyear on 28 Apr 12
     
    fibrinogen and CRP associated with poor outcome in those individuals with CAD.
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.full

low T3 syndrome T4 TSH CVD cardiac hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    low T3, not T4 or TSH, found to be associated with a strong predictor of death in cardiac patients.  This also has implications in predicting outcome in cardiac patients.
Nathan Goodyear

Low vitamin C levels may raise heart failure patients' risk / American Heart Association - 0 views

newsroom.heart.org/...c-levels-may-raise-217754.aspx

vitamin C heart failure cardiovascular disease hs-CRP crp inflammation

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    patients with heart failure and low vitamin C levels have higher inflammation as measured by hs-CRP and elevated risk of worse outcomes
Nathan Goodyear

The Journal of Bone & Joint Surgery | Article - 0 views

jbjs.org/article.aspx

hyperglycemia surgery post-operative infection post operative infection

shared by Nathan Goodyear on 31 Jul 12 - No Cached
  • Nathan Goodyear on 31 Jul 12
     
    It is no surprise that hyperglycemia is associated with increased hospital stay and post operative infection.  I have seen this in my former population.  Especially in prolapse and incontinence surgeries (which I no longer perform).  However, what is interesting is that 1/3 of the non-diabetics are hyperglycemic.  The preparation of the individual has just as much to do with the successful outcome of the surgery as does the surgery itself.
Nathan Goodyear

Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

online.liebertpub.com/...jomh.2013.0016

Testosterone low T prostate cancer male men hormone hormones

shared by Nathan Goodyear on 25 Jan 14 - No Cached
  • Nathan Goodyear on 25 Jan 14
     
    Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).
Nathan Goodyear

Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo... - 0 views

jcem.endojournals.org/...3615.abstract

DHEA men hormone hormones

shared by Nathan Goodyear on 16 Sep 13 - No Cached
  • Nathan Goodyear on 16 Sep 13
     
    Meta-analysis finds DHEA beneficial in men.  The main outcome this study looked at was weight loss and/or body composition (i.e. muscle, fat...).
Nathan Goodyear

ARS | Publication request: Sex hormone modulation of proinflammatory cytokine and CRP e... - 0 views

www.ars.usda.gov/...publications.htm

hormone hormones inflammation Testosterone estrogen women LDL

shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    Study finds that Testosterone provided a small anti-inflammatory effect in post-menopausal women and men, whereas Estrogen increased macrophage cytokine production in post-menopausal women with elevated LDL.  Now, this study did not differentiate PCOS versus non-PCOS, nor did it look at the effects of adiposity in these hormonal effects in women.  Both of which, will effect the outcome.
Dr. Jennifer Martinick

Martinick Hair Restoration Clinic Offers World Class Facilities & Techniques - 0 views

www.pressreleasespider.com/feed142632.aspx

Dr Jennifer Martinick reviews Hair

shared by Dr. Jennifer Martinick on 27 Sep 13 - No Cached
  • Dr. Jennifer Martinick on 27 Sep 13
     
    Martinick Hair Restoration clinic is offering hygienic and world class facilities and techniques to deliver outstanding hair transplant results. The surgeons at the Martinick Hair Restoration clinics follow a multi-therapy approach to achieve the desired outcome.
Nathan Goodyear

Serum progesterone and prognosis in operable breast cancer. - 0 views

www.ncbi.nlm.nih.gov/...PMC2074551

progesterone breast cancer breast cancer survival

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    progesterone levels at the time of surgery predict outcome.  Higher progesterone levels associated with increased longevity.  progesterone > 4 ng/ml associated with 65% survival at 18 years versus 35% with those women and low progesterone.
Nathan Goodyear

High-dose vitamin D supplementation and measur... [Fertil Steril. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24636395

insulin sensitivity resistance vitamin D vitamin D PCOS

shared by Nathan Goodyear on 14 Apr 14 - No Cached
  • Nathan Goodyear on 14 Apr 14
     
    No significant statistical significance was found with vitamin D therapy and insulin sensitivity.  However, improved outcomes were found in 2 hour insulin and 2 hour glucose levels after a 75 gram OGTT.
1 - 20 of 162 Next › Last »
Showing 20▼ items per page