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Nathan Goodyear

Peptide-Based Treatment: A Promising Cancer Therapy - 0 views

www.hindawi.com/...761820

therapeutic peptides peptides Cancer

shared by Nathan Goodyear on 30 Oct 18 - No Cached
  • Nathan Goodyear on 30 Oct 18
     
    Peptide therapeutics review. Good review of evidence behind peptide therapies in specific cancers
Nathan Goodyear

Evaluation of the use of therapeutic peptides for cancer treatment | Journal of Biomedi... - 0 views

jbiomedsci.biomedcentral.com/...s12929-017-0328-x

therapeutic peptides peptides Cancer

shared by Nathan Goodyear on 25 Sep 18 - No Cached
  • Nathan Goodyear on 25 Sep 18
     
    Are peptides the future of cancer therapy?
Nathan Goodyear

Peptide-Based Treatment: A Promising Cancer Therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4629048

peptides peptide therapy cancer

shared by Nathan Goodyear on 04 Jul 20 - No Cached
  • Nathan Goodyear on 04 Jul 20
     
    Good review of peptides in diagnosis and some treatments of cancer
Nathan Goodyear

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of tri... - 0 views

journals.sagepub.com/...1535370213489492

peptide therapy cancer peptides TNBC breast cancer

shared by Nathan Goodyear on 05 Jul 20 - No Cached
  • Nathan Goodyear on 05 Jul 20
     
    Peptide therapy effective in inhibits proliferation in TNBC.
Nathan Goodyear

Glucagon-like peptide 1 improves the ability of th... [Diabetes. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9703326

glucagon-like peptid-1 insulin glucose control diabetes resistance

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • We concluded that low dosage GLP-1 improves the ability of the beta-cell to secrete insulin in both IGT and NIDDM subjects, but that the ability to sense and respond to subtle changes in plasma glucose is improved in IGT subjects, with only a variable response in NIDDM subjects. Beta-cell dysfunction was improved by GLP-1 infusion, suggesting that early GLP-1 therapy may preserve beta-cell function in subjects with IGT or mild NIDDM.
  • Nathan Goodyear on 06 Apr 11
     
    glucagon-like peptide-1 improves insulin/glucose regulation
Nathan Goodyear

Evaluation of the use of therapeutic peptides for cancer treatment - 0 views

www.ncbi.nlm.nih.gov/...PMC5359827

peptides therapeutic peptides peptide therapy cancer

shared by Nathan Goodyear on 22 Mar 21 - No Cached
  • Nathan Goodyear on 22 Mar 21
     
    To be read.
Nathan Goodyear

Incretin-based therapies: can we achieve glycemic control and cardioprotection? - 0 views

joe.endocrinology-journals.org/...T17.full

incretin incretins GLP-1 glucagon-like peptide 1) glucose homeostasis

shared by Nathan Goodyear on 24 Mar 14 - No Cached
  • Nathan Goodyear on 24 Mar 14
     
    Good discussion on the incretin: (Glucagon-like peptide 1 (GLP-1).
Nathan Goodyear

Opioid growth factor and the treatment of human pancreatic cancer: A review - 0 views

www.ncbi.nlm.nih.gov/...PMC3942827

peptides peptide therapy cancer

shared by Nathan Goodyear on 04 Jul 20 - No Cached
  • Nathan Goodyear on 04 Jul 20
     
    Review of Opioid Growth Factor inhibition of cancer growth via inhibition in cell cycle.
Nathan Goodyear

Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Wom... - 0 views

www.mdpi.com/...htm

probiotics alternative medicine natural medicine natural therapies diabetes gestational diabetes

shared by Nathan Goodyear on 15 May 17 - No Cached
  • The gut microbial composition is altered during pregnancy
  • probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
  • Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
  • ...5 more annotations...
  • probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
  • One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
  • Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
  • Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
  • LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
  • Nathan Goodyear on 15 May 17
     
    Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.
  • Open TeleShop on 17 May 17
     
    Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| www.openTeleshop.Com
Nathan Goodyear

The expanding role of incretin-based therapies: how much should we expect? - 0 views

joe.endocrinology-journals.org/...E1.full

incretins

shared by Nathan Goodyear on 08 Apr 14 - No Cached
  • The incretins are peptide hormones released from the small intestine during meal absorption that stimulate insulin secretion from pancreatic β-cells and reduce excessive secretion of glucagon by pancreatic α-cells
  • Nathan Goodyear on 08 Apr 14
     
    intro to incretins
Nathan Goodyear

Regulation of atrial natriuretic peptide, thr... [Chin Med Sci J. 1993] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8032065

Testosterone therapy men male hormone hormones TXA2 thromboxane A2 CHD

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    STudy finds that Testosterone reduced Thromboxane A2 production and improved the TXA2:PGI2 ratio.  This is in contrast to a '95 study that finds a increase in TXA2.  These men all had CHD.
Nathan Goodyear

Hyperthermia as an immunotherapy strategy for cancer - 1 views

www.ncbi.nlm.nih.gov/...PMC2828267

cancer hyperthermia

shared by Nathan Goodyear on 29 Nov 18 - No Cached
  • the notion of treating human cancers with heat dates back to the writings of Hippocrates
  • enhance the efficiency of standard cancer therapies, such as chemotherapy and radiation treatment
  • After antigen uptake at tumor sites, APCs have the ability to create a robust response by entering lymphoid compartments and programming lymphocytes
  • ...36 more annotations...
  • Hyperthermia differs fundamentally from fever in that it elevates the core body temperature without changing the physiological set point
  • hyperthermia is induced by increasing the heat load and/or inactivating heat dissipation
  • mor cells [2]. Although significant cell killing could be achieved by heating cells or tissues to temperatures > 42°C for 1 or more hours, the application, measurement and consistency of this temperature range within the setting of cancer clinical trials
  • mild temperature hyperthermia (ie, within the fever-range, 39–41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      101.2 to 105.8
  • moderate hyperthermia (41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      105.8 F
  • Hsps are a family of stress-induced proteins
  • they are key regulators of cellular protein activity, turnover and trafficking
  • Hsps ensure appropriate post-translational protein folding, and are able to refold denatured proteins, or mark irreversibly damaged proteins for destruction
  • the ability of fever-range hyperthermia to induce reactive immunity against tumor antigens through DCs and NK-cells is likely mediated by Hsps
  • thermotolerance
  • Hsps support the malignant phenotype of cancer cells by not only affecting the cells’ survival, but also participating in angiogenesis, invasion, metastasis and immortalization mechanisms
  • Hsps released from stressed or dying cells activate dendritic cells (DCs), transforming them into mature APCs
  • In theory, fever-range hyperthermia may take advantage of tumor cell Hsps by inducing their release from tumor cells and augmenting DC priming against tumor antigens
  • In several models of hyperthermia, heat-treated tumors exhibited improved DC priming and generation of systemic immunity to tumor cell
  • hyperthermia alone can enhance antigen display by tumor cells, thus rendering them even more susceptible to programmed immune clearance
  • Fever-range hyperthermia may also induce Hsps
  • Hsps may exert an adjuvant effect by bolstering MHC class II and co-stimulatory molecule expression by DCs
  • thermal ablation of liver tumors in particular has demonstrated an ability to potentiate immune responses [57, 58] and elicit robust T-cell infiltrates at ablation sites
  • specific Hsp, Hsp70, directly inhibits apoptosis pathways in cancer cells, as demonstrated in human pancreatic, prostate and gastric cancer cells
  • Cross-priming is the ability of extracellular Hsps complexed to tumor peptides to be internalized and presented in the context of MHC class I molecules on APCs, thus allowing potent priming of CTLs against tumor antigens
  • It has been reported that Hsps are generated from necrotic tumor cell lysates, but not from tumor cells undergoing apoptosis
  • tumor cells exposed to hyperthermia in the heat shock range (42°C for 4h) prior to lysing, DC activation and cross-priming were significantly enhanced with the application of heat
  • Due to the ability of Hsps to activate DCs directly by chaperoning tumor antigens upon their release [28], it is possible that both local and regional immune stimulation can be achieved with hyperthermia.
  • support the use of hyperthermia as an inducer of Hsps to serve as ‘danger signals’, activating antitumor immune responses
  • whole-body hyperthermia not only augments immune responses, but also stimulates the migration of skin-derived DCs to draining lymph nodes
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      This allows for the activation of lymphocytes by the activated dendritic cells.
  • suggest a valuable role of hyperthermia in DC cancer vaccine strategies
  • In mice treated with fever-range whole-body hyperthermia, tumor growth was significantly inhibited and NK-cell infiltration increased
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      Hyperthermia increased NK cell activation, proliferation, and infiltration, which equals increased cytotoxicity.
  • exposure to fever-range hyperthermia resulted in improved endogenous NK-cell cytotoxicity to several cancer types
  • improved activation and function of DCs and NK cells following hyperthermia
  • Hyperthermia increases the expression ICAM-1 a key adhesion molecule,
  • The combined effects of hyperthermia on lymphoid tissue endothelium and lymphocytes can promote immune surveillance and increase the probability of naive lymphocytes leaving the circulation and encountering their cognate antigen displayed by DCs in lymphoid organs.
  • In independent clinical studies, whole-body hyperthermia resulted in a transient decrease in circulating lymphocytes in patients with advanced cancer [12, 94, 99, 100], a finding which mirrored observations in animal models in which lymphocyte entry into lymph noeds was increased following hyperthermia treatment [93]. Enhanced recruitment of lymphocytes to lymphoid tissues may be exploited in the treatment of malignancies.
  • The initial tumor antigen presentation and initiation of clonal expansion of CTLs transpires in the lymph nodes and cannot take place outside this specialized compartment
  • the ability of DCs present in the lymph nodes to stimulate an anti-tumor immune response is critical
  • hyperthermia has been shown to improve immune surveillance by T-cell
  • and to increase DC trafficking to lymph nodes
  • Nathan Goodyear on 29 Nov 18
     
    Great review of hyperthermia.
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