methylmercury mediates neurotoxicity via mitochondrial damage, inflammation, and oxidative stress. Astrocytes accumulated the methyl mercury. The destruction of the astrocytes will result in an increase in glutamate. Methylmercury is synergistic with other toxins in the development of immunoexcitotoxicity.
Animal study finds that methyl Hg is not useful in determining effects of ethyl mercury. According to this study, the conclusion is that the ethyl Mercury from Thimerosal is converted to inorganic Hg as evident in the results. So, in essence, the ethyl mercury, considered less toxic than methyl mercury, is converted to inorganic Mercury a more toxic compound. The results of the study revealed a higher % of inorganic Hg in the brains of those exposed to thimerosal to those exposed to methylMercury.
low methylmercury shown to accumulate in the brains of monkeys in the form of inorganic mercury. Specifically, astrocytes and microglial cells accumulated the inorganic mercury. Long-term low exposure can result in neuro-accumulation of inorganic mercury and neurotoxicity.
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