The best marker associated with MetS in older men was low SHBG. Low T, DHT, and cFT were found to be more biomarkers of poor health rather than causal.
there appears to be a positive correlation between serum testosterone levels and insulin sensitivity in men across the full spectrum of glucose tolerance (Pitteloud et al, 2005), and this relationship is at least partially direct and not fully dependent on (changes in) elements of the MetS
supervised D&E alone led to significant improvements in testosterone concentrations, glycemic control, and components of the MetS
diet control, exercise, and testosterone supplementation may be beneficial in the management of men with T2D
androgen-deprivation therapy in males with prostatic cancer may be associated with an increased risk for T2D, which may be caused by negative effects on insulin sensitivity
insulin sensitivity, measured by HOMA, improved in both groups and with a significantly greater degree when testosterone was added to supervised D&E
Fasting insulin concentrations, a good representative of insulin sensitivity, did show a significant correlation with changes in circulating androgen levels, an observation in support of Pitteloud et al (2005), who showed a direct relationship between insulin sensitivity and circulating testosterone concentrations using the hyper-insulinemic euglycemic clamp technique
52 weeks of testosterone treatment also significantly improved circulation levels of adiponectin and hsCRP, key serum markers of insulin sensitivity and hepatic steatosis
The changes in both adiponectin and hsCRP were significantly correlated with the therapy-induced changes in bioavailable testosterone
a negative correlation was found between hsCRP levels and bioavailable testosterone
serum PSA concentrations did not differ between the 2 treatment groups, indicating that short-term testosterone administration appears to be acceptably safe
Study of men with metabolic syndrome and type II Diabetes finds that diet and exercise alone improved glucose control and metabolic syndrome components by 31%. The addition of Testosterone therapy increased this % to 81%.
Association of low TT, SHBG, and free Testosterone with MetS was found in this study on men. The association was influenced by BMI i.e. the overweight were found to have a higher association than the normal BMI.
Testosterone plays an important role in glucose and lipid metabolism. Thus, low Testosterone, will result in increased disruption in the homeostasis of glucose and lipids resulting in increased weight, insulin resistance, diabetes, metabolic syndrome...
Low SHBG was also shown to be associated with MetS
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COX-2 is overexpressed in a variety of human cancers i.e. colorectal, prostate, lung adenocarcinoma. This study hightlights the increased tumor metastatic potential via upregulation of VEGF-C via EP1 and HER-2 dependent pathways. This upregulation was correlated with survival and mets.
Hypercalcemia is a common finding in liver disease, especially cancer of the liver, whether primary or mets. Also, consider hyperparathyroidism and excessive vitamin D supplementation.
good read, though only abstract available here. Elevated Ferritin is usually caused by inflammation, chronic alcohol use, liver disease, renal failure, MetS, or cancer.
High TLR4 and MyD88 expression on the surface of colorectal cancer cells associated with increase liver mets potential and worsened prognosis. LPS works through TLR4 and MyD88.
PAK1 is an oncogene. Here that is linked to genesis of breast cancer through the RAS-RAF-MEK-ERK-MAPK pathway. Ivermectin, a common anti-parasitic, is know to block this oncogene activity.
Only abstract available here. Good discussion of the effects of curcumin: curcumin inhibits carcinogenesis, increases glutathione production, inhibits promotion and progression (mets) of cancer, induces cell apoptosis (cell death).