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Nathan Goodyear

ERβ inhibits proliferation and invasion of breast cancer cells - 0 views

www.ncbi.nlm.nih.gov/...PMC2040491

ER alpha ER beta ER-alpha ER-beta hormones cancer breast cancer prostate cancer ovarian cancer colon cancer

shared by Nathan Goodyear on 05 Jan 17 - No Cached
  • Nathan Goodyear on 05 Jan 17
     
    good review of the relationship of ERbeta and ERalpha in breast cancer.  A short review of other cancers also included.
Dubai Cosmetic Surgery

Laser Hair Removal in Dubai - 1 views

www.dubaicosmeticsurgery.com/...laser-hair-removal-in-dubai

hairremoval hair laser in Dubai UAE health Beauty healthCare

shared by Dubai Cosmetic Surgery on 25 Apr 16 - No Cached
  • Dubai Cosmetic Surgery on 25 Apr 16
     
    The reason why laser hair removal in Dubai has gained such outstanding popularity is because it's the least invasive and safe cosmetic procedure used to permanently remove unneeded body hair. With focused laser energy directed at the hair roots, melanin in the hair follicles is broken down hence preventing hair from growing permanently.
Nathan Goodyear

Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunolog... - 0 views

edrv.endojournals.org/...44.full

natural killer cells pregnancy loss recurrent immune system miscarriage NK

shared by Nathan Goodyear on 15 Apr 12 - No Cached
  • NK cells have been the cells most extensively studied, primarily because they constitute the predominant leukocyte population present in the endometrium at the time of implantation and in early pregnancy
  • parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infections, endocrine etiologies (luteal phase defect, thyroid dysfunction, uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombophilias, and alloimmune causes
  • estrogen
  • ...28 more annotations...
  • progesterone
  • prolactin
  • In summary, in vivo animal experiments have shown an inhibitory role of estrogen on peripheral NK cell lytic activity, which is partly due to suppression of NK cell output by the bone marrow and partly due to suppression of individual NK cell cytotoxicity. However, in vitro studies so far have failed to show conclusively a direct effect of estrogen on NK cells.
  • At the progesterone concentrations believed to be present in the uterus [up to 10−5 m at the maternal-fetal interface (35)], studies consistently show inhibition of lymphocyte proliferation (33) and inhibition of NK cytolytic activity in vitro
  • The exact role of prolactin in NK cell regulation is unknown.
  • The overall effects of estrogen on NK cells are likely multifactorial, therefore, and depend on the type of cell affected as well as the kind of ER expressed by that cell.
  • It is known that progesterone can directly affect T cell differentiation in vitro, suppressing development of the Th1 pathway and enhancing differentiation along the Th2 pathway (44)
  • Th1 cells predominantly produce interferon-γ (IFN-γ), IL-2, and TNF-β and are involved in cell-mediated immunity. Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 and stimulate humoral immunity
  • Furthermore, in response to progesterone, γδ T cells produce progesterone-induced blocking factor (PIBF) (54
  • A defining characteristic of NK cells is their ability to lyse target cells without prior sensitization and without restriction by HLA antigens.
  • NK cell function is mainly regulated by IL-2 and IFN-γ
  • IL-2 causes both NK cell proliferation and enhanced cytotoxicity. IFN-γ augments NK cytolytic activity, but does not cause NK proliferation. The two cytokines act synergistically to augment NK cytotoxicity (6).
  • The largest leukocyte population in the endometrium consists of NK cells named large granulated lymphocytes
  • there is a significant increase in the number of uNK cells throughout the secretory phase, which peaks in early pregnancy when uNK cells comprise about 75% of uterine leukocytes (62)
  • Second, uNK cell phenotype changes during the normal menstrual cycle and early pregnancy (68)
  • general proinflammatory effect of estrogen, causing an influx of macrophages and neutrophils, which is antagonized by progesterone through its receptor (70, 71).
  • The mechanism of such a progesterone-induced local immunosuppression is unclear.
  • progesterone plays an important role in proliferation and differentiation of uNK cells (32).
  • Through promotion of a uterine Th2 environment, progesterone could indirectly affect uNK cell function
  • The mechanism of this increase in uNK cell numbers has been addressed in both human and mouse models, and is likely the result of: 1) recruitment of peripheral NK cells to the uterus, and 2) proliferation of existing uNK cells
  • prolactin system plays an important role in implantation and the maintenance of pregnancy
  • the exact pathways of hormonal regulation of NK cells remain to be delineated.
  • The exact function of uNK cells has not yet been unequivocally determined
  • uNK cells express a different cytokine profile, compared with resting peripheral NK cells. mRNAs for granulocyte CSF, M-CSF, GM-CSF, TNF-α, IFN-γ, TGF-β, and leukemia inhibitory factor (LIF) have been found in decidual CD56+ cells
  • Their increased numbers in early pregnancy, their hormonal dependence, and their close proximity to the infiltrating trophoblast all suggest that they play an important role in the regulation of the maternal immune response to the fetal allograft and the control of trophoblast growth and invasion during human pregnancy
  • role of uNK cell-derived cytokines on trophoblast growth and differentiation (114, 115, 116, 117).
  • Th1 immunity to trophoblast is associated with RPL, whereas Th2 immunity is associated with a successful pregnancy
  • RPL is associated with Th1 immunity, for which NK cells are partly responsible.
  • Nathan Goodyear on 15 Apr 12
     
    dysregulated immune system plays role in recurrent miscarriage.  Specifically, this article discusses natural killer cells (NK).
Nathan Goodyear

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

www.sciencedirect.com/...S1535610810000826

prostate cancer 3-beta androstanediol male hormone hormones ER HIF-1alpha VEGF estrogen receptor receptors ER beta ER-beta

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  • Nathan Goodyear on 21 Jan 14
     
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
Nathan Goodyear

Estrogen receptor β2 and β5 are associated with poor prognosis in prostate ca... - 0 views

erc.endocrinology-journals.org/...675.short

ER beta ER-beta estrogen receptor receptors prostate cancer

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    Study finds that ER beta isomer type 2 and 4 increased prostate cancer aggressiveness.
Nathan Goodyear

Invasive fungal infection in systemic ... [Rheumatology (Oxford). 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17043051

Lupus SLE fungal infection infections yeast candida

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Lupus associated with increased fungal infections.
Nathan Goodyear

Assessment of bioavailability of oral micronized p... [Gynecol Endocrinol. 1993] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...8213223

saliva salivary hormone testing hormones progesterone bioidentical

shared by Nathan Goodyear on 16 Nov 10 - No Cached
  • The use of non-invasive salivary sampling and a cost-effective, direct enzymeimmunoassay showed a considerable advantage in the present study, compared with previous ones.
  • Nathan Goodyear on 16 Nov 10
     
    saliva testing verified as cost effective and with considerable advantage
Nathan Goodyear

Salivary testosterone for the diagnosis of androge... [Nephrol Dial Transplant. 2010] -... - 0 views

www.ncbi.nlm.nih.gov/...20659904

salivary testosterone saliva testing

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • These data demonstrate the value of morning Sal-T testing as a non-invasive approach to screen androgen status in ESRD patients.
  • Nathan Goodyear on 22 Nov 10
     
    Salivary Testosterone again validated
Nathan Goodyear

[Bone and Men's Health. Measurement of salivary te... [Clin Calcium. 2010] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...20118513

saliva salivary testosterone biodentical testng

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Testosterone is secreted into saliva. In saliva, testosterone is not bound to proteins. Thus concentration of testosterone in saliva is quite close to the serum free testosterone level. Currently serum free testosterone is measured by a convenient method in Japan, that reflects only 10% of the correct values. However, the correct measurement of serum free testosterone is quite costly. Collection of saliva is not invasive to subjects, and it can be done without paramedicals. Besides it is relatively cheaper. Acquisition of samples in multiple occasions is possible. These advantages of utilizing saliva will introduce the measurements of salivary testosterone in cohort studies or screening of low testosterone levels in the community.
  • Nathan Goodyear on 22 Nov 10
     
    Saliva Testing of Testosterone is standard
Nathan Goodyear

Saliva as a diagnostic tool in medical science : a review study. - Free Online Library - 0 views

www.thefreelibrary.com/e+:+a+review+study-a0215515436

saliva salivary testing

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Saliva is a wonderful marker of early disease detection that leads to more effective treatment, risk assessment for future oral and systemic disease, and a simple, non invasive alternative to blood and urine tests
  • Nathan Goodyear on 22 Nov 10
     
    saliva testing used in early disease detection
Nathan Goodyear

'Maternity blues' and hormone levels in saliva. [J Affect Disord. 1984] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...6235265

saliva salivary hormones hormone testing progesterone bioidentical

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • This pilot study has demonstrated the potential value of using a non-invasive technique (obtaining specimens of saliva) in conjunction with determinations of a predictable mood change.
  • Nathan Goodyear on 24 Nov 10
     
    salivary progesterone validated in mood evaluations
Nathan Goodyear

Cortisol in saliva--reference ranges and relation ... [Eur J Clin Chem Clin Biochem. 19... - 0 views

www.ncbi.nlm.nih.gov/...8845424

saliva cortisol salivary testing

shared by Nathan Goodyear on 20 Nov 10 - No Cached
  • In conclusion, the satisfactory precision of the analysis and the simple non-invasive sampling procedure suggest that saliva may be used for cortisol measurements in situations where blood sampling is difficult to perform.
  • Nathan Goodyear on 20 Nov 10
     
    saliva testing validated for cortisol
Nathan Goodyear

Inhibitors of Prostaglandin Synthesis Inhibit Human Prostate Tumor Cell Invasiveness an... - 0 views

cancerres.aacrjournals.org/...4629.full

omega-3 prostaglandin inhibitors prostate cancer

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Nathan Goodyear on 10 Feb 11
     
    omega-3 reduces aggressiveness of prostate cancer
Nathan Goodyear

Axillary Dissection vs No Axillary Dissection in Women With Invasive Breast Cancer and ... - 1 views

jama.ama-assn.org/...569.full

lymph node dissection breast cancer axillary

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Nathan Goodyear on 15 Feb 11
     
    axillary lymph node dissection not needed in many breast cancer clients
Nathan Goodyear

Salivary IgA antigliadin antibody as a marker for coeliac disease. - 0 views

www.ncbi.nlm.nih.gov/...PMC1793814

salivary IgA antigliadin antibodies celiac disease screening

shared by Nathan Goodyear on 06 Sep 11 - No Cached
  • Measurement of salivary IgA AGA provided excellent discrimination between those children with coeliac disease and the control groups, and our study suggests that it may provide a rapid, non-invasive method of screening for this disease before intestinal biopsy
  • Nathan Goodyear on 06 Sep 11
     
    salivary IgA antigliadin antibodies shown to be highly effective as screening tool for celiac disease
Nathan Goodyear

Axillary Dissection vs No Axillary Dissection in Women With Invasive Breast Cancer and ... - 0 views

jama.ama-assn.org/...569.abstract

axillary dissection breast cancer node

shared by Nathan Goodyear on 14 Apr 11 - No Cached
  • Nathan Goodyear on 14 Apr 11
     
    axillary lymph node dissection in breast cancer patients did not change survival rate when compared to sentinal Lymph node removal
Nathan Goodyear

Role of faecal calprotectin as non-invasive marker of intestinal inflammation - 0 views

www.sciencedirect.com/...S1590865803003815

Calprotectin inflammation GI gut

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Calprotectin useful as a marker of intestinal inflammation.
Nathan Goodyear

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteri... - 0 views

onlinelibrary.wiley.com/...FD615B31CBA2A30EB588D93.f01t03

ovarian cancer SHBG androgens women female

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    prospective study finds that increasing endogenous androgens is associated with low grade epithelial ovarian cancer and inversely associated with high-grade.
Nathan Goodyear

Best practice in the treatment of nonmuscle invasive bladder cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3263923

bladder cancer bladder cancer

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    2 year old "best practice" guidelines for bladder cancer.
Nathan Goodyear

Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation - 0 views

www.ncbi.nlm.nih.gov/...PMC3601023

cancer DCA

shared by Nathan Goodyear on 12 Nov 14 - No Cached
  • the oral bioavailability of DCA is nearly 100%
  • the oral bioavailability of DCA is almost 100%.
  • DCA can penetrate into the traditional chemotherapy sanctuary sites. Interestingly, it was reported that DCA could penetrate across the BBB,30 exhibiting the potential activity for brain therapy.
  • ...23 more annotations...
  • Clinical studies of DCA have shown reduced lactate levels
  • It has been reported that DCA activates the PDH by inhibition of PDK in a dose-dependent manner, and results in increased delivery of pyruvate into the mitochondria
  • The antitumor activity of DCA on nonsmall cell lung cancer, breast cancer, glioblastomas, and endometrial and prostate cancer cells has been demonstrated
  • It is well known that many chemotherapeutic agents have a low therapeutic index in brain tumors.
  • The most common metabolic hallmark of cancer cells is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen
  • Pyruvate dehydrogenase kinase (PDK) is a gate-keeping enzyme that regulates the flux of carbohydrates (pyruvate) into the mitochondria
  • In the presence of activated PDK, pyruvate dehydrogenase (PDH), a critical enzyme that converts pyruvate to acetyl-CoA instead of lactate in glycolysis, is inhibited, limiting the entry of pyruvate into the mitochondria.
  • the level of Hsp70 was significantly decreased
  • DCA can penetrate the BBB
  • It has been reported that DCA treatment resulted in an increase in the proportion of tumor cells in the S phase, showing a decrease in proliferation as well as the induction of apoptosis
  • Heat shock proteins (HSPs) are involved in protein folding, aggregation, transport, and/or stabilization by acting as a molecular chaperone, leading to the inhibition of apoptosis by both caspase-dependent and/or independent pathways
  • HSPs are overexpressed in a wide range of human cancers and are implicated in tumor cell proliferation, differentiation, invasion, and metastasis
  • Considering the fact that high expression of HSPs is essential for cancer survival, the inhibition of HSPs is an important strategy of anticancer therapy.
  • In addition, after 5 years of continued treatment with oral DCA at a dose of 25 mg/kg, the serum DCA levels are only slightly increased compared with the levels after the first several doses, also showing its safety for oral administration at this dose.
  • DCA can enter the circulation rapidly after oral administration and then generate the stimulation of PDH activity generally within minutes.
  • Our in vivo results in tumor tissues indicated that DCA significantly induced ROS production and decreased MMP in tumor tissues
  • The numbers of microvessels in the DCA treatment groups were significantly decreased, suggesting the potential antiangiogenic effect of DCA
  • Under hypoxic conditions, hypoxia-inducible factor (HIF-1α) is activated and induces angiogenesis
  • In addition, HIF-1α can also induce the expression of PDK,48 which can inhibit the activity of PDH
  • The inhibition effect of DCA on HIF-1α would decrease vascular endothelial growth factor and inhibit angiogenesis
  • the antiangiogenic effect in the 25 mg/kg treatment group was lower than that in 75 mg/kg or 125 mg/kg treatment groups
  • In conclusion, DCA induces the apoptosis of C6 cells through the activation of the mitochondrial pathway, arresting the cell cycle of C6 cells in S phase and down-regulating Hsp70 expression.
  • DCA significantly induced the ROS production and decreased the MMP in tumor tissues. Our in vivo antitumor activity results also indicated that DCA has an antiangiogenic effect
  • Nathan Goodyear on 12 Nov 14
     
    DCA as proposed therapy in cancer.
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