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Nathan Goodyear

EHP - Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for t... - 0 views

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    Polychlorinated biphenyl (PCBs) shown to disrupt thyroid hormone function through disruption of the transthyretin binding sites.  Not only is it a xenoestrogen, but it disrupts thyroid function too.
Nathan Goodyear

The use of salivary progesterone assays in the assessment of ovarian function in postme... - 0 views

  • indicate the value of salivary progesterone measurements in studies of ovarian function in adolescence.
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    The use of salivary progesterone assays in the assessment of ovarian function in postmenarcheal girls
Nathan Goodyear

Insulin Receptor Expression and Function in Human Breast Cancer Cell Lines - Cancer Res - 0 views

  • This present study indicates therefore that in breast cancer cell lines there are functional insulin receptors that regulate breast cancer cell growth.
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    breast cancer cells express high functioning insulin receptors
Nathan Goodyear

Thyroid Function Is Intrinsically Linked to Insulin Sensitivity and Endotheli... - 0 views

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    thyroid, insulin, and vascular function all linked; no linear thinking here
Nathan Goodyear

Sensitive salivary estradiol assay for monitoring ovarian function -- Worthman et al. 3... - 0 views

  • This assay may be particularly helpful in investigating ovarian function and free estradiol in women at various stages of the reproductive cycle.
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    salivary estradiol testing proves to be very helpful in evaluating ovaring function in women
Nathan Goodyear

Thieme eJournals - Abstract - 0 views

  • ur data showed that sHT patients exists impaired endothelial function, and antioxidant alpha-lipoic acid can improve endothelial function, through decrease of oxygen- derived free radicals.
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    IV alpha Lipoic acid shown to improve vascular function
Nathan Goodyear

The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older Eur... - 0 views

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    Testosterone, estradiol and sexual function in men
star yu

Stage 4 Kidney Disease with 28% Kidney Function Can I Live Like a Normal Person-Shijiaz... - 0 views

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    Stage 4 kidney disease with 28% kidney function can i live like a normal person ? In general, people with only 28% kidney function have to live with dialysis for the rest of their life, but fortunately, in our days they can have a chance to
Nathan Goodyear

Gonadal dysfunction in systemic diseases - 0 views

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    Systemic illness i.e. inflammation is associated with impaired HPA function and gonadal function.  This can be translated as low T.  Low Testosterone is a biomarker of poor health in men.
star yu

Kidney Failure with 25% Kidney Function Is It too Late to Take Micro-Chinese Medicine O... - 0 views

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    I am a kidney failure patient with only 25% of kidney function. Is it too late for me to take Micr-Chinese Medicine Osmotherapy ? In fact, as long as you still have urine, you can take this kind of medicine, it can help to improve your kidney function gradually.
Nathan Goodyear

Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Andro... - 0 views

  • in male obesity basal and LH-stimulated androgen levels are reduced and inversely correlated with circulating leptin
  • functional leptin receptors are present in rodent Leydig cells
  • it is conceivable that in males high leptin concentrations may have a direct inhibitory effect(s) on Leydig cell function.
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  • insulin is an important inhibitor of the synthesis of SHBG
  • no correlation between leptin and SHBG levels
  • SHBG reduction in obesity is a minor determinant of lowered androgen levels
  • SHBG can explain only up to 3% of the correlation
  • testicular T de novo production is impaired in obese men and that leptin seems to be the best hormonal predictor of this blunted response to LH stimulation
  • The low basal 17-OH-P levels found in massively obese men are consistent with a global impairment of Leydig cell steroidogenic function in this group of subjects.
  • These findings indicate that obese men have a FM-related defect in the enzymatic conversion of 17-OH-P to T, which is revealed by hCG stimulation.
  • Other studies have investigated the adrenal function in male obesity and have shown that basal cortisol and 17-OH-progesterone levels tend to decrease with the increase in the degree of obesity
  • High E2 can inhibit the expression and activity of the 17,20-lyase and may be responsible for this steroidogenic lesion
  • However, stimulated E2 levels were not higher in the obese than in controls, excluding the fact that the lower androgen response was due to an increased aromatization of T to E2 and that estrogens have a major role in the observed defect of 17,20-lyase activity in obese men.
  • the percentage increase in the 17-OH-progesterone to T molar ratio paralleled the increase in leptin levels of obese men
  • Multiple regression analysis indicated that the best hormonal predictor of the obesity-related reduction in T and FT basal levels and androgen changes after hCG stimulation was serum leptin concentration
  • insulin has no negative influences on androgen production in obese men
  • insulin is known to have stimulatory actions on T production that have been demonstrated in obese and normal weight men (57) and in Leydig cells in culture
  • the negative correlation between insulin and basal T can be partly explained by the inhibitory action of insulin on SHBG production
  • hypogonadal men have higher circulating leptin levels compared with hypogonadal patients under effective androgen substitution therapy
  • The impaired androgen response to LH stimulus was due to a defect in the enzymatic conversion of 17-OH-progesterone to T, which was disclosed by a leptin-related increase in 17-OH-progesterone to T ratio
  • Estrogens, which are inhibitory modulators of LH pulsatility and bioactivity
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    Leptin appears to be a good marker of low Testosterone.  This study proposes that the mechanism of action is potentially 2 fold: first, a decrease in LH release by leptin (kisspeptin?) and 2nd, a directed decrease in Testosterone production by the leydig cells in the testes.
wheelchairindia9

Ergo Lite 2 - 0 views

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    Lightweight Ergonomic Wheelchair is designed to cradle patients in comfort while reducing risk of pressure sores, relieving pressure, dispersing weight evenly and improving stability. The Ergo Lite Wheelchair is easy to lift and its small size makes it ideal for travel. Weighing only 19.8 lbs., the chair is easy to store and transport. The chair folds down the middle like a standard wheelchair and the backrest also folds down to make the wheelchair even more compact. The Karman wheelchairs are exceptional in both their function and style. With comfort built right into the frame of a wheelchair eliminating the need for a "thick cushion" to add comfort, S-Shape seat allows the wheelchair to be "ergonomically correct" putting into a seating position and comfort conforming to natural body's curves. These chairs are built for comfort and quality to stand the test of time. Karma S Ergo 305 Wheelchair: The Karma S Ergo 305 Wheelchair weighs only 13 kg, has a 115 kg weight capacity and is available in 16" and 18" seat widths. With wheels and footrest removed this chair weighs 10 kg. Karma S Ergo 305 Wheelchair Features: Only 10 kg. (w/ wheels & footrests removed) Folding backrest, for transporting chair in car, bus, trips, ect. Swing in & away footrest for maximum safety while entering or exiting the chair 24" Quick Release rear spoke/polyurethane/high profile/flat free wheels & 7×1" front casters Seat Width: 18"x17" OR 16" x 17" Upholstery: Silver/Black mesh AEIGIS back and seat cushion Height Adjustable Armrest Factory Height Settings should be selected at time of purchase for convenience High strength, weighs only 13 kg. (w/o footrests) Anti-Bacterial Upholstery/Cushion Flip back armrests w/ wider contoured arm pads for maximum comfort "Tube-in Center" foot-plate, assures better side leg support Frame Color: Pearl Silver & Rose Red Axle Adjustable Seat Height ( 18", 19", 20") Weight Capacity: 115 kg. Karma KM 2512 Ergo Lite 2 Wheel
wheelchairindia9

Tynor Frog Splint - 0 views

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    Tynor Frog Splint Frog-Splint Provides perfect alignment of the inter-phalangeal joints by maintaining them in optimal functional position. Malleable arms fold to hold the finger in the finger in the desired position. No tapes required. Light weight Softened arms for good grip Comfortable cushioning Hypo allergenic Tynor Frog Splint Features Coated aluminum body Extra malleable arms, can be shaped for good grip Strong, provides rigid immobilization Aesthetically pleasing Light weight Anatomic design Immobilizes both interphalangeal joints in neutral functional position Ensures easy wearing during injury Well ventilated and comfortable Does not restrict the movement of other fingers. Sleek, simple and light in weight Ethafoam lining High cushioning Enhanced comfort Easy to clean and maintain. Hypoallergenic, odorless Tynor Frog Splint Measurements Length of Fingers Size Chart- Size Inches CM Small Below 2 Below 5 Medium 2-3 5-7.5 Large 3-4 7.5-10
wheelchairindia9

Tynor Hand Resting Splint Right-Left - 0 views

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    Tynor Hand Resting Splint Right-Left provides great help during orthopedic conditions and also keeps the wrist in the functional position. It has an aluminum dorsal and volar splints which provide strong support and keep the wrist immobilized. It has PUF lined Matty Fabric body which is light in weight and allows to carry this hand resting splint anywhere. Its Amphi-dextrous two part design gives a perfect fit around the wrist and this hand resting splint fits to all circumference. It can compress and adjust this splint as per the need. Tynor Hand Resting Splint Right-Left Features Provides splinting support to the hand Firmly holds the hand in various orthopedic conditions Maintains the hand in the functional position Has Amphi-dextrous design Easy to use and remove Has Customizable splints Comes with aluminum dorsal and volar splints Provides Rigid and strong support Gives Perfect fit and enhances the comfort Light in weight Has PUF lined Matty Fabric body Durable and Long in length Can be used for mid forearm fractures Tynor Hand Resting Splint Right-Left Measurements Measure circumference evenly around wrist joint
Nathan Goodyear

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epitheli... - 0 views

  • we functionally validated a potent EOC oncogene, KPNB1, and showed its clinical relevance to human EOC
  • a well-established antiparasitic drug, ivermectin, has antitumor effects on EOC through its inhibition of KPNB1
  • EOC has high intertumor and intratumor heterogeneity at the molecular and epigenetic levels
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  • the mortality rate of EOC has not been significantly changed for several decades
  • Sequencing revealed that almost all tumors (96%) had mutations in TP53, which serves as a major driver of this cancer
  • Low-prevalence but statistically significant mutations in nine other genes including NF1, BRCA1, BRCA2, RB1, and CDK12 were also identified, but the majority of genes were mutated at low frequency, making it difficult to distinguish between driver and passenger mutations
  • KPNB1 inhibition via any of three KPNB1 siRNAs or importazole treatment induced apoptosis in human EOC cell lines (Fig. 3 A–F and Fig. S4), and was accompanied by an increase in the expression levels of the proapoptotic proteins BAX and cleaved caspase-3
  • Stable overexpression of KPNB1 in SKOV3 and OVCAR3 (Fig. S6) significantly accelerated cell proliferation/survival (Fig. 5 A–C), confirming that KPNB1 functions as an oncogene in EOC
  • KPNB1 overexpression significantly decreased caspase-3/7 activity (Fig. 5D), in addition to the expression levels of cleaved caspase-3 and BAX proteins (Fig. 5E). KPNB1 overexpression also decreased p21 and p27 protein levels (Fig. 5E), as opposed to their increase by KPNB1 inhibition
  • KPNB1 functions as an antiapoptotic and proproliferative oncogene in EOC.
  • Patients with higher expression levels of KPNB1 showed earlier recurrence and worse prognosis than those with lower expression levels of KPNB1
  • KPNB1 acts as an oncogene in human EOC and represents a promising therapeutic target.
  • ivermectin treatment suppressed cell proliferation/viability in a dose-dependent manner (Fig. 7A), indicating that it exerts an antitumor effect on EOC
  • ivermectin also induced apoptosis
  • ivermectin increased the expression levels of BAX, and cleaved PARP, as well as p21 and p27
  • KPNB1 inhibition is responsible for the antitumor effect of ivermectin
  • we found that ivermectin synergistically reduced cell proliferation/viability in combination with paclitaxel in human EOC cells
  • Single treatment of ivermectin or paclitaxel reduced tumor growth in nude mice, but, notably, combination treatment of ivermectin and paclitaxel almost completely suppressed tumor growth
  • ERBB2, is amplified and overexpressed in many cancers, including breast (31), ovary (31), colon (32), bladder (33), non-small-cell lung (34), and gastric cancer (35), and is a poor prognostic factor in certain cancer types
  • KPNB1 was the second-highest-ranked gene identified in our screen
  • Increased KPNB1 protein levels have been reported in several cancers, including cervical cancer (42), hepatocellular carcinoma (43), and glioma (44), suggesting KPNB1’s oncogenic potential in these tumor types
  • our findings suggest that KPNB1 might serve as a master regulator of cell cycle by regulating several cell cycle-related proteins, including p21, p27, and APC/C family members
  • higher and/or more-frequent doses of ivermectin than currently approved for humans are well tolerated in humans
  • none of the mice in this study treated with the effective dosage of ivermectin for in vivo anticancer therapy showed severe adverse event
  • we found that the combination of ivermectin and paclitaxel produces a stronger antitumor effect on EOC cell lines than either drug alone
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    Ivermectin found to be pro-apoptotic for the epithelial ovarian cancer oncogene, KPNB1 in in Vivo study.  This effective anti-parasitic drug inhibits the KPNB1 oncogene.
Nathan Goodyear

Resistance-Based Interval Exercise Acutely Improves Endothelial Function In Type 2 Diab... - 0 views

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    resistance/cardio interval training found to improve vascular endothelial function.
Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumat... - 0 views

  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter [61], [62], [63], [64], has positive effect upon the myelinization and maturation of injured neural fibers [65], and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
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  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration [67].
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow [58], [59], [68], [69], promote blood brain barrier integrity and reduce inflammatory reactions [28] as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
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    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host -... - 0 views

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    Studies have found that high-salt diet can enhance the function of natural killer (NK) cells by enriching the abundance of Bifidobacterium, thus inhibiting tumor growth (63). High dietary fiber can enrich A. muciniphila, activate innate immunity, reshape the tumor microenvironment, and exert the function of inhibiting tumor (64). Notably, Wargo et al. have confirmed that high-dietary fiber diet can enhance anti-tumor immunity and increase the infiltration of tumor-killing T cells, while commercial probiotics treatment alone does not enhance the efficacy of immunotherapy. This study suggests that probiotics intervention is strain-specific and should be put in a specific dietary environment to make sense, to some extent (65).
Nathan Goodyear

Mapping and Characterization of the Functional Domains Responsible for the Differential... - 0 views

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    different functions of PR-A and PR-B.
Nathan Goodyear

Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and... - 0 views

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    weight gain and obesity are associated with a dysfunctional HPA axis and low testosterone in men.  Reduction in weight will restore HPA axis function.
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