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Nathan Goodyear

Function and Activation of NF-kappaB in the Immune System - Annual Review of Immunology... - 0 views

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    NF-KappaB and activation of the Immune System
Nathan Goodyear

Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Me... - 0 views

  • High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state.
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    elevated serum rT3 indicates tissue hypothyroidism; very different than rT3 in the pituitary, where high concentrations accumulate
Nathan Goodyear

The Failure of Physiologic Doses of Reverse T3 to Effect Thyroid-Pituitary Function in ... - 0 views

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    reverse T3 does not block T4 to T3 converson; but occupies T3 receptors and inhibits T3 stimulating receptors
Nathan Goodyear

ingentaconnect Immunonutrition in Surgical Patients - 0 views

  • Surgery induces an inflammatory response
  • A range of nutrients, including several amino acids, antioxidant vitamins and minerals, ω-3 fatty acids, and nucleotides, are able to modulate inflammation and the associated oxidative stress, and maintain or improve immune function
  • parenteral glutamine is recommended in patients receiving parenteral nutrition
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  • Antioxidants, particularly selenium, should be considered for critically ill patients
  • enteral formulas enriched with fish oils are recommended for patients with acute respiratory distress syndrome.
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    nutrition to improve inflammation in surgical patiens
Nathan Goodyear

Arch Intern Med -- Abstract: The Progressive Cost of Complications in Type 2 Diabetes M... - 0 views

  • Per-person costs increased over baseline ($2033) by more than 50% ($1087) after initiation of cardiovascular drug therapy and/or use of a cardiologist, and by 360% ($7352) after a major cardiovascular event. Abnormal renal function increased diabetes treatment costs by 65% ($1337); advanced renal disease, by 195% ($3979); and end-stage renal disease, by 771% ($15,675)
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    Costs of "poor health"
Nathan Goodyear

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity... - 0 views

  • SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function
  • central role of NF-κB in cytokine-mediated pancreatic β-cell damage
  • SIRT1 as a possible target to attenuate cytokine-induced β-cell damage.
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    SIRT1 as possible target to reduce pancreatic inflammation and thus prevent/reduce diabetes;  Oh by the way Resveratrol acts at SIRT1
Nathan Goodyear

ScienceDirect - Journal of Functional Foods : Effects of l-theanine on attention and re... - 0 views

  • Results evidently demonstrated that l-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects prone to have high anxiety.
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    l-Theanine for attention and anxiety
Nathan Goodyear

Ovulatory and metabolic effects of D-chiro-inosito... [N Engl J Med. 1999] - PubMed result - 0 views

  • Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations.
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    Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome
Nathan Goodyear

Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment... - 0 views

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    DHA supplementation in mother increased DHA phosopholipid levels in infant; though no change in neurodevelopment was noted
Nathan Goodyear

Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Relat... - 0 views

  • The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6
  • Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk
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    leptin resistance, inflammation and obesity
Nathan Goodyear

1210_article_14 - 0 views

  • These modulatory effects - which most likely involve binding with functional thiol residues - are interwoven with neurotoxic actions of both mercurials.
  • THIM is metabolized in the body to ethyl mercury (EtHg) and subsequently to inorganic mercury forms, which accumulate in tissues of vital organs, including the brain (22). Information about neurochemical and neurotoxic effects of THIM is still limited, but the existing data indicate that in pharmacodynamics and toxicity THIM/EtHg does not differ significantly from methyl mercury (MeHg), which has been studied more extensively, although these compounds differ somewhat in pharmacokinetics (8).
  • Several studies documented that the neurotoxic effects of mercurials involve glutamate-mediated excitotoxicty, due to their ability to inhibit uptake of glutamate in astrocytes, resulting in an increase of the extracellular level of this excitatory amino acid
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    neurotoxic effects of thimerosal
Nathan Goodyear

Toxic environment and obesity pandemia: is there a... [Ital J Pediatr. 2010] - PubMed r... - 0 views

  • Recent cumulating evidence suggests that obesity may represent an adverse health consequence of exposure during the critical developmental windows to environmental chemicals disrupting endocrine function. Moreover, exposure to these chemicals seems to play a key role in the development of obesity-related metabolic and cardiovascular diseases.
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    Toxic environment and obesity
Nathan Goodyear

Glucagon-like peptide 1 improves the ability of th... [Diabetes. 1998] - PubMed result - 0 views

  • We concluded that low dosage GLP-1 improves the ability of the beta-cell to secrete insulin in both IGT and NIDDM subjects, but that the ability to sense and respond to subtle changes in plasma glucose is improved in IGT subjects, with only a variable response in NIDDM subjects. Beta-cell dysfunction was improved by GLP-1 infusion, suggesting that early GLP-1 therapy may preserve beta-cell function in subjects with IGT or mild NIDDM.
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    glucagon-like peptide-1 improves insulin/glucose regulation
Nathan Goodyear

Molecular basis of cadmium toxicity. [Prog Food Nutr Sci. 1984] - PubMed result - 0 views

  • Cadmium inhibits protein synthesis, carbohydrate metabolism and drug metabolizing enzymes in liver of animals.
  • Cadmium affects both humoral and cell mediated immune response in animals
  • cadmium nephropathy
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  • produces hypertension
  • It causes an alterations of cellular functions in lungs
  • Cadmium is also toxic to central nervous system
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    for you biochemistry junkies, the molecular pathophysiology of cadmium oxicity
Nathan Goodyear

Biological and health implications of toxic heavy ... [Prog Food Nutr Sci. 1987] - PubM... - 0 views

  • hey are cumulative poison, and are toxic even at low dose
  • These metals serve no biological function and their presence in tissues reflects contact of the organism with its environment
  • heavy metals cadmium, lead, and mercury are specially prevalent in nature due to their high industrial use
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    implications of heavy metal toxicity
Nathan Goodyear

Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discov... - 0 views

  • when vitamin C is ingested by mouth, plasma and tissue concentrations are tightly controlled by at least 3 mechanisms in healthy humans: absorption, tissue accumulation, and renal reabsorption
  • 4th mechanism, rate of utilization, may be important in disease
  • Ascorbate administered intravenously has already been tested in a phase I clinical trial, is in wide use by complementary and alternative medicine (integrative medicine) practitioners, and appears to have minimal side effects in patients who are properly screened.
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    Fantastic review on IV Vitamin C therapy
Nathan Goodyear

Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric ... - 0 views

  • beneficial effect of vitamin C on vascular endothelial function appears to be mediated in part by protection of tetrahydrobiopterin and restoration of eNOS enzymatic activity
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    Vitamin C helps to preserve tetrahydrobiopterin levels
Nathan Goodyear

STIMULATION TESTS OF PITUITARY-LEYDIG CELL FUNCTION IN NORMAL MALE SUBJECTS AND HYPOGON... - 0 views

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    HCG and clomid stimulation tests helpful in differentiating male hypogonadism
Nathan Goodyear

Divergence of gut permeability and mucosal immune gene expression in two glut... - 0 views

  • GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.
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    Gluten sensitivity a result of the innate immunity
Nathan Goodyear

Salivary cortisol and DHEA levels in the Korean po... [Yonsei Med J. 2007] - PubMed result - 0 views

  • As the cortisol and DHEA levels in saliva reflected those in serum, the measurement of steroid levels in saliva provide a useful and practical tool to evaluate adrenal functions, which are essential for clinical diagnosis.
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    salivary cortisol and DHEA validated.  
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