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Nathan Goodyear

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

www.sciencedirect.com/...S1931312816305170

gut gut bacteria gut flora gut health gut microbiome gut microbiota diet nutrition

shared by Nathan Goodyear on 02 Jan 17 - No Cached
  • Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
  • Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
  • Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
  • Nathan Goodyear on 02 Jan 17
     
    Diet is the key to gut microbe diversity.  Gut microbes are key to maintaining optimal cellular metabolism.  Nutrition can be a prescription for improving and reprogramming gut bacteria.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

gut flora gut microbiome gut microbiota estrogen metabolites metabolism hormone hormones women gut

shared by Nathan Goodyear on 06 May 15 - No Cached
  • Nathan Goodyear on 06 May 15
     
    women with increased gut microbiome diversity found to have increased estrogen metabolites compared to parent estrogen i.e. gut microbiome diversity in women effects estrogen metabolism. 
Nathan Goodyear

Testosterone: More Than Having the Guts to Win the Tour de France - 0 views

www.sciencedirect.com/...S1074761313003439

Testosterone gut flora gut microbiome gut microbiota autoimmune disease diabetes

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • female adult mice have microbiomes similar to those of prepubescent mice of both sexes;
  • the commensal microbial community in adult male mice significantly deviates from this shared initial pool.
  • the microbiome in castrated adult males clearly shifts away from that of normal adult males and is closer to the microbiome of females
  • ...10 more annotations...
  • The incidence of T1D in these mice is positively correlated with the “femaleness” of the microbiota
  • These results support the hypothesis that the host androgen level is influential in determining the composition of the microbiota, which in turn affects T1D initiation and progression
  • a high testosterone level enriches the microbiota for specific organisms such as segmented filamentous bacteria (SFB) and Escherichia coli or Shigella–like (SECS) strains.
  • A minimum level of testosterone and specific male-enriched microbes working together upregulate M2 macrophage and IFN-γ producing T cells in pancreatic lymph nodes. Microarray data show that both the IFN-γ and IL-1β pathways are also stimulated.
  • These microbes also upregulate host testosterone
  • In four independent experiments, the authors found no universal unique “male microbiome”
  • they did find that four distinct combinations of microbial groupings (with an interesting lack of overlap at the individual family level in the four experiments) were enhanced by androgen
  • one species consists of the segmented filamentous bacteria (SFB) and belongs to the Firmicutes, whereas the other is an Escherichia coli or Shigella–like (SECS) strain belonging to the Proteobacteria
  • colonization with protective microbiomes—e.g., SPF microbiota, SFB, and SECS—is positively correlated with high blood testosterone levels in male mice
  • A direct implication of this study is that probiotic administration or fecal transplantation is a theoretically possible approach to protection against T1D
  • Nathan Goodyear on 30 Apr 15
     
    nice summary of article on the relationship between Testosteorne and gut microbiome in autoimmune disease.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

estrogen metabolites gut flora gut microbiome gut microbiota hormones cancer breast cancer microbiome estrogen

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    Post-menopause women with increased gut microbiome diversity found to be associated with increased urinary excretion of estrogen metabolites compared to parent estrogens.  This relationship has been shown to be associated with a reduced breast cancer risk.
Nathan Goodyear

Investigation of the association between the fecal microbiota and breast cancer in post... - 0 views

www.ncbi.nlm.nih.gov/...26032724

breast cancer women hormones gut flora gut microbiome gut microbiota cancer

shared by Nathan Goodyear on 16 Sep 15 - No Cached
  • Nathan Goodyear on 16 Sep 15
     
    women with post menopause breast cancer have altered gut flora compared to women without.
Nathan Goodyear

The use of fecal calprotectin and la... [Acta Gastroenterol Belg. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24261027

calprotectin lactoferrin inflammation IBD IBS inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Useful biomarkers: calprotectin and lactoferrin used to follow GI inflammation.  Calprotectin is useful to follow inactive/active IBD.  It also has been show to predict recurrence and can aid in differentiation between IBD and IBS.  Lactoferrin appears to be a biomarker more useful in GI inflammation.
Nathan Goodyear

Role of fecal calprotectin as a biomarker ... [Inflamm Bowel Dis. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16775498

calprotectin inflammation IBD inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Calprotectin useful marker in assessment of colonic inflammation.
Nathan Goodyear

Fecal calprotectin is a surrogate marker f... [Inflamm Bowel Dis. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22344983

Calprotectin IBD inflammation inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Calprotectin useful as biomarker to follow remission/active IBD disease.  
Nathan Goodyear

Frontiers | Bacterial Composition, Genotoxicity, and Cytotoxicity of Fecal Samples from... - 0 views

journal.frontiersin.org/...full

diet nutrition gut bacteria gut gut flora inflammation gut health gut microbiome gut microbiota

shared by Nathan Goodyear on 08 May 17 - No Cached
  • Nathan Goodyear on 08 May 17
     
    Diet influenced gut bacteria is key to controlling gut inflammation.
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