Skip to main content

Home/ Dr. Goodyear/ Group items tagged dosing

Rss Feed Group items tagged

Nathan Goodyear

Mumps Outbreak in Orthodox Jewish Communities in the United States - NEJM - 0 views

  •  
    2009 study finds that in 3502 cases of mumps, 97% of the adolescents had received the mumps vaccine (89% 2 doses and an additional 9% 1 dose).
Nathan Goodyear

Intravenous vitamin C as a chemotherapy age... [P R Health Sci J. 2004] - PubMed - NCBI - 0 views

  •  
    IV vitamin C shown to be beneficial in treatment of renal cell cancer, colorectal cancer, pancreatic cancer, non-Hodgkin's lymphoma, and breast cancer without toxic side effects.  The doses provided here were high dose and these are patients that are very unhealthy.
Nathan Goodyear

Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testost... - 0 views

  •  
    Study looked at aromatase activity in androgen production in older men.  The study found that aromatase inhibition with arimidex increased Testosterone production.  PSA was also monitored and PSA increased in the smaller dose group versus the high dose group.
Nathan Goodyear

Vitamin D status and ill health: a systematic review : The Lancet Diabetes & Endocrinology - 0 views

  •  
    Another ill conceived conclusion by the authors.  IF you are going to study something, know everything about it.  They authors make a major statement about vitamin D, yet they seem to understand a basic understanding of vitamin dosing.  The authors stated that dosing 2,000 IU of vitamin D in those with levels < 50 provided no benefit.  That is of course correct, because 2,000 IU daily won't hold any levels stable, let alone increase levels to 70-80 where they need to be.  The authors of this study are stuck in the traditional RDC thinking here. What is interesting is that low vitamin D was associated with CVD, MS, dyslipidemia, inflammation, glucose dysmetabolism, infections, mood disorders, decline in cognition, impaired physical functioning, and all-cause mortality,  But, vitamin D supplementation is only good for bones.  The authors of this study make a mockery of medicine.
Nathan Goodyear

Effects of vitamin D supplementation on gluco... [Am J Clin Nutr. 2013] - PubMed - NCBI - 0 views

  •  
    Vitamin D3 replacement was found to decrease fasting glucose, decrease insulin, increase insulin sensitivity, and decrease total cholesterol and LDL in pregnant women with gestational diabetes.  The dosing here was 50,000 IU x 2 doses taken 3 weeks apart. 
Nathan Goodyear

Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight su... - 0 views

  •  
    Astaxanthin at 20 mg found to reduce oxidized LDL and other oxidative stress biomarkers as assessed by Malondialdehydy, SOD, Isoprostane, and TAC.  The dose was 20 mg for 12 weeks. This higher dose was associated with minimal side effects--red stools.
Nathan Goodyear

Calcium and vitamin d supplementation decreases incidence of stress fractures in female... - 0 views

  •  
    low dose vitamin D plus higher dose of calcium reduced stress fractures in female military recruits.
Nathan Goodyear

Hormonal Regulation of Circulating C-Reactive Protein in Men - 0 views

  •  
    High dose of estrogen associated with increase CRP in men.  Definitely a dose dependent response.
Nathan Goodyear

Oxycodone Plus Ultra-Low-Dose Naltrexone Attenuates Neuropathic Pain and Asso... - 0 views

  • The antihyperalgesic and antiallodynic effects of oxycodone plus ultra-low-dose NTX (Oxytrex, Pain Therapeutics, Inc., San Mateo, CA) suggest a promising new treatment for neuropathic pain.
  •  
    low dose naltrexone plus opiate therapy improves neuropathic pain
Nathan Goodyear

Evaluation of gabapentin in management of hot flushes in postmenopausal women - 0 views

  •  
    Study finds non-hormonal therapy to manage hot flashes in postmenopausal women--drug them.  The authors of this study, looked to gabapentin, also known as neurontin to treat hot flashes.  Instead of looking at the causes: hormone imbalance, stress... these authors looked to a sedating drug.  The dosing of neurontin was 900 mg.   Most can't stand at this dose.  This study points to the lunacy in the research today.  Very soon, there will be the walking dead among us.  They will be the walking doped instead of dead.
Nathan Goodyear

Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation - 0 views

  • the oral bioavailability of DCA is nearly 100%
  • the oral bioavailability of DCA is almost 100%.
  • DCA can penetrate into the traditional chemotherapy sanctuary sites. Interestingly, it was reported that DCA could penetrate across the BBB,30 exhibiting the potential activity for brain therapy.
  • ...23 more annotations...
  • Clinical studies of DCA have shown reduced lactate levels
  • It has been reported that DCA activates the PDH by inhibition of PDK in a dose-dependent manner, and results in increased delivery of pyruvate into the mitochondria
  • The antitumor activity of DCA on nonsmall cell lung cancer, breast cancer, glioblastomas, and endometrial and prostate cancer cells has been demonstrated
  • It is well known that many chemotherapeutic agents have a low therapeutic index in brain tumors.
  • The most common metabolic hallmark of cancer cells is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen
  • Pyruvate dehydrogenase kinase (PDK) is a gate-keeping enzyme that regulates the flux of carbohydrates (pyruvate) into the mitochondria
  • In the presence of activated PDK, pyruvate dehydrogenase (PDH), a critical enzyme that converts pyruvate to acetyl-CoA instead of lactate in glycolysis, is inhibited, limiting the entry of pyruvate into the mitochondria.
  • the level of Hsp70 was significantly decreased
  • DCA can penetrate the BBB
  • It has been reported that DCA treatment resulted in an increase in the proportion of tumor cells in the S phase, showing a decrease in proliferation as well as the induction of apoptosis
  • Heat shock proteins (HSPs) are involved in protein folding, aggregation, transport, and/or stabilization by acting as a molecular chaperone, leading to the inhibition of apoptosis by both caspase-dependent and/or independent pathways
  • HSPs are overexpressed in a wide range of human cancers and are implicated in tumor cell proliferation, differentiation, invasion, and metastasis
  • Considering the fact that high expression of HSPs is essential for cancer survival, the inhibition of HSPs is an important strategy of anticancer therapy.
  • In addition, after 5 years of continued treatment with oral DCA at a dose of 25 mg/kg, the serum DCA levels are only slightly increased compared with the levels after the first several doses, also showing its safety for oral administration at this dose.
  • DCA can enter the circulation rapidly after oral administration and then generate the stimulation of PDH activity generally within minutes.
  • Our in vivo results in tumor tissues indicated that DCA significantly induced ROS production and decreased MMP in tumor tissues
  • The numbers of microvessels in the DCA treatment groups were significantly decreased, suggesting the potential antiangiogenic effect of DCA
  • Under hypoxic conditions, hypoxia-inducible factor (HIF-1α) is activated and induces angiogenesis
  • In addition, HIF-1α can also induce the expression of PDK,48 which can inhibit the activity of PDH
  • The inhibition effect of DCA on HIF-1α would decrease vascular endothelial growth factor and inhibit angiogenesis
  • the antiangiogenic effect in the 25 mg/kg treatment group was lower than that in 75 mg/kg or 125 mg/kg treatment groups
  • In conclusion, DCA induces the apoptosis of C6 cells through the activation of the mitochondrial pathway, arresting the cell cycle of C6 cells in S phase and down-regulating Hsp70 expression.
  • DCA significantly induced the ROS production and decreased the MMP in tumor tissues. Our in vivo antitumor activity results also indicated that DCA has an antiangiogenic effect
  •  
    DCA as proposed therapy in cancer.
Nathan Goodyear

Efficacy of Melatonin in the Immunotherapy of Cancer Using lnterleukin-2 | SpringerLink - 0 views

  •  
    Low dose IL-2 + high dose melatonin increases 1 year survival in the treatment of solid tumors in pilot study.
Nathan Goodyear

https://www.researchgate.net/publication/15174945_Cancer_immunotherapy_with_low-dose_in... - 0 views

  •  
    Increased disease stabilization and lack of progression of solid tumor disease with low dose IL-2 and high dose melatonin.
Nathan Goodyear

Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasm... - 0 views

  •  
    Study finds that vitamin C inhibits pro-oxidant effects of artesunate at doses of 400 microM/L; Same with doxycycline. The problem here is that that translates to 5 mg/dL of vitamin C. Studies have shown that vitamin C's effect in cancer is attributable in part to its dose and the presence of metals.
Nathan Goodyear

Role of Vitamin C in Skin Diseases - 0 views

  •  
    High dose IV vitamin C effective against melanoma review finds. Low dose appears to promote melanoma.
Nathan Goodyear

renal dosing of antibiotics - 0 views

  •  
    Renal dosing of antibiotics
Nathan Goodyear

Clinical Pharmacodynamic Effects of the Growth Hormone Receptor Antagonist Pegvisomant:... - 0 views

  •  
    Pegvisomant shown to provide more GH, IGF-1 suppression compared to octreotide. The doses used were 40, 60, and 80 mg SQ. The higher dose resulted in the greatest suppression.
Nathan Goodyear

Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in ... - 0 views

  • Obesity and models of obesity induced by ingestion of HF-diet in rodents are associated with chronically elevated circulating levels of LPS
  • chronic low-dose administration of LPS induces leptin-resistance in vagal afferent neurons and abolition of CCK-induced inhibition of food intake
  • HF fat feeding has been shown to enhance gastrointestinal permeability promoting the translocation of LPS to the circulation
  • ...9 more annotations...
  • LPS leads to an increase in SOCS3 expression [20]. SOCS3 is a negative regulator of leptin signaling
  • We observed a significant increase in energy intake in the LPS-treated rats
  • the data provides a mechanism linking changes in gut microbiota induced by ingestion of HF diets to dysregulation of food intake and body weight
  • Chronic low-dose LPS treatment induced TLR4 activation and MyD88 signaling in vagal afferent neurons, associated with increased SOCS3 expression and reduced leptin-signaling, characterized by the absence of leptin-induced pSTAT3.
  • SOCS3 is an important mechanism by which leptin resistance develops in vagal afferent neurons and coincides with the onset of hyperphagia
  • We demonstrate that this chronic low dose LPS is sufficient to induce leptin–resistance in vagal afferent neurons, reduced sensitivity to the satiating effects of CCK, and loss of vagal afferent plasticity
  • it suggests that the increase in food intake and body weight we observed at week 6 in the LPS treated rats may be caused by LPS-induced leptin resistance.
  • chronic LPS treatment of mice for four weeks increased body weight
  • chronic LPS treatment of mice for four weeks increased subcutaneous fat
  •  
    Very interesting study.  High fat diet in rats induced gut flora change that resulted in LPS which induced appetite through leptin resistance and reduced cholecystokinin signaling.
Nathan Goodyear

High Dose IV Vitamin C and Metastatic Breast Cancer: A Case Report - ISOM - 0 views

  •  
    Case study of vitamin C IV up to 75 grams IV effective in stabilizing breast cancer with mets to liver.
Nathan Goodyear

Treatment of pancreatic cancer with intravenous vitamin C: a... : Anti-Cancer Drugs - 0 views

  •  
    High dose vitamin C found to be effective in partial regression of pancreatic cancer.
« First ‹ Previous 61 - 80 of 676 Next › Last »
Showing 20 items per page