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Nathan Goodyear

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men - 0 views

www.ncbi.nlm.nih.gov/...PMC3812341

low Testosterone Estrogen Estradiol low T Testosterone hormone hormones CRP inflammation SHBG WBC men male

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • modest statistically significant inverse associations for total and calculated free testosterone, and modest positive associations for total and calculated free estradiol with CRP concentration
  • Estradiol concentrations were also weakly positively associated with WBC count
  • SHBG was weakly inversely associated with WBC
  • ...21 more annotations...
  • An association between testosterone and WBC count was not observed
  • These findings are consistent with the hypothesis that in men higher androgen concentration is anti-inflammatory, and higher estrogen concentration is pro-inflammatory.
  • the probability of elevated CRP concentrations (≥ 3 mg/L) decreased with higher total and calculated free testosterone concentrations, while the probability increased with higher total and calculated free estradiol concentrations
  • there is ample evidence supporting the immunosuppressive effect of androgens
  • The incidence of autoimmune diseases is higher in androgen-deficient men
  • Studies have shown that the induction of hypogonadism in older men is followed by a significant increase in IL-6 concentrations (Khosla et al. 2002), a potent stimulator of inflammation, and that activation of the androgen receptor exerts a direct anti-inflammatory effect
  • It has been suggested that the mechanisms for the immunosuppressive effect of androgens could be either a direct effect on the expression of inflammatory genes (Bellido et al. 1995; Asirvatham et al. 2006), or an indirect effect through inhibition of nuclear factor-kB activation
  • Estradiol is the major biologically active estrogen, and about 80% is formed in adult men from the aromatization of testosterone primarily in the adipose tissue
  • estrogen can stimulate the transcription factor C/EBP-β, which is involved in CRP transcription
  • Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers
  • A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration
  • Data from the Boston Area Community Health Survey also reported inverse associations between testosterone and CRP concentrations
  • Total testosterone was inversely associated with WBC count (Tang et al. 2007; Schneider et al. 2009; Brand et al. 2012), but calculated free testosterone was not associated with WBC
  • The first trial found a decrease in CRP, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα) but no changes in IL-6 and IL-10 concentrations between the active treatment and placebo arms
  • the majority of studies in the literature have not observed statistically significant associations between estradiol and inflammatory biomarkers in men, although several of them observed point estimates in the positive direction
  • total testosterone and estradiol compete for binding to SHBG, and seem to have opposite effects on the concentration of inflammatory biomarkers
  • A small randomized controlled trial of estrogen replacement therapy in prostate cancer patients showed an increase in CRP in the active treatment group versus the comparator group
  • Obese men are known to have lower androgen concentrations compared to their normal-weight counterparts
  • The strongest suggestion of an interaction was the inverse association between androstanediol glucuronide and CRP concentrations in obese participants, while the association was positive in the non-obese
  • A recent Chinese cross-sectional study observed stronger inverse associations between total testosterone and CRP concentrations in individuals with a BMI of 27.5 kg/m2 or greater
  • our results suggest that total and calculated free testosterone are modestly inversely associated with CRP concentrations, and that total and calculated free estradiol are modestly positively associated with CRP and WBC
  • Nathan Goodyear on 28 Apr 15
     
    Study results suggest that higher Testosterone and lower Estrogen levels provide anti-inflammatory effects in men.  The inflammatory biomarker assessed here was CRP.  Low total and calculated free Testosterone was associated with an increase in CRP.  In contrast, total and free Estrogen was associated with an increase in CRP.  Estradiol increased WBC count and SHBG was inversely related to WBC count in this study.
Nathan Goodyear

Human semen quality in the new millennium: a prospective cross-sectional popu... - 0 views

bmjopen.bmj.com/...e000990.full

men male infertility low sperm count concentration quality

shared by Nathan Goodyear on 29 Oct 12 - No Cached
  • Nathan Goodyear on 29 Oct 12
     
    2012 study that shows a slight uptick in sperm count/concentration in Danish men.  However, as the conclusion states, on 25% have optimal sperm quality.  When you look at the numbers deeper, the current general population sperm count/concentration was lower than that of men of infertile couples from 1940-1943 cohort.  Additionally, when the general population sperm count/concentration was lower than that of compared recent fertile men.
harshitatyagi

9 Ways to Boost Male Fertility & Increase Sperm Count - 0 views

crystaivf.com/...ility-and-increase-sperm-count

Male Fertility How to increase sperm count how to boost male fertility foods to increase sperm count

shared by harshitatyagi on 03 May 23 - No Cached
  • harshitatyagi on 03 May 23
     
    Research-based ways to boost male infertility and increase sperm count include various lifestyle changes, such as exercising regularly, Get enough vitamin C, Minimize your stress levels, Quit smoking and limit alcohol, Avoid toxic chemicals in the workplace, Eat more greens. Consider ashwagandha, Aim for a healthy weight, balance zinc levels, etc, Read the full blog.
Nathan Goodyear

The question of declining sperm density revisited: an analysis of 101 studies published... - 0 views

www.ncbi.nlm.nih.gov/...PMC1240129

sperm count men male fertility

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    Re-analysis of Carlsen's work on sperm count finds consistent decline in sperm count.  Swan and authors found a 1.5% decline in US men from 1934-1996 and 3% annual decline in European/Australian men over same time frame.  This was a meta-analysis of 101 studies from 1934-1996.  Yes, there is geographical variation, but the overall trend is one of decline.
Nathan Goodyear

Semen quality, infertility and mortality in the USA - 0 views

humrep.oxfordjournals.org/...humrep.deu106

infertility semen sperm mortality men male men's health health wellness

shared by Nathan Goodyear on 20 May 14 - No Cached
  • Nathan Goodyear on 20 May 14
     
    Men with infertility associated with 2.3 fold higher risk of death. The factors evaluated were semen volume, sperm concentration, sperm motility, total sperm count, total motile sperm count.  Those that have 2 or more positive parameters were associated with increased death compared to those with normal semen analysis.
Nathan Goodyear

High frequency of sub-optimal semen quality in an unselected population of young men - 0 views

humrep.oxfordjournals.org/...366.long

men male low sperm count quality infertility

shared by Nathan Goodyear on 29 Oct 12 - No Cached
  • Nathan Goodyear on 29 Oct 12
     
    Study found a large percentage, 40%, of young Danish men with low enough sperm count to predict infertility problems.
Nathan Goodyear

Evidence for decreasing quality of semen during past 50 years. - 0 views

www.ncbi.nlm.nih.gov/...PMC1883354

sperm count low T low testosterone men male hormone hormones

shared by Nathan Goodyear on 20 Oct 12 - No Cached
  • Nathan Goodyear on 20 Oct 12
     
    sperm count and quality have decreased significantly over last 50 years.  
Nathan Goodyear

Dog sperm quality decline is blamed on pet food chemicals | New Scientist - 0 views

www.newscientist.com/...s-blamed-on-pet-food-chemicals

sperm count low T low Testosterone environment EDC endocrine disrupting chemicals male fertility

shared by Nathan Goodyear on 10 Aug 16 - No Cached
  • Nathan Goodyear on 10 Aug 16
     
    26 year study of dogs finds declining sperm count equivalent to that in men.  The decline was found to occur at a rate of 1.2% to 2.5% annually over course of study.  The authors pointed to EDC's in food.
Nathan Goodyear

BMC Public Health | Full text | Decreasing sperm quality: a global problem? - 0 views

www.biomedcentral.com/...24

sperm count men infertility

shared by Nathan Goodyear on 22 Aug 12 - No Cached
  • Nathan Goodyear on 22 Aug 12
     
    Global downward trend in serum sperm count.
Nathan Goodyear

The impact of male overweight on semen quality and outcome of assisted reproduction Tho... - 0 views

www.ajandrology.com/article.asp

infertility BMI sperm count sperm concentration sperm motility

shared by Nathan Goodyear on 23 Sep 14 - No Cached
  • Nathan Goodyear on 23 Sep 14
     
    Abstract only. Study in men seeking reproductive assistance found that increasing BMI had no negative impact on sperm concentration, sperm count, motility and seminal volume. 
Nathan Goodyear

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240129/pdf/ehp0108-000961.pdf - 1 views

www.ncbi.nlm.nih.gov/...ehp0108-000961.pdf

sperm count men male hormone hormones sperm concentration

shared by Nathan Goodyear on 26 Jan 15 - No Cached
  • Nathan Goodyear on 26 Jan 15
     
    meta-analysis finds decline in sperm count.
Nathan Goodyear

Leptin Level and Oxidative Stress Contribute to Obesity-Induced Low Testosterone in Mur... - 0 views

www.hindawi.com/...190945

low T low Testosterone oxidative stress leptin hormone hormones obesity sperm count sperm motility

shared by Nathan Goodyear on 22 Oct 14 - No Cached
  • Nathan Goodyear on 22 Oct 14
     
    mouse study finds that increased oxidative stress and high leptin levels in obese mice led to decreased sperm count, decreased sperm motility, and low T.
Nathan Goodyear

https://academic.oup.com/DocumentLibrary/humupd/PR/dmx022_final.pdf - 0 views

academic.oup.com/...dmx022_final.pdf

male infertility sperm count infertility

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • Nathan Goodyear on 05 Mar 18
     
    The problem of male infertility continues to grow. New study finds that from 1973 to 2011, sperm count among men in North America, Europe, Australia, and New Zealand drop by 50-60%.
Nathan Goodyear

2292 MEDICAL TESTOSTERONE CAUSES IATROGENIC MALE INFERTILITY - A GROWING PROBLEM - 0 views

www.jurology.com/...fulltext

testosterone male infertility men hormone hormones treatment therapy

shared by Nathan Goodyear on 04 Jun 13 - No Cached
  • Nathan Goodyear on 04 Jun 13
     
    Indiscriminate use of testosterone in men can have irreversible effects.  This study showed that decreases sperm count, as a result of testosterone therapy in young men, can be irreversible.
Nathan Goodyear

Caffeine Intake and Semen Quality in a Population of 2,554 Young Danish Men - 0 views

aje.oxfordjournals.org/...883.abstract

coke soda sperm fertility men infertility

shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • Nathan Goodyear on 07 Jul 16
     
    high coke intake (defined as 1 L or greater) daily associated with lower sperm count and concentration.  
Nathan Goodyear

Effect of Cordyceps militaris supplementation ... [Am J Chin Med. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19051352

Cordyceps Cordyceps sinensis Testosterone Estradiol sperm

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    Cordyceps increased Testosterone, Estradiol, sperm count and motility in mouse model.
Nathan Goodyear

Long-term effect of ciprofloxacin on tes... [Int J Fertil Steril. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24520454

Testosterone cipro ciprofloxacin antibiotics infertility Leydig cells gonadotropins

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    mouse study finds that long-term cipro can lead to biochemical disruption of the testicles resulting in infertility, effected sperm counts, and decreased Testosterone.
Nathan Goodyear

Association between endogenous sex steroid hormone... [Andrology. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24124163

men aromatase estradiol estrogen inflammation CRP

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    Total and free Estradiol associated with increased CRP in men.  This study found that it also correlated with WBC count as well.   Not new, but builds on the accumulative literature that high aromatase activity and estrogen production in men produces inflammation.
Nathan Goodyear

Testosterone therapy in men with Crohn's disease improves the clinical course of the di... - 0 views

www.ncbi.nlm.nih.gov/...26020563

low T low Testosterone Crohn's Crohn's disease Testosterone hypogonadism inflammation CRP men male hormone hormones

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    men with Crohn's disease and low Testosterone found to benefit from Testosterone therapy without side effects.  There was a decrease in disease as determined by the Crohn's disease activity index, a decrease in CRP, and a decrease in leukocyte count.
Nathan Goodyear

Reversible infertility in male coeliac patients. - 0 views

www.ncbi.nlm.nih.gov/...PMC1681902

infertility male men hormone hormones celiac disease celiac disease gluten

shared by Nathan Goodyear on 28 Jul 14 - No Cached
  • Nathan Goodyear on 28 Jul 14
     
    Small study of 40 men with Celiac disease found to have improved sperm count and motility following elimination of gluten 
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