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Nathan Goodyear

Are antidepressants as effective as claimed... [Can J Psychiatry. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17375864

depression antidepressants Dr. Moncrieff SSRI

shared by Nathan Goodyear on 13 Jan 12 - No Cached
  • Nathan Goodyear on 13 Jan 12
     
    Editorial from Dr. Moncrieff.  The title of the editorial tells you everything you need to know.  
Nathan Goodyear

New test suggests antidepressant Paxil may promote breast cancer - latimes.com - 0 views

www.latimes.com/...ancer-20140218,0,3273056.story

paxil SSRI anti-depressants estrogen receptors breast cancer prostate

shared by Nathan Goodyear on 19 Feb 14 - No Cached
  • Nathan Goodyear on 19 Feb 14
     
    article on upcoming publication of study showing Paxil has estrogenic effect. Likely through receptors from paxil itself or metabolites.
Nathan Goodyear

Oral S-adenosylmethionine in depression: a randomi... [Am J Psychiatry. 1990] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...2183633

SAMe depression antidepressants

shared by Nathan Goodyear on 09 Dec 10 - No Cached
  • The results suggest that oral S-adenosylmethionine is a safe, effective antidepressant with few side effects and a rapid onset of action
  • Nathan Goodyear on 09 Dec 10
     
     100 studies show SAMe is as effective/more effective than anti-depressants; just one such study
Nathan Goodyear

Antidepressant Medication Use and Breast Cancer Risk - Am J Epidemiol - 0 views

aje.oxfordjournals.org/...951.abstract

anti antidepressant paxil breast cancer

shared by Nathan Goodyear on 08 Dec 10 - No Cached
  • Nathan Goodyear on 08 Dec 10
     
    Patients on paxil have a 7 fold increase breast cancer risk
Nathan Goodyear

The significance of proinflammatory cytokines and Th1/ Th2 balance in depression and ac... - 1 views

www.openaccessjournals.com/...action-of-antidepressants.html

inflammation depression

shared by Nathan Goodyear on 01 Nov 17 - No Cached
  • Nathan Goodyear on 01 Nov 17
     
    good review of the interatction between inflammation and depression and then the interaction between anti-depressants and inflammation
Nathan Goodyear

Comparative efficacy and tolerability of antidepressants for major depressive disorder ... - 0 views

www.thelancet.com/...abstract

depression anti-depressants children adolescents

shared by Nathan Goodyear on 09 Jun 16 - No Cached
  • Nathan Goodyear on 09 Jun 16
     
    could the anti-depressant industry in children and adolescents be a scam?  A review of the evidence finds very low quality of evidence with > 56% of the studies being funded by the industry itself; can you say conflict of interest or potential bias?  Review finds evidence only that fluoxetine is more effective than placebo in children and adolescents with depression.
Nathan Goodyear

Salivary testosterone: Associations with depression, anxiety disorders, and antidepress... - 0 views

www.jpsychores.com/...abstract

saliva salivary low testosterone depression anxiety mood disorders

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    large study revealed that low salivary testosterone is associated with increased depression, anxiety, and other mood disorders.
Nathan Goodyear

PsychiatryOnline | American Journal of Psychiatry | S-Adenosyl Methionine (SAMe) Augmen... - 0 views

ajp.psychiatryonline.org/article.aspx

SAMe SSRI depression major depression psychiatry

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    SAMe, in SSRI non-responders, resulted in a 46.1% response and a 35.8% remission compared to placebo.
Nathan Goodyear

Arch Gen Psychiatry -- Abstract: Trajectories of Depression Severity in Clinical Trials... - 0 views

archpsyc.ama-assn.org/...1227

depression psychiatry SSRI therapy treatment cymbalta duloxetine non-resonders

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    amazingly, up to 20% of patents with depression do worse on anti-depressant therapy (SSRI).  These are labeled non-responders, but when compared to placebo, the difference was significant.  Maybe, we should check their neurotransmitters first? 
Nathan Goodyear

Regulation of Adult Neurogenesis by Antidepressant Treatment - 0 views

www.nature.com/...1395801a.html

serotonin neurogenesis stress

shared by Nathan Goodyear on 08 Feb 12 - No Cached
  • Nathan Goodyear on 08 Feb 12
     
    serotonin shown to promote neurogenesis.  Stress shown to decrease neurogenesis.
Nathan Goodyear

America's State of Mind: New Report Finds Americans Increasingly Turn to Medications to... - 0 views

medco.mediaroom.com/index.php

antipsychotics medications america americans antidepressants antianxiety

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    Our current health care paradigm is failing us!  20% of women are on anti-depressants and 1 in 4 American women are on some psychiatric medicine.  And we wonder why we are unhealthy?
Nathan Goodyear

Effects of selective serotonin reuptake inhibitors o... [Thyroid. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19583486

thyroid SSRI antidepressants

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    Interesting study.  They found a "significant reduction of T(3) after 15 and 30 days" with SSRI use, yet their conclusion is SSRI is safe in hypothyroid.   The take is that part of the weight gain associated with SSRI use is through dysfunction of thyroid hormone production as the effects were also found with T4.
Nathan Goodyear

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3607061

carnitine L-Carnitine Acetyl-L-carnitine depression

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    rat model finds fast, long-lasting benefit of acetyl carnitine in depression.
Nathan Goodyear

In vivo and in vitro estrogenic activity of t... [Reprod Toxicol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22522098

SSRI fluoxetine estrogen antidepressants breast cancer hormones

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    SSRI, fluoxetine shown to increase "estrogenic response" in vitro and in vivo studies of breast cancer cell lines.
Nathan Goodyear

JAMA Network | JAMA | Antidepressant Drug Effects and Depression Severity:  A... - 0 views

jama.jamanetwork.com/article.aspx

depression anti-depressants

shared by Nathan Goodyear on 11 Nov 13 - No Cached
  • Nathan Goodyear on 11 Nov 13
     
    The benefits of anti-depressants in mild to moderate depression is no better than placebo.  However, in severe depression and with increasing severity, anti-depressants are better than placebo.
Nathan Goodyear

ScienceDirect - Journal of Psychiatric Research : Neuroendocrine effects of S-adenosyl-... - 0 views

www.sciencedirect.com/science

SAMe dopamine depression

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Our results, at least in depressed men, seem to support the hypothesis of a stimulating effect of SAMe on the dopaminergic system
  • Nathan Goodyear on 08 Mar 11
     
    SAMe stimulates dopamine secretion in depressed men
Nathan Goodyear

Serotonin transporter occupancy of five selective ... [Am J Psychiatry. 2004] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...15121647

SSRI serotonin transporter depression antidepressants

shared by Nathan Goodyear on 25 May 11 - No Cached
  • Nathan Goodyear on 25 May 11
     
    SSRI's and serotonin transporter effect
Nathan Goodyear

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4335177

hormones neurotransmitters serotonin GABA dopamine estradiol progesterone glutamate

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • estrogen administration has been found to increase tryptophan hydroxylase
  • 5-HT2A mRNA levels in brain areas relevant for the control of mood, mental state and cognition (Sumner and Fink, 1998) and 5-HTT mRNA when administered for a longer period
  • n the other hand, estrogen treatment has also been observed to decrease mRNA related to serotonergic neurotransmission
  • ...4 more annotations...
  • Furthermore, acute estrogen administration decreases 5-HTT mRNA levels (Pecins-Thompson et al., 1998) and 5-HT1A mRNA levels and binding
  • assigning the effects of estrogen on serotonin to a homogenous functional class of stimulation or inhibition seems not to be feasible
  • Progesterone has been suggested to increase serotonergic neurotransmission via the regulation of the expression of serotonin-related genes and proteins
  • menopausal women gain less benefit from antidepressant treatments compared to women during their reproductive years
  • Nathan Goodyear on 11 Jul 17
     
    good review of the relationship of the sex hormones and neurotransmitters.
Nathan Goodyear

Pharmacokinetics of oral and intravenous cannabidiol and its antidepressant-like effect... - 0 views

www.sciencedirect.com/...S1382668919300687

CBD cannabidiol depression Pharmacokinetics

shared by Nathan Goodyear on 28 Nov 22 - No Cached
  • Nathan Goodyear on 28 Nov 22
     
    CBD intravenous and oral pharmacokinetics
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