Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in ... - 0 views
www.ncbi.nlm.nih.gov/...PMC4560272
RIGVIR cancer oncolytic therapy immunotherapy cancer immunotherapy
shared by Nathan Goodyear on 16 Oct 18
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Rigvir is a 2 ml frozen solution
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ECHO-7 virus strain, Picornaviridae family, Enterovirus genus, Enteric Cytopathic Human Orphan (ECHO) type 7, group IV, positive-sense single-stranded RNA virus
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a few side effects were reported, for example subfebrile temperature (37.5°C for a couple of days), pain in the tumour area, sleepiness and diarrhoea
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In this retrospective study, however, there was no record of any untoward side effect from Rigvir treatment or its discontinuation
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Early observations of tumour regressions after virus infections have been published starting from the late 19th century
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The present results show that in substage IB, IIA, IIB and IIC melanoma patients, Rigvir administration after surgery significantly (P<0.05) prolongs survival compared with patients who were managed according to current published guidelines
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no value higher than grade 2 was recorded in Rigvir-treated patients. This is in contrast to most other cancer therapies, where grades 3 and 4 are frequently observed
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Administration of virus induces the formation of neutralising antibodies that might potentially influence the efficiency of Rigvir
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In 94 healthy adult participants tested, the titres were found to be low (1 : 20 to 1 : 62) 39,40. When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients
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the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults
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Rigvir is an immunomodulator that affects both the humoral, antibody-mediated, and the cellular immune systems
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it reduces the viability of melanoma, as well as pulmonary, gastric, pancreatic, bone, and breast cancer cell cultures