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Abstract only available, shows that polyphenols useful in the treatment of depression.

curcumin provides synergistic effect with zoloft in the treatment of major depression.

pubmed listing of 6,152 studies on benefits of curcumin.

Curcumin found to provide benefit even in the healthy. This study, though small and very short, found improvement in Triglycerides, salivary amylase, reduced oxidative stress, reduced beta-amyloid protein, increased NO, and reduced liver enzymes.

Good review of the research on curcumin.

Curcumin, at 2000 mg, found to be equal to 800 mg ibuprofen for osteoarthritis knee pain over 6 week study.

list of studies to review at later date of curcumin cognition

Curcumin consumption associated with increased cognition in elderly Asians.

TBI leaves the mitochondria of the brain compromised.  The result is a compromise in the ability to produce energy leaving the brain limited in its ability to heal and or handle additional insults.  This animal study found curcumin able to provide preservation of the energy pathways post TBI.  This has implications on any neuro-insult, not just TBI

Spice it up for cholesterol.  Study finds small, but significant, improvement in in HDL, LDL, and triglycerides with daily curcumin in those with metabolic syndrome.

curcumin found to be statistically similar to fluoxetine in depression;  In combination there is an adjuvant effect to increase the efficacy.

curcumin effective in inhibition of cancer and cancer stem cell activity through increasing apoptotic genes, affecting cellular signaling, altering growth factor receptors, microRNAs, tumor spheroid formation, and epithelial-mesenchymal transition; and found to be helpful in increasing chemo sensitivity to chemo and radiotherapy.

Only abstract available here.  Good discussion of the effects of curcumin: curcumin inhibits carcinogenesis, increases glutathione production, inhibits promotion and progression (mets) of cancer, induces cell apoptosis (cell death).