In this study, we have demonstrated microscopic pathology ranging from minimal to moderate in multiple different tissues previously reported to be involved with LD, including the nervous system (central and peripheral), heart, skeletal muscle, joint-associated tissues, and urinary bladder 12 to 13 months following tick-inoculation of rhesus macaques by Bb strain B31
Based on histomorphology, inflammation consisted predominantly of lymphocytes and plasma cells, with rare scattered histiocytes
in rare instances, morphologically intact spirochetes were observed in inflamed brain and heart tissue sections from doxycycline-treated animals
colocalization of the Bb 23S rRNA probe was not observed in any of the sections of experimental inoculated animals shown to harbor rare persistent spirochetes (Supplemental Figure S1). Previous in vitro work has shown large decreases in Bb rRNA levels when in a stationary phase of growth despite the majority of spirochetes remaining viable
The possibility that the spirochetes were intact but dead also exists, though this may be unlikely given the precedence for viable but non-cultivable B. burgdorferi post-treatment
The doxycycline dose utilized in this study (5mg/kg) was based on a previous pharmacokinetic analysis of oral doxycycline in rhesus macaques proven to be comparable to levels achieved in humans and was meant to mimic treatment of disseminated LD
In addition to the brain of two treated animals, rare morphologically intact spirochetes immunoreactive to OspA were observed in the heart of one treated animal
Although we did not measure the doxycycline levels in the cerebrospinal fluid, they have been found to be 12% to 15% of the amount measured in serum
We and others have demonstrated the development of a drug-tolerant persister population when B. burgdorferi are treated with antibiotics in vitro
The adoption of a dormant or slow-growing phenotype likely allows the spirochetes to survive and re-grow following removal of antibiotic
The basic premise that antibiotic tolerance may be an adaptation of the sophisticated stringent response required for the enzootic cycle by the spirochetes is described in a recent review as well
Although current IDSA guidelines recommend intravenous ceftriaxone (2g daily for 30 days) over oral doxycycline for treatment of neuroborreliosis, a randomized clinical trial failed to show any enhanced efficacy of I.V. penicillin G to oral doxycycline for treatment of Lyme neuroborreliosis (no treatment failures were reported in this study of 54 patients).
we can speculate that the minimal to moderate inflammation that was observed, especially within the CNS and PNS can, in part, explain the breadth of symptoms experienced by late stage Lyme disease patients, such as cognitive impairment and neuralgia.
Erythema migrans, the clinical hallmark of early localized Lyme disease, was observed in one of the rhesus macaques from this study.
In 2014, a trailblazing study in mice demonstrated a dramatic decline in B. burgdorferi DNA in the tissues for up to eight months after antibiotic treatment followed by the resurgence of B. burgdorferi growth 12 months after treatment
This study provides evidence that the slow-growing spirochetes which persist after treatment, but are not cultivable in standard growth media may remain viable.
The first well-documented indication of Lyme disease (LD) in the United States occurred in the early 1970s
Lyme, Connecticut.
Lyme disease is now known to be caused by multiple closely related genospecies classified within the Bb sensu lato complex, representing the most common tick-borne human disease in the Northern Hemisphere
approximately 30,000 physician-reported cases occur annually in the United States, the annual incidence has been estimated to be 10-fold higher by the Centers for Disease Control and Prevention.6
Current antibiotic therapy guidelines outlined by the Infectious Disease Society of America (IDSA) are successful in the treatment of LD for the majority of LD patients, especially when administered early in disease immediately following identification of erythema migrans (EM)
‘post-treatment Lyme disease syndrome’ (PTLDS)
host-adapted spirochetes that persist in the tissues, probably in small numbers, inaccessible or impervious to antibiotic
inflammatory responses to residual antigens from dead organisms
residual tissue damage following pathogen clearance;
autoimmune responses, possibly elicited by antigenic mimicry
Experimental studies on immunocompetent mice, dogs, and rhesus macaques have provided evidence for the persistence of Bb spirochetes subsequent to antibiotic treatment in the form of residual spirochetes detected within tissue by IFA and PCR, and recovered by xenodiagnoses
Ten male rhesus macaques
half (five) of the NHP received antibiotic treatment, consisting of 5 mg/kg oral doxycycline twice per day.
Minimal and focal lymphoplasmacytic inflammation
inflammation was observed in the leptomeninges overlying a section of temporal cerebral cortex
Minimal localized lymphoplasmacytic choroiditis
Peripheral nerves contained minimal to moderate lymphoplasmacytic inflammation with a predilection for collagen-rich epineurium and perivascular spaces
Inflammation was observed in 56% (5/9) of the NHPs irrespective of treatment group
For all animals, inflammation was reserved to perineural tissue
The treatment lasted 28 days
Minimal to mild lymphoplasmacytic inflammation of either the myocardial interstitium (Figure 2Figure 2A), pericardium (Figure 2Figure 2B), or combination therein was observed in 60% of NHPs
A single morphologically intact spirochete, as indicated by positive red immunofluorescence (Figure 2Figure 2C), was observed in the myocardium of one treated animal
mild, multifocal lymphoplasmacytic inflammation was observed in one doxycycline-treated animal
three animals exhibited minimal to mild lymphoplasmacytic inflammation affecting joint-associated structures
10% to -20% of human patients treated
Multiple randomized placebo-controlled studies which evaluated sustained antimicrobial therapy concluded that there is no benefit in alleviating patients’ symptoms and indicated that long-term antibiotic therapy may even be detrimental to patients due to potential associated complications (ie, catheter infection and/or clostridial colitis)
and the rapid clearance of dead spirochetes in a murine model
higher doses may be needed to combat neuroborreliosis
persistent borrelia burgdorferia were found in the brain (2) and the heart (1) up to 13 months post standard antibiotic treatment suggesting borrelia burdorferia, the cause of Lyme, can persist in a chronic, persistant state poste acute treatment.
TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
liver protective action of TA-65
A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
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play a role during the initial chemotactic response of neutrophils shortly after infection
following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
also contributes to the phagocytosis and killing of microbes by neutrophils
low levels of vitamin C occurring in high-stress situations
maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
Vitamin C has been shown to directly affect the number of Igs released from B cells
vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
vitamin C also acts as an important antioxidant to the cells of the immune system.
human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
vitamin C can decrease the activation of NF-kB
can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic
subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
hydroxylating proline and lysine
mature and stabilize the tissue of a healing wound
healing
oral surgery
improved soft tissue regeneration
vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
8 g doses of oral vitamin C
there is a negative correlation between age and serum levels of vitamin C
Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
Flawed statement. What is normal? Vitamin D.
Many variables effect levels and dose, including the two compartment kinetics and absorption.
Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
linear relationship between days of vitamin C therapy and survival duration
other studies were unable to find any definitive improvement concerning therapy with vitamin C
Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
They are kind of make the point from my earlier note.
continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
Again, designed to fail or ignorance designed the study which failed
Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
reduced overall mortality
reduced overall mortality
propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
This study of 116 patients diagnosed with ADHD, found that 80% could achieve improvement or "ameliorate" ADHD symptoms with supplementation with minerals, vitamins, amino acids, and essential fatty acids. I too have seen this in my practice. Maybe ADD/ADHD is simply a gut/dietary problem manifested in the brains of our children. That we treat with powerful drugs, that simply can be treated with dietary change
Every child loves Halloween. It's always a fun time to go out in costume and get treats. If they are lucky they are bound to take home a bag full of candy. That is always good for the kids, but bad for their dental health. Taking care of children's dental health can already be a challenge for some without the constant temptation of sweets.
Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase. The VISP trial did not show efficacy in the intention to treat analysis. However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.
The adjusted post/pre RR for PDE5I across all ages was 1.08
For TT prescription, in men under age 65 years, the RR was 2.90 (1.49, 5.62) for those with a history of heart disease and 0.90 (0.61, 1.34) for those without
In men aged 65 year and older, the RR was 2.16 (0.92, 5.10) for those with a history of heart disease and 2.21 (1.09, 4.45) for those without.
Among men aged 65 years and older, we observed a two-fold increase in the risk of MI in the 90 days after filling an initial TT prescription
Among younger men with a history of heart disease, we observed a two to three-fold increased risk of MI in the 90 days following an initial TT prescription and no excess risk in younger men without such a history
Among older men, the two-fold increased risk was associated with TT prescription regardless of cardiovascular disease history
our own findings appear consistent with a higher frequency of thrombotic events following TT prescription among men with more extensive coronary vascular disease.
Our findings are consistent with a recent meta-analysis of placebo-controlled randomized trials of testosterone therapy lasting 12 or more weeks among mainly older men, which reported that testosterone therapy increased the risk of adverse cardiovascular-related events (OR = 1.54, 95%CI:1.09, 2.18), as well as serious adverse cardiovascular-related events (OR = 1.61, 95%CI:1.01, 2.56) which included myocardial infarction along with other conditions
This association appeared unrelated to average baseline testosterone level (p = 0.70) but varied by source of funding (p = 0.03), with a stronger summary effect in a meta-analysis of studies not funded by the pharmaceutical industry (OR = 2.06, 95%CI:1.34, 3.17) compared with studies funded by the pharmaceutical industry
This supports prior analysis that studies done by pharmaceutical corps will be more favorable to their product(s) than those independently funded. This is called bias.
the evidence supports an association between testosterone therapy and risk of serious, adverse cardiovascular-related events–including non-fatal myocardial infarction–in men
there is some evidence that low endogenous testosterone levels may also be positively associated with cardiovascular events
effects of endogenous and exogenous testosterone may differ. Exogenous testosterone (TT) is associated with physiologic changes that predispose to clotting and thrombotic disorders including increased blood pressure [18], polycythemia [19], reductions in HDL cholesterol [18], [20], and hyperviscosity of the blood and platelet aggregation. [20]–[23]; TT also increases circulating estrogens [24], [25] which may play a role in the observed excess of adverse cardiovascular-related events, given that estrogen therapy has been associated with this excess in both men and women
did not include information on the serologic or diagnostic indications for treatment.
no association between PDE5I prescriptions and the risk of MI
Recently TT has been increasing extraordinarily rapidly, including among younger men and among those without hormone measurement
Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
Testosterone acts as a calcium channel blocker inducing vasodilation.
men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
Exercise capacity in men with chronic heart failure increased after 12 weeks
Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
Hypogonadism is a common feature of the metabolic syndrome
The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
levels of testosterone are reduced in proportion to degree of obesity
Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
Testosterone increases levels of fast-twitch muscle fibres
By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
Weight loss will increase levels of testosterone
studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
There is high level evidence that TRT improves insulin resistance
Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% (
) in the treated group with the greatest effect in younger men and those with type 2 diabetes
the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
inverse associations between low TT or FT (Table 2) and the severity of CAD
A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
TDS is associated with increased cardiovascular and all-cause mortality
The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
hypogonadal men had slightly increased triglycerides and HDL
Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls (
) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
TRT has also been shown to reduce fibrinogen to levels similar to fibrates
men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
Low androgen levels are associated with an increase in inflammatory markers
A decline was noted in IL6 and TNF-alpha
In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
What about just starting with normalization of Testosterone levels first.
Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
Ergo Wheelchair features an ergonomic "S" shaped seat that provides the perfect shape to fit the human body to relieve pressure, increase stabilization, weight distribution and lower the risk of pressure sores and scoliosis. Ergonomic wheelchair series provides users with a large selection of ultra lightweight wheelchairs that can help improve life. This series has features that include a high strength lightweight frame, foldable and easy to store, breathable anti-bacterial, anti-staining, removable and machine washable cushion. Also includes the exclusive S-Shape Seating System, which provides increased stability, better weight distribution and lowers the risk of pressure sores and spinal injury.
Karma S Ergo 115 Wheelchair:
This model features our S-Shape Seating System and is our number one best seller for many reasons. At a mere 11.3 kg in weight with detachable foot rest and many features such as removable machine washable and dry-able cushions treated by AEIGIS treated anti-microbial coated seating system.
Karma S-Ergo 115 Wheelchair Features:
Ergonomic Handrims & S-Shape Ergonomic Seating System
Fixed armrest w/ wider concave armpads
Swing In & Away Footrests
Backrest Pouch attached to the upholstery
24" flat free polyurethane tires, high tread, flat free wheels
Seat width: 16"x17" or 18"x17" or 20"x 17"
Silver 1/4" Aegis Anti-Bacterial Upholstery, washable
Folding backrest / folding seat for easy traveling
"Tube-in Center" foot-plate, assures better side leg support
High strength, starting weight at only 11.3 kg. (w/o footrests)
7×1" Polyurethane front casters
Upholstery: Black breathable mesh bottom & top AEIGIS
Frame Color: Pearl Silver or Rose Red
Weight Capacity of 115 kg.
Karma S-Ergo 115 Wheelchair Measurements:
Seat Width 16 inch., 18 inch., 20 inch.
Seat Depth 17 inch.
Armrest Height 8 inch.
Seat Height 19 inch.
Back Height 17 inch.
Overall Height 36 inch.
Overall Open Width 23 inch., 25 inch., 27 inch
Case study of 3 patients with Pancreatic cancer treated with IV alpha lipoic acid and LDN therapy. This is a f/u to a patient treated and still living--case study published in '06. Only, the abstract is currently available to the general public.
Net neutrality is one of the biggest issue debated globally by the telecom regulators and it is also in the process of finalising what will be a landmark recommendation for Indian telecom.
The important aspects of Net neutrality are:
Internet service providers should enable access to all content and applications regardless of the source.
The Internet service provider from whom buy internet pack, should not under any circumstance be able to control how exactly use it and it's upto how you use the data.
All websites can co-exist without hampering others and all websites are accessible at the same speed and no particular website of application is favoured.
All web sites and content creators are treated equal, and it don't have to pay extra for faster Internet speed to a particular site/service.
The concept of net neutrality doesn't exist legally but most companies have Net Neutrality is simply the Internet Freedom - Free, Fast and Open Internet for all. Net Neutrality is the principle that Internet service providers (ISPs) should give consumers access to all and every contents and application on an equal basis, treating all Internet traffic equally.
Today, if there's something that makes everyone across the world "Equal" is nothing but the Internet. Equality over the Internet means, the richest man in the world has the same rights to access the Internet as the poorer. And this is what "Net Neutrality" aims at adhered to it until now. With the Internet taking the world into its folds, Internet Service Providers across the world are trying to encash this potent commodity and trying to control the traffic.
Karma Healthcare KP-80 Standing Wheelchair is a compact and fully powered wheelchair designed for budget. The front-wheel drive provides agile control for the chair to negotiate various indoors and out. It comes with the innovative seat and wide range of power backrest angle adjustment (80~120 degree).
Ergonomic wheelchair series provides users with a large selection of ultra lightweight wheelchairs that can help improve life. This series has features that include a high strength lightweight frame, foldable and easy to store, breathable anti-bacterial, anti-staining, removable and machine washable cushion. Also includes the exclusive S-Shape Seating System, which provides increased stability, better weight distribution and lowers the risk of pressure sores and spinal injury. The patented S-Shape Seating System that comes with every wheelchair model in this series provides an ergonomic seating frame that conforms and flexes to the shape of body.
Karma S Ergo 115 Wheelchair:
This model features our S-Shape Seating System and is our number one best seller for many reasons. At a mere 11.3 kg in weight with detachable foot rest and many features such as removable machine washable and dry-able cushions treated by AEIGIS treated anti-microbial coated seating system.
Karma S-Ergo 115 Wheelchair Features:
Ergonomic Handrims & S-Shape Ergonomic Seating System
Fixed armrest w/ wider concave armpads
Swing In & Away Footrests
Backrest Pouch attached to the upholstery
24" flat free polyurethane tires, high tread, flat free wheels
Seat width: 16"x17" or 18"x17" or 20"x 17"
Silver 1/4" Aegis Anti-Bacterial Upholstery, washable
Folding backrest / folding seat for easy traveling
"Tube-in Center" foot-plate, assures better side leg support
High strength, starting weight at only 11.3 kg. (w/o footrests)
7×1" Polyurethane front casters
Upholstery: Black breathable mesh bottom & top AEIGIS
Frame Color: Pearl Silver or Rose Red
Weight Capacity of 115 kg.
Karma S-Ergo 115 Wheelchair Measurements:
Seat Width 16 inch., 18 inch., 20 inch.
Seat Depth 17 inch.
Armrest Height 8 inch.
Seat Height 19 inch.
Back Height 17 inch.
Overall Height 36 inch.
Overall Open Width 23 inch., 25 inch., 27 inch.
Folded Width 12 inch.
Overall Length 39 i
Ergonomic wheelchairs have been tested and proven to be effective for relieving pressure throughout the body; this is confirmed by pressure chart mapping. Feeling comfortable on a wheelchair is something every user demands out of their new wheelchair, the ergonomic cushion that is included with the ergonomic series provides a level of comfort that is unparalleled. Ergonomic Transport Wheelchair provides the perfect shape to fit the human body to relieve pressure, increase stabilization, weight distribution and lower the risk of pressure sores and scoliosis. Lightweight Ergonomic Wheelchair features wide arm pads for extra support, folding back rest, detachable swing-away footrests, and a Tube-in Center foot-plate that provides extra support for the leg muscles.
This wheelchair can hold up to daily use and is excellent for traveling. Ergonomic features flip-back armrest and swing away footrests. A lightweight frame that is 25 lbs. without footrests and a folding backrest allows easy travel or storage. The chair comes equipped with a padded anti-bacterial upholstery that is comfortable and washable.
Karma Ergo Lite 2501 Wheelchair:
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Despite its light weight, the S-Ergo features a 115 kg. weight capacity along with large, 14" flat-free polyurethane rear tires.
Karma Ergo Lite 2501 Wheelchair Features:
Lightest transporter on the market!
Patented S-Style Ergonomic Seat Frame
6061 T-6 Aircraft-grade Aluminum Only 18 lb . (w/ footrests)
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Pocket Behind Backrest & Small Carry Pouch on Each Armrest
6" x 1" Polyurethane
Percent survival at 1 year was significantly increased in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05) in study which suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates
What causes nausea and how can you avoid/treat it at home? You feel nauseous when your stomach either stops contracting or... Ever wonder why you feel so uneasy while driving across a rough, bumpy road? How does nervousness lead to nausea? Patients with nausea make up 6.7% of all cases treated...
Today was an exceptionally bright day. At least the morning. The rest of the day was marred by Kate throwing up on me nonstop. She felt a strong sensation of nausea and dizziness. But why does she eat at that weird Mexican place when she knows it makes her stomach sick? Every time she goes there, she feels a gut-wrenching, stomach-turning urge to release all that her belly holds. I mean, the stomach is an elastic bag made of muscular walls containing acid. We read that in science once. But why does Kate's stomach hold a serious grudge against Mexican food?
The SOC for GBM was modified in this patient to initiate KMT prior to surgical resection, to eliminate steroid medication, and to include HBOT as part of the therapy
the greatest therapeutic benefit for patients (near 1.0)
The observed reduction in blood glucose in our patient would reduce lactic acid fermentation in the tumor cells, while the elevation of ketone bodies would fuel normal cells thus protecting them from hypoglycemia and oxidative stress
Previous studies showed that GBM survival and tumor growth was correlated with blood glucose levels
Evidence indicates that glioma cells cannot effectively use ketone bodies for energy due to defects in the number, structure, and function of their mitochondria
The accuracy of the GKI as a predictor for therapeutic efficacy, however, is better when ketone bodies are measured from the blood than when measured from the urine
A reduction of glucose-driven lactic acid fermentation would not only increase tumor cell apoptosis, but would also reduce inflammation and edema in the tumor microenvironment thus reducing tumor cell angiogenesis and invasion
Besides serving as a metabolic fuel for GBM, glutamine is also an essential metabolite for normal immune cells
therapies that inhibit glutamine availability and utilization must be strategically employed to avoid inadvertent impairment of immune cell functions
we used the non-toxic green tea extract, EGCG, and chloroquine in an attempt to limit glutamine availability to the tumor cells
EGCG is thought to target the glutamate dehydrogenase activity that facilitates glutamine metabolism in GBM cells
Chloroquine, on the other hand, will inhibit lysosomal digestion thus restricting fermentable amino acids and carbohydrates from phagocytosed materials in the tumor microenvironment
HBOT to increase oxidative stress in the tumor cells
As glucose and glutamine fermentation protect tumor cells from oxidative stress, reduced availability of these metabolites under ketosis could enhance the therapeutic action of HBOT, as we recently described
Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast
Following the fast, the patient initiated a vitamin/mineral-supplemented ketogenic diet (KD) for 21 days that delivered 900 kcal/day
KD (increased to 1,500 kcal/day at day 22
the patient received metformin (1,000 mg/day), methylfolate (1,000 mg/day), chloroquine phosphate (150 mg/day), epigallocatechin gallate (400 mg/day), and hyperbaric oxygen therapy (HBOT) (60 min/session, 5 sessions/week at 2.5 ATA)
Biomarkers showed reduced blood glucose and elevated levels of urinary ketones with evidence of reduced metabolic activity (choline/N-acetylaspartate ratio) and normalized levels of insulin, triglycerides, and vitamin D
This is the first report of confirmed GBM treated with a modified SOC together with KMT and HBOT, and other targeted metabolic therapies
Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers
less than 20% of younger adults generally survive beyond 24 months
glucose and glutamine are the primary fuels that drive the rapid growth of most tumors including GBM
Glucose drives tumor growth through aerobic fermentation (Warburg effect), while glutamine drives tumor growth through glutaminolysis
The fermentation waste products of these molecules, i.e., lactic acid and succinic acid, respectively, acidify the tumor microenvironment thus contributing further to tumor progression
Glucose and glutamine metabolism is also responsible for the high antioxidant capacity of the tumor cells thus making them resistant to chemo- and radiotherapies
The reliance on glucose and glutamine for tumor cell malignancy comes largely from the documented defects in the number, structure, and function of mitochondria and mitochondrial-associated membranes
These abnormalities cause the neoplastic GBM cells to rely more heavily on substrate level phosphorylation than on oxidative phosphorylation for energy
dexamethasone not only increases blood glucose levels but also increases glutamine levels through its induction of glutamine synthetase activity
Calorie restriction and restricted KD are anti-angiogenic, anti-inflammatory, anti-invasive, and also kill tumor cells through a proapoptotic mechanism
Evidence also shows that therapeutic ketosis can act synergistically with several drugs and procedures to enhance cancer management improving both progression free and overall survival
hyperbaric oxygen therapy (HBOT) increases oxidative stress on tumor cells especially when used alongside therapies that reduce blood glucose and raise blood ketones
The glutamine dehydrogenase inhibitor, epigallocatechin gallate (EGCG) is also proposed to target glutamine metabolism
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Good place to start on the understanding, yet oversimplified. The dosage has to be individually determined based on tumor burden, body size...A one size fits all approach never works. One cannot simple treat statistics; but, instead, must treat people...which are not statistics.