Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in t... - 0 views
www.jneurosci.org/...12312.long
Testosterone polyneuropathy MS multiple Sclerosis Estriol hormones autoimmune disease
shared by Nathan Goodyear on 17 Mar 15
- No Cached
-
direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
-
Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
- ...7 more annotations...
-
This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
-
treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
-
estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
-
Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
-
MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
-
In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI