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Appendicitis: Causes, Symptoms and Treatment | Health Blog - 0 views

fnfdoc.com/...itis-causes-symptoms-treatment

Appendicitis Causes Symptoms Treatment Types Appendix Pain

shared by fnfdoc on 02 Jul 18 - No Cached
  • fnfdoc on 02 Jul 18
     
    What Is Appendicitis? How to diagnose Appendicitis? Where is Appendix pain located In this article, we hope you can find all of your answers related to Appendicitis. We covered everything about Appendicitis. We discussed types, causes, symptoms, tests, and treatment of Appendicitis.
  • fnfdoc on 02 Jul 18
     
    Appendicitis is an inflammation of the appendix, which is a small tube of intestinal tissue that projects from the large intestine. While the appendix does not seem to have a particular function, one theory suggests that it acts as a storehouse of good bacteria and boosts immunity after diarrheal illness. However, some experts believe the appendix is just a purposeless remnant from our evolutionary past. One thing we're sure of is that we can live without it, without any apparent consequences.
Nathan Goodyear

International Tables of Glycemic Index and Glycemic Load Values: 2008 - 1 views

www.ncbi.nlm.nih.gov/...PMC2584181

glycemic index load

shared by Nathan Goodyear on 16 Aug 13 - No Cached
  • Nathan Goodyear on 16 Aug 13
     
    Great article from 2008 that discusses glycemic index and glycemic load.  What is great about this article is the supplementary appendix listing the above for > 1000 items.
Nathan Goodyear

Inhibitory Effect of Progesterone on Inflammatory Factors after Experimental Traumatic ... - 0 views

211.167.248.24/...2007-20-5-15.pdf

progesterone inflammation anti-inflammatory TBI traumatic brain injury NF-kapppB

shared by Nathan Goodyear on 29 May 12 - No Cached
  • Nathan Goodyear on 29 May 12
     
    Now, this is in a rat TBI model; but progesterone was shown to reduce the inflammatory response post TBI. Particularily, through NF-kappa B inhibition.
Nathan Goodyear

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine | PNAS - 0 views

www.pnas.org/10238

AML leukemia acute myeloid leukemia MDS vitamin C cancer

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Vitamin C alone at concentrations up to 57 μM had little effect on cell growth but was toxic at 228 μM (SI Appendix, Fig. S1B), in line with recent studies of high vitamin C concentrations (125–2,000 μM)
  • In our combination approach, vitamin C increased the effects of low doses of 5-aza-CdR, with 57 μM vitamin C almost doubling the growth inhibition
  • Using the Chou–Talalay method (28), we found that the two compounds indeed acted synergistically, rather than additively, to inhibit cancer cell growth over the physiological ranges of vitamin C in healthy individuals (26–84 μM)
  • ...12 more annotations...
  • These results show that targeting the cancer DNA methylome by combining low-dose 5-aza-CdR and vitamin C stimulates the expression of ERVs, the induction of a cell-autonomous immune activation response, and increased apoptosis of cancer cells
  • The addition of vitamin C to treatment protocols therefore may be a straightforward way to increase the clinical efficacy of such drugs in MDS and leukemia patients
  • Vitamin C deficiency has been seen previously in patients with multiple types of cancer, including hematological malignancies (35⇓–37). We predict that these patients might receive the most benefits from the combination treatment.
  • induction of an innate immune response
  • We therefore measured plasma concentrations of vitamin C in a small number of patients with miscellaneous hematologic malignancies. Strikingly, 58% of patients with hematological neoplasia who were not taking vitamin C supplements had severe vitamin C deficiency (serum concentration <11.4 μM, at which clinical features of scurvy may be manifested) (34), and 33% had vitamin C levels below the normal range
  • it is possible that vitamin C was oxidized to DHA before it was transported into the cells
  • Oral administration of vitamin C should be sufficient for the therapeutic strategy, because the concentrations reported in this study would not require i.v. administration.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 18
       
      This statement lacks a basic understanding of vitamin C pharmacokinetics.
  • Vitamin C is an essential nutrient for humans and has been reported to increase IFN levels in human cells upon virus infection
  • daily treatment with vitamin C alone at physiological concentrations enhanced the expression of viral-defense genes relative to untreated cells
  • When combined with low-dose 5-aza-CdR, physiological concentrations of vitamin C synergistically inhibited cancer-cell growth and induced apoptosis. Such synergy was associated with increased ERV expression and dsRNA in treated cells. The mechanism of action differs from that of vitamin C at higher doses, which involves its pro-oxidant activity, including GSH inhibition, to generate reactive oxygen species
  • This activity has been shown to induce DNA damage and to enhance the sensitivities of myeloid malignancies, multiple myeloma, and cutaneous T-cell lymphoma to arsenic trioxide (41⇓⇓–44). It also can increase chemosensitivity of ovarian cancer cells (27) and selectively kill KRAS or BRAF mutant colorectal cancer cells by inhibiting GAPDH
  • reactive oxygen species
  • Nathan Goodyear on 12 May 18
     
    91% of patients with hematologic malignancies have vitamin C levels that are either low or severly deficient. This study found that vitamin C plus low dose DNA methyltransferase inhibitors have synergistic inhibition of cancer cell proliferation and increased apoptosis.  Unfortunately, the authors claimed that oral vitamin C would be sufficient which indicates an incredible lack of understanding of vitamin C pharmacokinetics.
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