Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treat... - 0 views
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Experimental animal studies have shown that Borrelia burgdorferi, the agent of Lyme borreliosis, consistently establishes persistent infections in a variety of immunocompetent hosts, including laboratory mice [1], white-footed mice (Peromyscus leucopus) [2], [3], [4], rats [5], hamsters [6], guinea pigs [7], gerbils [8], dogs [9], and nonhuman primates, including rhesus macaques (Macaca mulatta) [10] and baboons (Papio spp.
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With the advent of PCR, and more recently real-time quantitative PCR (qPCR), which offers greater sensitivity and specificity, B. burgdorferi-specific DNA has been found to persist for months following antibiotic treatment in tissues of experimentally infected mice [14], [15], [16], [17], [18], [19], [20], dogs [9], [21] and macaques [22], as well as humans
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In addition, intact spirochetes have been demonstrated by immunohistochemistry in connective tissue of culture-negative treated mice and within ticks that fed upon them [15], [17] as well as in tissues of and ticks that fed upon treated macaques
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mouse model using ceftriaxone treatment regimen found that non-cultivatable B. burgdorferia persisted 8+ months post treatment and there was an increase in B. burgdorferi DNA in multiple sites at 12 months.
