Estradiol in mice predisposed to Lupus have increased inflammation and characteristics of Lupus. In contrast, Estradiol in those without predisposition, do not. Clearly this is an inflammatory signaling problem. Studies have shown an Interferon gamma signaling deficit in those with Lupus.
Testosterone decreases the above inflammation signaling.
SLE or Lupus is an autoimmune disease that causes inflammation of the organs and swelling of the joints. It has vast effects on the renal, skeletal, gastrointestinal and blood systems. It affects mostly people of Chinese and African origin and presents in a capricious and unpredictable manner.
Vitamin D support provides benefit in those with Lupus. The proposed mechanism is through the balance of Treg cells and Th17 cells. This imbalance plays a role in the etiology of autoimmune disease and those with autoimmune disease, such as in Lupus, frequently have low vitamin D levels.
good review of sex hormones and LUPUS; whether it is causative or not, sex hormones trends exist in LUPUS i.e. low DHEA in both sexes, low progesterone in women, and low Testosterone in women>men.
The purpose of this post is not that prednisone should be used to improve the fatty acid profile in those with Lupus. That is ridiculous. But, that fatty acid abnormalities are consistently found in Lupus and particularly omega-3 fatty acids should be evaluated.
low EPA and DHA found in patients with Lupus. The authors of this article went so far as to say that lipid peroxides, NO, and anti-oxidants should be a part of the work up for patients with Lupus.
low Progesterone and progesterone "disturbances" found to be common in juvenile Lupus. The authors in this study proposed it was due to low follicular reserves. The point is that low progesterone increases inflammatory cytokines.
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