SHBG decreased in hyperinsulinemic states, such as in metabolic syndrome. Low Testosterone has proven to be the same, though not looked at in this study.
Also, in this study, low SHBG is associated with increased cardiovascular mortality.
low grade, chronic inflammation associated with PCOS and common disease states associated with PCOS. It is known that high androgen levels in women causes inflammation.
editorial discussion of the benefit of vitamin D in mitochondrial function. Those in the vitamin D repletion arm of the study had a quicker recovery time to restored phospho-creatinine levels. The quicker the recovery of phospho-creatinine levels, the shorter recovery phase and the likely improvement in athletic performance.
Fascinating link between vitamin D and mitochondria function in skeletal muscle. Vitamin D replacement was found to improve mitochondrial function, improve post exercise discomfort in those with vitamin D deficiency. Obviously, this provides support for a link between vitamin D and mitochondrial function. This could provide an important tool in the recovery phase in athletes.
Age seems to predict metabolism of testosterone in those receiving testosterone therapy. Older men appear to have slower metabolism of testosterone. This implies that one can likely dose "older" men at lower dosages.
Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction. This study even showed that BPA inhibited thyroid receptor transcription.
This study they looked at the withdrawal of cortisol on glucose homeostasis. The point is that cortisol has profound effects on glucose homeostasis. Elevated cortisol or exogenous intake reduces T3 and increases insulin resistance.
Metformin shown to suppress TSH secretion without change in free t4 or free t3 levels. This again, shows the lack of reliability of the test TSH. With the suppression of TSH indicated in this study, the free t4 and t3 should have been elevated, but were obviously not.
study finds no increased risk of CHD, HF, or CV death in subclinical hypothyroidism in older adults. No insight is gained from this article, due to the use of TSH as the only tool for thyroid assessment. TSH has been shown to become unreliable as a sole thyroid assessment tool an aging population.
Insulin therapy in people with type II diabetes shown to increase complications, cancer, and mortality. The reason? Insulin is not the problem. Treat the cause. Diabetes can not be properly managed without dietary changes and weight loss.