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Nathan Goodyear

Salinomycin as a Drug for Targeting Human Cancer Stem Cells - 0 views

www.ncbi.nlm.nih.gov/...PMC3516046

CSC cancer cancer stem cells salinomycin

shared by Nathan Goodyear on 27 Apr 21 - No Cached
  • Nathan Goodyear on 27 Apr 21
     
    To be read
Nathan Goodyear

Radiation‐Induced Reprogramming of Breast Cancer Cells - Lagadec - 2012 - STE... - 0 views

stemcellsjournals.onlinelibrary.wiley.com/...stem.1058

CSC cancer radiation cancer stem cells

shared by Nathan Goodyear on 07 May 21 - No Cached
  • Nathan Goodyear on 07 May 21
     
    ionizing radiation increased the number of BCSCs in the overall breast cancer cell population
Nathan Goodyear

Type 3 Deiodinase: Role in Cancer Growth, Stemness, and Metabolism - 0 views

www.ncbi.nlm.nih.gov/...PMC4269192

rT3 reverse T3 HIF-1alpha CSC deiodinase D3 cancer stem cells cancer

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    Amazing article. Increased deiodinase 3 activity in cancer increases rT3 production. What drives the increase in deiodinase 3?
Nathan Goodyear

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience - 0 views

www.ncbi.nlm.nih.gov/...PMC6446118

cancer therapy HIF-1alpha metastasis CSC metronomic chemotherapy cancer stem cells cancer treatment VEGF angiogenesis

shared by Nathan Goodyear on 06 Aug 20 - No Cached
  • Nathan Goodyear on 06 Aug 20
     
    Awesome article on how metronomic, low-dose chemotherapy reduces angiogenesis via decrease in HIF-1alpha and VEGF. Many other effects.
Nathan Goodyear

Function of oncogenes in cancer development: a changing paradigm - 0 views

www.ncbi.nlm.nih.gov/...PMC3671260

cancer stem cells CSC cancer epigenetics oncogenes

shared by Nathan Goodyear on 05 Jun 20 - No Cached
  • Nathan Goodyear on 05 Jun 20
     
    to be read
Nathan Goodyear

Redox regulation in cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC2835886

estrogen cancer stem cells reaction" CSC hormones cancer Redox

shared by Nathan Goodyear on 08 Nov 18 - No Cached
  • Mitochondrial electron-transport chain and other oxidizing agents are the prime pathways that generate excess ROS in vivo
  • Permanent modification of genetic material resulting from the oxidative damage is one of the vital steps involved in mutagenesis that leads to carcinogenesi
  • The most frequent DNA mutations caused during oxidative stress, initiated by ionizing radiation and other environmental carcinogens are 7,8-dihydro-8-oxoguanine (8-Oxo-G) and Thymine Glycol (TG)
  • ...3 more annotations...
  • catalase and SOD, GPx, GST
  • insulin like growth factor I, or fibroblast growth factor 2 generates ROS
  • Depletion of GSH increases the sensitivity of cells to ROS
  • Nathan Goodyear on 08 Nov 18
     
    The redox reaction in cancer: great read!
Nathan Goodyear

Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Co... - 0 views

pubmed.ncbi.nlm.nih.gov/33419797

colon cancer peptides cancer CSC PNC-27 cancer stem cells PNC27

shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 selectively kills colon cancer stem cells by binding to membrane H/MDM-2. This was an in vivo study. As with other studies, the result was tumor cell necrosis and associated high LDH release.
Nathan Goodyear

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer ... - 0 views

pubmed.ncbi.nlm.nih.gov/30688660

cancer stem cells breast cancer CSC LDH lactate dehydrogenase stress cancer epinephrine

shared by Nathan Goodyear on 22 Jul 22 - No Cached
  • Nathan Goodyear on 22 Jul 22
     
    Epinephrine increases LDH-A in breast cancer
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