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Anti-cancer peptides from ras-p21 and p53 proteins - PubMed - 0 views
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PNC-27 and 28, contain HDM-2-protein-binding domain sequences from the tumor suppressor p53 to induce pore formation in the membranes of a wide range of cancer cells but not any normal cells tested
Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells b... - 0 views
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PNC-27 induces pore formation in cancer cell membranes via the HDM-2 binding domain.
The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide - PubMed - 0 views
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Induces cell membrane lysis in MCF-7 cells.
Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Co... - 0 views
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PNC-27 selectively kills colon cancer stem cells by binding to membrane H/MDM-2. This was an in vivo study. As with other studies, the result was tumor cell necrosis and associated high LDH release.
Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal... - 0 views
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PNC-27 induces cancer cell necrosis via HDM-3 binding domain from p53, but not in non-malignant cells.
Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High... - 0 views
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PNC-27 binds to HDM-2 which is highly expressed on ovarian cancer cancer cell lines. The result is transmembrane pore formation and apoptosis independent cell necrosis.
Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian C... - 0 views
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PNC-27 found to be adjunctive with weekly paclitaxel in vivo model in ovarian cancer.
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