small study of oxytocin in children with autism. Shows that oxytocin provided benefit in social interaction/function. This study actually correlated MRI and salivary changes with the improve social function.
Worldwide, the rate of autism has been steadily rising.
Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism
There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome.
Other factors that have been considered include: maternally derived antibodies, maternal infection, heavy metal exposure, folic acid supplementation, epigenetics, measles, mumps, rubella vaccination, and even electromagnetic radiation.
lengthy but extremely thorough explanation of excitotoxicity and Autism. This is heavily referenced and should be read by all! A good discussion on how immune stimulation in the developing brain contributes to ASD...hint: vaccines.
Government review of trends of states reporting on Autism incidence/prevalence. The question, is why are not all of the state following this? Especially Louisiana and Mississippi.
Vitamin D deficiency may play a role in autism. Though this may seem logical, through NF-KappaB inhibition, the mode of protection may be more in pregnancy. I believe that the in-utero environment is setting up our children for increased ASD rates. Then add in the manner in which we treat our children as infants with massive vaccinations.
Study shows that gastrointestinal epithelial dysfunction is found in autism. This would play a critical role in systemic inflammation and would contribute to ASD symptoms through the gut-brain connection.
This case study shows the link between gastrointestinal inflammation and the brain. This case is of a child diagnosed with autism that recovered once a gluten free diet was instituted.