Skip to main content

Home/ Dr. Goodyear/ Group items tagged vitamin A

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Glutathione Redox Regulates Airway Hyperresponsiveness and Airway Inflammation in Mice ... - 0 views

www.atsjournals.org/...rcmb.2006-0423OC

glutathione asthma inflammation

shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • γ-GCE reduced levels of IL-4, IL-5, IL-10, and the chemokines eotaxin and RANTES (regulated on activation, normal T cell expressed and secreted) in bronchoalveolar lavage fluid, whereas it enhanced the production of IL-12 and IFN-γ.
  • γ-GCE suppressed eosinophils infiltration
  • γ-GCE directly inhibited chemokine-induced eosinophil chemotaxis
  • ...10 more annotations...
  • these findings suggest that changing glutathione redox balance, increase in GSH level, and the GSH/GSSG ratio by γ-GCE, ameliorate bronchial asthma by altering the Th1/Th2 imbalance through IL-12 production from APC and suppressing chemokine production and eosinophil migration itself.
  • Bronchial asthma is a typical helper T cell type 2 (Th2) disease
  • Through the release of Th2 cytokines, such as IL-4, IL-5, and IL-13, orchestrate the recruitment and activation of the primary effector cells of the allergic response: the mast cells and the eosinophils
  • Glutathione is the most abundant nonprotein sulfhydryl compound in almost all cells. This tripeptide plays a significant role in many biological processes. It also constitutes the first line of the cellular defense mechanism against oxidative injury along with SOD, ascorbate, vitamin E, and catalase, and is the major intracellular redox buffer in ubiquitous cell types
  • We have shown that glutathione redox status, namely the balance between intracellular reduced (GSH) and oxidized (GSSG) glutathione, in murine antigen-presenting cells (APC) plays a central role in determining which of the reductive and oxidative APC predominate during immune status, and the balance between reductive and oxidative APC regulates Th1/Th2 balance through production of IL-12
  • we have also shown that exposure of human alveolar macrophages to the Th1 cytokine IFN-γ or the Th2 cytokine IL-4 either increases or decreases the GSH/GSSG ratio, respectively, which regulates Th1/Th2 balance through IL-12 production
  • the ability to generate a Th1 or Th2 type response has turned out to depend not only on T cells but also on the intracellular glutathione redox status of APC
  • Th1 cytokine IFN-γ and Th2 cytokine IL-4 increases and decreases the GSH/GSSG ratio, respectively, and that this ratio influences LPS-induced IL-12 production from alveolar macrophages
  • the ability to generate a Th1 or Th2 response is dependent on glutathione redox status of APC
  • administration of γ-GCE elevates GSH level and GSH/GSSG ratio in the lung, and ameliorates AHR and eosinophilic airway inflammation by altering the Th1/Th2 balance and suppressing chemokine production and eosinophil migration in a mouse asthma model
  • Nathan Goodyear on 07 Jul 16
     
    glutathione redox reaction plays an important role in the ability to balance Th1 and Th2 and thus disease potential i.e. asthma as this study example.  
Justin Tantrum

Perfect Body Building Supplements - 3 views

I can honestly recommend Body Workshop Supplements to anyone who is aiming for a high quality protein source supplement. I have taken their offered product immediately after my work-out and it prov...

supplements

started by Justin Tantrum on 28 Mar 12 no follow-up yet
Nathan Goodyear

Deficiencies-graph.png 557×349 pixels - 0 views

assets.precisionnutrition.com/...Deficiencies-graph.png

nutrients malnutrition vitamins RDA USDA

shared by Nathan Goodyear on 17 Sep 17 - No Cached
  • Nathan Goodyear on 17 Sep 17
     
    RDA is not a great measure of individual nutrient need, but here is a 2009 USDA analysis of people not even meeting RDA.
Nathan Goodyear

Quantitative data on the magnitude of the systemic inflammatory response and its effect... - 0 views

www.ajcn.org/...64.abstract

inflammation micronutrients Vitamin A B-6 C D

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    As systemic inflammation goes up: the reliability of plasma micronutrients goes down.  The micronutrients listed in this study (Se, A, B-6, C and D) decreased as inflammation increased.  The take home is, the reliability of micronutrient testing must take into account inflammation
Edgar Anderson

Gaining Back My Good Health - 1 views

Due to my very hectic schedule at work there were several times that I skipped some meals and ate mostly canned foods or those that have preservatives. I thought it would not affect my health beca...

Dieticians

started by Edgar Anderson on 30 Aug 13 no follow-up yet
Nathan Goodyear

Omega Research - 0 views

www.omega-research.com/researchview.php

Omega-3 vitamin C E antioxidants oxidative stress infertility

shared by Nathan Goodyear on 15 Dec 10 - No Cached
  • These data have important implications for the supplementation of a combination of omega-3 fatty acids and antioxidants in the successful management of female infertility.
  • Nathan Goodyear on 15 Dec 10
     
    omega 3 and antioxidants aid in infertility
Nathan Goodyear

Ozone therapy: A clinical review - 0 views

www.ncbi.nlm.nih.gov/...PMC3312702

cancer Ozone

shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Its basic function is to protect humans from harmful effects of UV radiation
  • Its effects are proven, consistent and with minimal side effects
  • Medical O3, used to disinfect and treat disease, has been around for over 150 years
  • ...11 more annotations...
  • O3 not only remedied infection, but also had hemodynamic and anti-inflammatory properties
  • Stimulation of oxygen metabolism
  • In fungi, O3 inhibits cell growth at certain stages
  • With viruses, the O3 damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
  • Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone therapy disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins
  • Activation of the immune system
  • 30 and 55 μg/cc
  • production of interferon and the greatest output of tumor necrosis factor and interleukin-2
  • Mechanism of action of O3 on the human lung
  • cascade of reactions like peroxidation of lipids leading to changes in membrane permeability,[41] lipid ozonation products (LOP) act as signal transducer molecules
  • Dietary antioxidants or free radical scavengers like vitamin E, C, etc., can prevent aforementioned effects of O3
  • Nathan Goodyear on 13 Apr 20
     
    Ozone therapy review
Nathan Goodyear

Homocysteine and MTHFR Mutations - 0 views

circ.ahajournals.org/...e289.full

homocysteine MTHFR CVD cardiovascular death CAD c677T A1298c

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • The most common MTHFR mutation is called the MTHFR C677T mutation
  • Another common mutation is called MTHFR A1298C
  • Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation)
  • ...4 more annotations...
  • Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
  • Regardless of whether you have an MTHFR mutation in both genes or not, the treatment for elevated homocysteine is the same—dietary intervention and supplementation with folic acid and vitamins B6 and B12
  • Overall, evidence from these studies indicates that, so long as the homocysteine level is normal, MTHFR mutations do not significantly increase the risk of heart attack or stroke
  • Studies investigating the association of MTHFR mutations and venous blood clots have been inconsistent, with some studies showing a slight association, but most studies have not shown any association
  • Nathan Goodyear on 02 Feb 15
     
    Good review of MTHFR and homocysteine.
Nathan Goodyear

Folate | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...folate

Folate folic acid MTHFR micronutrients

shared by Nathan Goodyear on 23 Aug 15 - No Cached
  • Nathan Goodyear on 23 Aug 15
     
    Nice review on the difference b/t Folate and Folic acid.  Also, brief but worthy of a read, review of the MTHFR polymorphism 677.
Nathan Goodyear

https://onlinelibrary.wiley.com/doi/pdf/10.1002/1097-0142%2819900501%2963%3A9%3C1700%3A... - 0 views

onlinelibrary.wiley.com/...NCR2820630910%3E3.0.CO%3B2-%23

Hodgkin's lymphoma non-hodgkin's lymphoma lymphoma sarcoidosis vitamin D calcitriol hypercalcemia calcium

shared by Nathan Goodyear on 21 Aug 18 - No Cached
  • Nathan Goodyear on 21 Aug 18
     
    Hodgkin's and non-Hodgkin's lymphoma increase calcitriol production (1,25) similar to sarcoidosis.  This can lead to hypercalcemia.  This is a case study.
Nathan Goodyear

ingentaconnect Immunonutrition in Surgical Patients - 0 views

www.ingentaconnect.com/...art00009

immunonutrition surgery surgical patients

shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Surgery induces an inflammatory response
  • A range of nutrients, including several amino acids, antioxidant vitamins and minerals, ω-3 fatty acids, and nucleotides, are able to modulate inflammation and the associated oxidative stress, and maintain or improve immune function
  • parenteral glutamine is recommended in patients receiving parenteral nutrition
  • ...2 more annotations...
  • Antioxidants, particularly selenium, should be considered for critically ill patients
  • enteral formulas enriched with fish oils are recommended for patients with acute respiratory distress syndrome.
  • Nathan Goodyear on 21 Mar 11
     
    nutrition to improve inflammation in surgical patiens
Nathan Goodyear

Plasma Homocysteine as a Risk Factor for Vascular Disease, June 11, 1997, Graham et al.... - 0 views

jama.ama-assn.org/...1775.short

homocysteine CAD cardiovascular disease risk

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia. It powerfully increases the risk associated with smoking and hypertension. It is time to undertake randomized controlled trials of the effect of vitamins that reduce plasma homocysteine levels on vascular disease risk.
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine levels increase vascular disease risk.
Nathan Goodyear

Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Me... - 0 views

onlinelibrary.wiley.com/...abstract

vitamin D sun exposure mortality

shared by Nathan Goodyear on 16 Nov 14 - No Cached
  • Nathan Goodyear on 16 Nov 14
     
    Swedish Cohort finds low sun exposure is associated with increased mortality.
Nathan Goodyear

Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone and vit... - 0 views

pubmed.ncbi.nlm.nih.gov/25284545

LDN low dose naltrexone MET-5 MET-enkephalin cancer

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    LDN stimulates cytotoxicity via increase MET-enkephalin in cancer
« First ‹ Previous 321 - 340 of 349 Next ›
Showing 20▼ items per page