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Nathan Goodyear

Selenium modulates cancer cell response to pharmacologic ascorbate - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/35916672

IV vitamin C vitamin C cancer High dose IV vitamin C high dose vitamin C selenium

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    We dwficiency increases vitamin c cytotoxicity
Nathan Goodyear

Effect of high dose vitamin C on Epstein-Barr viral infection - 0 views

www.ncbi.nlm.nih.gov/...PMC4015650

IVC IV intravenous vitamin C IV vitamin C intravenous vitamin C vitamin C Epstein-Barr Epstein-Barr virus EBV viral infection

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    IV vitamin C shown to reduce EBV EA IgG and EBV VCA IgM using 7.5 grams to 50 gram infusions.  This protocol found that Magnesium reduced discomfort with the IVC therapy.
Nathan Goodyear

High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced ... - 0 views

stm.sciencemag.org/...222ra18

ovarian cancer IV vitamin C vitamin C intravenous vitamin C

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    IV vitamin C shown to augment cancer killer effect of chemotherapy.  This study looked at ovarian cancer in animal models and in humans.  The effect--a synergistic effect was found that promoted tumor destruction.  The great thing about IV vitamin C is the benefit but also the very low side effect profile.
Nathan Goodyear

Effect of high-dose intravenous vitamin C on inflammation in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC3480897

vitamin C vitamin C CRP inflammation cancer IV intravenous IV vitamin C Intravenous vitamin C

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    IV vitamin C reduces inflammation in cancer patients, primarily measure through CRP. 
Nathan Goodyear

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164

sepsis IV vitamin C vitamin C CRP

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
  • ...7 more annotations...
  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
Nathan Goodyear

[Full text] High-dose vitamin C suppresses the invasion and metastasis of breast c | OTT - 0 views

www.dovepress.com/-reviewed-fulltext-article-OTT

epithelial to mesenchymal transition EMT vitamin C cancer

shared by Nathan Goodyear on 08 Mar 21 - No Cached
  • Nathan Goodyear on 08 Mar 21
     
    Vitamin C Inhibits EMT
Nathan Goodyear

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of a... - 0 views

www.sciencedirect.com/...S0891584916304087

hypoxia VEGF HIF-1alpha vitamin C HIF-1 cancer GLUT

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Very nice mouse study. They reduced hypoxia signialing, HIF-1alpha, via daily vitamin C administration. Also a very interesting point, that the vitamin C had a much longer half life within the tumor than normal tissue-up to 48 hours compared to 30 minutes in normal. So, that begs the question, what does higher dose do? In this study they also saw a reduction in angiogenesis and tumor growth.
Nathan Goodyear

Effect of High-dose Vitamin C Combined With Anti-cancer Treatment on Breast Cancer Cells - 0 views

ar.iiarjournals.org/...751.short

vitamin c breast cancer

shared by Nathan Goodyear on 20 Aug 19 - No Cached
  • Nathan Goodyear on 20 Aug 19
     
    cell study finds high dose vitamin C (up to 20 mM) augments conventional chemo.
Nathan Goodyear

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model - 0 views

www.ncbi.nlm.nih.gov/...PMC6983418

check point inhibitors CTL lymphoma cytotoxic T cells PD-1 vitamin C immune check point inhibitors IV vitamin C NK cells NK

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    high dose vitamin C shown to augment PD-1 immune check point inhibitors in Lymphoma mouse model.
Nathan Goodyear

Effect of Intravenous High Dose Vitamin C on Postoperative Pain and Morphine Use after ... - 0 views

www.hindawi.com/...9147279

vitamin C morphine surgery pain

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    This study shows high dose vitamin C infusion decreased postoperative pain during the first 24 h and reduced morphine consumption in the early postoperative period.
Nathan Goodyear

Effect of high-dose intravenous vitamin C on inflammation in cancer patients - 0 views

www.translational-medicine.com/...1479-5876-10-189.pdf

IV vitamin C IV intravenous vitamin C antioxidant antioxidants inflammation IL-1 IL-2 IL-8 TNF-alpha CRP cytokines

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    In this small study, IV vitamin C up to 50 grams shown to reduce inflammation in cancer patients. The inflammatory cytokines reduced were: IL-1alpha, crp, IL-2, IL-8, and TNF-alpha.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.cmaj.ca/...937.full.pdf+html

IV vitamin C IV intravenous vitamin C cancer

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    3 case studies on high dose IV vitamin C in cancer treatment.
Nathan Goodyear

PLOS ONE: Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practiti... - 0 views

www.plosone.org/...journal.pone.0011414

IV vitamin C vitamin C intravenous alternative medicine complementary alternative

shared by Nathan Goodyear on 29 Sep 13 - No Cached
  • Nathan Goodyear on 29 Sep 13
     
    Rare side effects of high dose vitamin C.  Proven to be very safe compared to even labeled use of FDA approved drugs.
Nathan Goodyear

Phase I clinical trial of i.v. ascorbic acid in ad... [Ann Oncol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/pubmed

IV vitamin C vitamin C intravenous IV vitamin C cancer

shared by Nathan Goodyear on 02 Oct 13 - No Cached
  • Nathan Goodyear on 02 Oct 13
     
    High dose IV vitamin C not proven to be effective in patients with advanced cancer, but proven to be very safe.
Nathan Goodyear

Urinary glucose and vitamin C. [Am J Clin Pathol. 1977] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...920657

Vitamin C DM diabetes

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • vitamin C added, false-positive tests for glucose were found
  • Nathan Goodyear on 13 Jul 11
     
    high dose vitamin C causes false positive glucose elevations
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