Glyphosate, component of Roundup is well known to be an endocrine disruptor. This rat study describes the mechanism of disruption of the Sertoli cells resulting in male infertility. In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification. If that is not enough, oxidative damage marker TBARS was elevated.
glyphosate increases ER-alpha expression and activation though this study found no evidence that glyphosate bound to ER-alpha. This makes glyphosate a endocrine disrupter.
Probably one of the more disturbing aspects of glyphosate exposure. In utero exposure, lowers Testosterone levels and effects the masculinization process of the young boy. Very disturbing. Our boys are being altered before they are even born.
one can conclude that ERβ has an overall antiproliferative effect, thereby inhibiting cancer cell
proliferation and antagonizing ERα function in the breast
HRT with estrogen alone did not increase the risk of breast cancer in the
Women's Health Initiative clinical trials program
colorectal normal or cancer epithelium does not coexpress ERα and ERβ
ERβ expression resulted in the inhibition of proliferation and G1 phase cell-cycle arrest
ERβ
expression strongly inhibited cMyc and tumor growth in a xenograft mouse model
induced ERβ in CRC
cells has an antiproliferative, tumor-suppressive function that is independent of ERα
ERs also have the ability to bind many other compounds with an estrogen-like structure, including phytoestrogens
and xenoestrogens (or endocrine disruptors)
Phytoestrogens are a diverse class of natural compounds with structural similarity to estradiol
Barone et al. recently found that two ERβ-selective
phytoestrogens effectively counteracted CRC tumorigenesis and surprisingly increased ERβ expression in mice with mutations
of the tumor-suppressor gene adenomatous polyposis coli
We can conclude that estrogens are important in protecting against CRC initiation and progression, and that the protective
effect most likely is mediated by ERβ