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Nathan Goodyear

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells thro... - 0 views

onlinelibrary.wiley.com/...jso.21392

LPS cancer pancreatic cancer NF-kappaB

shared by Nathan Goodyear on 10 Jan 21 - No Cached
  • Nathan Goodyear on 10 Jan 21
     
    Lipopolysaccharide (LPS) activates Toll-like 4 receptors (TLR-4) to increase cancer invasion, growth, and metastasis.
Nathan Goodyear

Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging - 0 views

www.ncbi.nlm.nih.gov/...PMC4311182

LPS Toll-like receptors toll like receptors TLR-4 metabolic endotoxemia TLR4

shared by Nathan Goodyear on 24 Jan 22 - No Cached
  • Nathan Goodyear on 24 Jan 22
     
    Not a direct cause and effect, but a clear associated between metabolic endotoxemia and increase in TLR4
Nathan Goodyear

A TRIFfic Perspective on Acute Lung Injury: Cell - 0 views

www.cell.com/...S0092-8674(08)00454-6

toll-like receptors cytokine storm SARS pattern recognition receptors MERS IL-6 PRR TLR4

shared by Nathan Goodyear on 19 May 20 - No Cached
  • Nathan Goodyear on 19 May 20
     
    Recognition of TLR4 PRR involvement in cytokine storm from SARS all the way back to 2008. Md88 and TRIF involved.
Nathan Goodyear

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up - 0 views

endo.endojournals.org/...4109.full

inflammation obesity overweight hypothalamus HPA

shared by Nathan Goodyear on 04 Oct 12 - No Cached
  • Leptin, secreted by adipocytes in proportion to body fat mass
  • The saturated fatty acid palmitate (16:0) induces NF-κB signaling through a TLR4-dependent mechanism
  • 18:0 (stearic) and longer saturated fatty acids as well as linolenic acid (18:3) increased proinflammatory cytokines, ER stress markers, and TLR4 activation
  • ...6 more annotations...
  • (SOCS)-3. A member of a protein family originally characterized as negative feedback regulators of inflammation (13, 37), SOCS3 inhibits insulin and leptin signaling
  • IKKβ signaling in discrete neuronal subsets appears to be required for both hypothalamic inflammation and excess weight gain to occur during HF feeding
  • the paradoxical observation that hyperphagia and weight gain occur when hypothalamic inflammation is induced by HF feeding, yet when it occurs in response to systemic or local inflammatory processes (e.g. administration of endotoxin), anorexia and weight loss are the rule
  • , serves as a circulating signal of energy stores in part by providing feedback inhibition of hypothalamic orexigenic pathways [e.g. neurons that express neuropeptide Y and agouti-related peptide (AgRP)]
  • and stimulating anorexigenic neurons
  • signals from Toll-like receptors (TLRs), evolutionarily conserved pattern recognition molecules critical for detecting pathogens, amplified through signaling intermediates such as MyD88 activate the inhibitor of κB-kinase-β (IKKβ)/nuclear factor-κB (NF-κB), c-Jun N-terminal kinase (Jnk) and other intracellular inflammatory signals in response to stimulation by circulating saturated fatty acids
  • Nathan Goodyear on 04 Oct 12
     
    great read on the current understanding of how obesity and resultant inflammation disrupts hypothalamic function.
Nathan Goodyear

Histochemistry and Cell Biology, Volume 127, Number 2 - SpringerLink - 0 views

www.springerlink.com/...yj35n4j531j67211

TLR TLR-4 toll-like receptors inflammtion obesity LPS lipopolysaccharides

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    Abstract only, but this study shows that the innate immunity plays a role in the development of obesity through the TLR.  LPS was shown to stimulate the inflammatory cascade through the TLRs
Nathan Goodyear

TLR Signaling in the Gut in Health and Disease - 0 views

www.jimmunol.org/...4453.full

TLR toll-like receptors gut inflammation disease health

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    How the gut contributes to inflammation and disease: through TLR.
Nathan Goodyear

The intestinal epithelial barrier: how to dist... [Semin Immunol. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17324587

TLR toll-like receptors NODs GI gut immunity inflammation microbiota bacteria dysbiosis

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    TLRs and NODs play important role in GI mucosal immunity.
Nathan Goodyear

BACTERIAL INTERACTIONS WITH CELLS OF THE INTESTINAL MUCOSA: TOLL-LIKE RECEPTORS AND NOD... - 0 views

gut.bmj.com/...1182.long

gut bacteria microbiota dysbiosis health GI TLRs NODs

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    How interactions between the bacteria, both commensal and pathogenic, occur.  This can precipitate disease or promote health.  This occurs through TLRs and Nods
Nathan Goodyear

Benign prostatic hyperplasia: a new meta... [J Endocrinol Invest. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24458832

BPH benign prostatic hypertrophy Toll-like receptors TLRs hormone hormones low Testosterone T estrogen estradiol aromatase prostate metabolism

shared by Nathan Goodyear on 20 Feb 14 - No Cached
  • Nathan Goodyear on 20 Feb 14
     
    The authors of this paper describe BPH as a metabolic disease: involving inflammation with increased expression of TLRs, hormone imbalance and altered metabolism
Nathan Goodyear

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals corre... - 0 views

www.ncbi.nlm.nih.gov/...PMC2833250

colon cancer colorectal cancer cancer LPS lipopolysaccharides

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    High TLR4 and MyD88 expression on the surface of colorectal cancer cells associated with increase liver mets potential and worsened prognosis.  LPS works through TLR4 and MyD88.
Nathan Goodyear

Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory abilit... - 0 views

www.sciencedirect.com/...S0039606013001050

LPS lipopolysaccharides cancer

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    LPS stimulation induced increased mets potential in esophageal cell culture study.
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