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"Previous research on rhesus macaques discovered that social rank influenced components of the stress response, brain, and immune system. With gene chip technology for measuring the expression of over 6,000 different genes, Tung, Gilad and colleagues at Yerkes, Emory University, and Johns Hopkins looked for the first time in primates at the effects of social rank on genetic function. Comparing 49 different female monkeys of different rank revealed significant changes in the expression of 987 genes, including 112 genes associated with immune system function. The result fits with data in monkeys where low rank and chronic stress lead to compromised immune function, and, more loosely, with human studies linking low socioeconomic status and high social stress to elevated disease risk."

"We provide novel evidence for the effects of metabolic dysfunctions on brain function using the rat model of metabolic syndrome induced by high fructose intake. * We describe that the deleterious consequences of unhealthy dietary habits can be partially counteracted by dietary supplementation of n-3 fatty acid. * High sugar consumption impaired cognitive abilities and disrupted insulin signalling by engaging molecules associated with energy metabolism and synaptic plasticity; in turn, the presence of docosahexaenoic acid, an n-3 fatty acid, restored metabolic homeostasis. * These findings expand the concept of metabolic syndrome affecting the brain and provide the mechanistic evidence of how dietary habits can interact to regulate brain functions, which can further alter lifelong susceptibility to the metabolic disorders. "

Open Economics Working Group is run by the Open Knowledge Foundation in association with the Centre for Intellectual and Property Law (CIPIL) at the University of Cambridge. Its membership consists of leading academics and researchers, public and private sector economists, representatives from national and international public bodies and other experts from around the world.

In another study, in which volunteers saw the same pictures while having their brain scanned using MRI, she found that people had a stronger response in the hippocampus and amygdala - areas of the brain associated with fear - when they were shown fearful faces at systole than when they saw them at diastole. In other words, half a heartbeat was all it took for a person to experience a significantly different response to the same scary stimulus.

""We probably have underestimated the role our microbial flora play in modulating disease risk," says Daniel Rader, a heart disease specialist at the University of Pennsylvania School of Medicine. Rader, who was not involved in the study, says that gut bacteria may not be as big a factor in causing heart disease as diabetes or smoking, but could be important in tipping some people toward sickness. Researchers led by Stanley Hazen, a cardiologist at the Cleveland Clinic, didn't start out to study gut bacteria. In fact, says Hazen, he had "no clue - zero," that intestinal microbes were involved in heart disease. "I'd never even considered it or thought of the concept." Hazen and his colleagues compared blood plasma from healthy people to plasma from people who had had heart attacks, strokes or died to see if substances in the blood could predict who is in danger from heart disease. The researchers found 18 small molecules associated with fat buildup in the arteries. One of the best predictors turned out to be a byproduct made when gut bacteria break down a fat called choline (also known as lecithin). The more of this byproduct, called trimethylamine N-oxide or TMAO, a person or mouse has in the blood, the higher the risk of getting heart disease, the researchers found. Gut bacteria are actually middlemen in TMAO production. The microbes convert lecithin to a gas that smells like rotten fish. Then an enzyme in the liver changes the foul-smelling gas to TMAO."

"Emily Zu-Yin Chen vom Veterans Hospital in Taipeh kürzlich auf einem Kongress der American Heart Association in Orlando berichtete. Mehr als 102.000 Krankenakten von Erwachsenen hat die Kardiologin untersucht, die bis zum Jahr 2000 keinen Schlaganfall oder Herzinfarkt gehabt hatten. Knapp die Hälfte der Teilnehmer ließ sich in den folgenden sieben Jahren mindestens einmal beim Zahnarzt den Zahnstein entfernen, die andere Hälfte nicht."

Has a cheap and effective treatment for chronic pain been lying under clinicians' noses for decades? Researchers have found that a very high dose of an opiate drug that uses the same painkilling pathways as morphine can reset the nerve signals associated with continuous pain - at least in rats. If confirmed in humans, the procedure could reduce or eliminate the months or years that millions of patients spend on pain-managing prescription drugs. The results of the study are described today in Science1.

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"Leah Pyter: Well basically what we know is that patients with cancer have a higher likelihood of also developing depression at some point in their disease progression, so whether that occurred before and is predisposing them to cancer, or it's due to the tumours themselves, or other aspects of having the disease, we don't know. We were only studying right now whether the cancer itself can cause depression. Chris Smith: How could a tumour trigger depression, because a tumour can occur anywhere in the body, therefore at the remote sites in the brain, so how could it trigger changes in brain activity? Leah Pyter: Sure, well what we hypothesized was that the tumours themselves can produce cytokines which has been shown before. Chris Smith: These are inflammatory chemicals that drive the immune system? Leah Pyter: Right, exactly! And there is also a pile of research on how cytokines can access the brain specifically regions of the brain that are associated with depression and anxiety and emotional behaviours, and they can access the brain both tumourally through the blood, or neurally through the vegas nerves. "

"Individuals who are homozygous for the G allele of the rs53576 SNP of the oxytocin receptor (OXTR) gene tend to be more prosocial than carriers of the A allele. However, little is known about how these differences manifest behaviorally and whether they are readily detectable by outside observers, both critical questions in theoretical accounts of prosociality. In the present study, we used thin-slicing methodology to test the hypotheses that (i) individual differences in rs53576 genotype predict how prosocial observers judge target individuals to be on the basis of brief observations of behavior, and (ii) that variation in targets' nonverbal displays of affiliative cues would account for these judgment differences. In line with predictions, we found that individuals homozygous for the G allele were judged to be more prosocial than carriers of the A allele. These differences were completely accounted for by variations in the expression of affiliative cues. Thus, individual differences in rs53576 are associated with behavioral manifestations of prosociality, which ultimately guide the judgments others make about the individual. "

"During wakefulness, we are always conscious of ourselves. In sleep, however, we are not. But there are people, known as lucid dreamers, who can become aware of dreaming during sleep. Studies employing magnetic resonance tomography (MRT) have now been able to demonstrate that a specific cortical network consisting of the right dorsolateral prefrontal cortex, the frontopolar regions and the precuneus is activated when this lucid consciousness is attained. All of these regions are associated with self-reflective functions. This research into lucid dreaming gives the authors of the latest study insight into the neural basis of human consciousness."

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"Social interactions require fast and efficient person perception, which is best achieved through the process of categorization. However, this process can produce pernicious outcomes, particularly in the case of stigma. This study used fMRI to investigate the neural correlates involved in forming both explicit ("Do you like or dislike this person?") and implicit ("Is this a male or female?") judgments of people possessing well-established stigmatized conditions (obesity, facial piercings, transsexuality, and unattractiveness), as well as normal controls. Participants also made post-scan disgust ratings on all the faces that they viewed during imaging. These ratings were subsequently examined (modeled linearly) in a parametric analysis. Regions of interest that emerged include areas previously demonstrated to respond to aversive and disgust-inducing material (amygdala and insula), as well as regions strongly associated with inhibition and control (anterior cingulate and lateral prefrontal cortex). Further, greater differences in activation were observed in the implicit condition for both the amygdala and prefrontal cortical regions in response to the most negatively perceived faces. Specifically, as subcortical responses (e.g., amygdala) increased, cortical responses (e.g., lateral PFC and anterior cingulate) also increased, indicating the possibility of inhibitory processing. These findings help elucidate the neural underpinnings of stigma"

Susanna Larsson: Kaffeetrinkerinnen haben ein geringeres Risiko für Hirninfarkte http://www.wissenschaft.de/wissenschaft/news/313141.html (Jingmei Li, Karolinska Institutet, et al.: Breast Cancer Research, Bd. 13, Artikel R49) Yvonne T. van der Schouw (UMC Utrecht) et al.: Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, doi: 10.1161/ATVBAHA.109.201939 http://www.wissenschaft.de/wissenschaft/news/311350.html Helena Jernström: Kaffee senkt das Brustkrebsrisiko http://www.wissenschaft.de/wissenschaft/gutzuwissen/291553.html

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"The WorldCat knowledge base combines data about your library's electronic resources and linking features that enable access to the content and help you manage the workflows associated with these materials. Unlike data in a traditional knowledge base, WorldCat knowledge base data is not tied to a particular application. Knowledge base data is added and maintained in a single place for use with a growing number of OCLC and non-OCLC services."

"And again, in this expanded group, she found the same association between the variation of the DRD4 gene and a willingness to take risks on the slopes. The variant's overall effect was slight, explaining only about 3 percent of the difference in behavior between risk takers and the risk averse, but was statistically significant and remained intact"