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Has a cheap and effective treatment for chronic pain been lying under clinicians' noses for decades? Researchers have found that a very high dose of an opiate drug that uses the same painkilling pathways as morphine can reset the nerve signals associated with continuous pain - at least in rats. If confirmed in humans, the procedure could reduce or eliminate the months or years that millions of patients spend on pain-managing prescription drugs. The results of the study are described today in Science1.

Unlike most beverages, grapefruit juice contains a chemical that boosts the potency of many drugs in the body. To avoid a dangerously high dose of medication, patients are often advised to not wash down pills with grapefruit juice.