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Has a cheap and effective treatment for chronic pain been lying under clinicians' noses for decades? Researchers have found that a very high dose of an opiate drug that uses the same painkilling pathways as morphine can reset the nerve signals associated with continuous pain - at least in rats. If confirmed in humans, the procedure could reduce or eliminate the months or years that millions of patients spend on pain-managing prescription drugs. The results of the study are described today in Science1.

"uBiome is a citizen science project that allows the public access to cutting edge sequencing technology to understand their health through the microbiome. How does the microbiome affect my health? We are all covered in trillions of microbes -- in fact, they outnumber human cells 10:1. The trillions of bacteria live on and in us are collectively called the microbiome. Like the rainforest, the healthy human microbiome is a balanced ecosystem. The correct balance of microbes keeps potential pathogens in check and regulates our immune system. Microbes also perform essential functions such as digesting food and synthesizing vitamins. Studies have also linked the microbiome to human mood and behavior, as well as many gut disorders, eczema, and chronic sinusitis."

"When the right microorganisms are at work, immune cells involved in the development of autoimmune illnesses like psoriasis, multiple sclerosis and arthritis, can develop anti-inflammatory properties. Scientists at Charité - Universitätsmedizin Berlin and the Institute for Research in Biomedicine, Bellinzona, Switzerland, have now made this discovery. Their work is published in the current issue of the scientific journal Nature*. The scientists were able to prove that particular fungi activate the immune cells involved in the development of certain illnesses, whereas other microorganisms, in particular bacteria that are found naturally on our skin, lend an anti-inflammatory function to them. "This not only demonstrates that the composition of our microflora has a decisive role in the development of chronic illnesses, but also that the key cells causing illness can develop an anti-inflammatory 'twin'," explained Dr. Christina Zielinski, first author of the study."

"Previous research on rhesus macaques discovered that social rank influenced components of the stress response, brain, and immune system. With gene chip technology for measuring the expression of over 6,000 different genes, Tung, Gilad and colleagues at Yerkes, Emory University, and Johns Hopkins looked for the first time in primates at the effects of social rank on genetic function. Comparing 49 different female monkeys of different rank revealed significant changes in the expression of 987 genes, including 112 genes associated with immune system function. The result fits with data in monkeys where low rank and chronic stress lead to compromised immune function, and, more loosely, with human studies linking low socioeconomic status and high social stress to elevated disease risk."

"For me, the picture that emerges is one in which chronic inflammation caused by poor oral health sets the stage for more serious illness. (See my earlier post for more info about the connection between inflammation and cancer.) I think further research will probably turn up some surprising connections between oral bacteria and cancer, but we don't have to wait for additional research to begin taking oral hygiene seriously as a potential way to head off cancer and CVD."

"So far the treatment, known as faecal transplant, has been tested only on a drug resistant form of the bowel disease caused by the bacterium clostridium difficile. Antibiotics are unreliable against the superbug, but the transplant is 95% successful, saving patients from constant stomach cramps and chronic diarrhoea. "It sounds radical but it makes a lot of sense," said Seppelt on Thursday at a gathering of more than 4,000 Australasian anaesthetists and surgeons. "Usually patients are sufficiently miserable to go ahead, often using a donation from a relative." Healthy humans have about 100 times more bacteria cells in their gut than their own cells."