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"Derived from the root of the plant. This supplement is used in traditional Chinese medicine primarily for gastrointestinal complaints, diarrhea, hypertension, bacterial and viral infections. Berberine and berberine-like alkaloids are thought responsible for its activity (1). Laboratory studies indicate that berberine induces morphological changes and internucleosomal DNA fragmentation in hepatoma cancer cells (3). Preliminary data support the hypothesis that huanglian suppresses cyclin B1 protein and causes cell cycle arrest at G2 (5). Huanglian has potent antiangiogenesis activity (6). It also interacts with acetylcholine and muscarinic receptors and inhibits cholinesterase. Possible adverse effects include nausea and vomiting (1). Theoretically huanglian may have additive hypotensive effects with antihypertensive agents. A phase I dose escalation study of huanglian in solid tumors is currently underway at Memorial Sloan-Kettering Cancer Center based on"

"I discussed in my last post how Dr Vieth has a model of tissue 1,25(OH)2D synthesis and degradation in which the level of active substance is pretty well independent of blood vitamin D level, provided the level is either rising or stable. I think it is also worth pointing out that he is talking, hypothetically, about tissue 1,25(OH)2D, not plasma level... As we know, almost nothing is known about tissue 1,25(OH)2D control. By Vieth's hypothesis tissue 1,25(OH)2D is OK so long as there is at least SOME vitamin D present in plasma and the level dose not vary too much. Obviously there is a level below which you can have as much of the enzyme for converting vitamin D to the active form as you like, if there is no vitamin D in your blood you can't make any 1,25(OH)2D in your tissues, or in your kidneys for export to your blood to control calcium levels. At the lower extremes we have rickets and osteomalacia. These are clear cut, unarguable markers of vitamin D deficiency, in the absence of confounding factors (there are a few)."

Vitamin D, nervous system and aging. P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. . Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286 NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION doi:10.1016/j.psyneuen.2009.07.003 This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.

Phytase activity in the human and rat small intestine. Iqbal TH, Lewis KO, Cooper BT. Gut. 1994 Sep;35(9):1233-6. PMID: 7959229

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes.[1] PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis[2] of higher organism.

Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. Jiang F, Bao J, Li P, Nicosia SV, Bai W. J Biol Chem. 2004 Dec 17;279(51):53213-21. Epub 2004 Oct 12. PMID: 15485861 doi: 10.1074/jbc.M410395200 Overall, the study suggests that the down-regulation of telomerase activity by 1,25(OH)2VD3 and the resulting cell death are important components of the response of OCa cells to 1,25(OH)2VD3-induced growth suppression. Progressive shortening of telomere associated with cell divisions limits the life span of normal cells and eventually leads to senescence. To become immortal, human cancers including OCa are invariably associated with activation of mechanism that maintains telomere length. Approximately 85-90% of cancers show reactivation of telomerase. The present study shows that telomerase in OCa cells is down-regulated by 1,25(OH)2VD3. Down-regulation of telomerase is due to decreased stability of hTERT mRNA rather than VDRE-mediated transcriptional repression through the putative VDRE present in the regulatory region of the hTERT gene. It is known that the inhibition of telomerase may lead to a phenotypic lag during which cells would continue to divide until the point at which the telomeres became critically short. This phenomenon may explain why the apoptotic induction by 1,25(OH)2VD3 needs the treatment for more than 6 days. As mentioned in the results, no detectable shortening of telomeric repeats was observed in parental OVCAR3 cells after 9 days of treatment with 1,25(OH)2VD3 (Fig. 4D). This is likely due to the fact that the short telomere (about 3 kb) in OVCAR3 cells is very close to the minimal length required for survival and that cells with detectably shorter telomere may have been selected against apoptosis. It has been shown that transformed human cells enter crisis once the terminal restriction fragment of the telomere reaches a length of about 4 kb. This is insufficient to protect chro

"Hypovitaminosis D is a deficiency of Vitamin D. It can result from: inadequate intake coupled with inadequate sunlight exposure (in particular sunlight with adequate ultra violet B rays), disorders that limit its absorption, conditions that impair conversion of vitamin D into active metabolites, such as liver or kidney disorders, or, rarely, by a number of hereditary disorders.[1] Deficiency results in impaired bone mineralization, and leads to bone softening diseases, rickets in children and osteomalacia in adults, and contributes to osteoporosis.[1] Osteomalacia may also occur rarely as a side-effect of phenytoin use Hypovitaminosis D is typically diagnosed by measuring the concentration in blood of the compound 25-hydroxyvitamin D (calcidiol), which is a precursor to the active form 1,25-dihydroxyvitamin D (calcitriol).[6] One recent review has proposed the following four categories for hypovitaminosis D:[7] * Insufficient 50-100 nmol/L (20-40 ng/mL) * Mild 25-50 nmol/L (10-20 ng/mL) * Moderate 12.5-25.0 nmol/L (5-10 ng/mL) * Severe < 12.5 nmol/L (< 5 ng/mL) Note that 1.0 nmol/L = 0.4 ng/mL for this compound.[8] Other authors have suggested that a 25-hydroxyvitamin D level of 75-80 nmol/L (30-32 ng/mL) may be sufficient

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG, Chung JG. Cancer Lett. 2009 Jul 8;279(2):155-62. Epub 2009 Feb 28. PMID: 19251361 doi:10.1016/j.canlet.2009.01.033 There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of berberine on migration and invasion of human tongue cancer cells. Here, we report that berberine inhibited migration and invasion of human SCC-4 tongue squamous carcinoma cells. This action was mediated by the p-JNK, p-ERK, p-p38, IκK and NF-κB signaling pathways resulting in inhibition of MMP-2 and -9 in human SCC-4 tongue squamous carcinoma cells. Our Western blowing analysis also showed that berberine inhibited the levels of urokinase-plasminogen activator (u-PA). These results suggest that berberine down-regulates u-PA, MMP-2 and -9 expressions in SCC-4 cells through the FAK, IKK and NF-κB mediated pathways and a novel function of berberine is to inhibit the invasive capacity of malignant cells.

It is a scientific fact that the type of food you eat influences your brain activity. Therefore, foods have a certain affect not only on the physical health, but also on the mental health of human beings. As humans age, all body processes start slowing down, thereby affecting the performance of an individual. However, with the use of healthy and smart foods, individuals can enhance their brain activity and sharpen their memory and focus.

Now food Zinc Gluconate 50 mg, 250-Count for of its insufficiency: Zinc may be used for treatment in addition to deterrence with regard to zinc deficit & it's final results, for example reduced improvement in addition to serious diarrhea inside children, in addition to slow damage recuperation. Zinc for enhancing the body protection System: It's furthermore useful for enhancing the particular disease fighting capability, working most abundant in well-liked frosty in addition to repetitive listening to transmissions, in addition to preventing decrease breathing transmissions. It's furthermore useful for malaria as well as other ailments due to undesirable microorganisms. Now food Zinc Gluconate 50 mg, 250-Count, for the Muscle wellness: Lots of people take advantage of zinc to have interest sickness referred to as muscle destruction, with regard to night lack of view, in addition to regarding cataracts. It's furthermore useful for asthma; diabetes; greater blood stream tension; acquired immunodeficiency condition (AIDS); in addition to skin pores & pores and skin difficulties, for instance psoriasis, eczema, in addition to pimples. Zinc for the entire body illnesses, problems: Extra makes use of contain coping with curiosity deficit-hyperactivity situation (ADHD), blunted sensation related to taste (hypogeusia), ringing in the ears (tinnitus), severe thoughts accidents, Crohn's sickness, Alzheimer's sickness, Reduce condition, Hansen's sickness, ulcerative colitis, peptic ulcers in addition to marketing lbs acquire inside people with eating difficulties for instance anorexia nervosa. Now food Zinc Gluconate 50 mg, 250-Count, with regard to male fertility & your own reproductive system program: Lots of people take advantage of zinc regarding safe prostatic hyperplasia (BPH), guy infertile, hard-on disorder (ED), delicate navicular bone (osteoporosis), rheumatoid arthritis symptoms signs and symptoms, in addition to muscle tissue cramps asso

Mango is a summer delicacy which is consumed worldwide. They are juicy, sweet and act as a natural coolant which is very effective in beating the summer heat. Many varieties of mango are available in the market which have different taste and flavors. They are usually consumed raw and are savored in fresh salads and juices. Mango shakes, pickles, sauces, ice-creams and smoothies are prepared from mangoes which provide different blend of flavor to them. Let us find out the nutritional and health benefits of mango. Nutritional Benefits of Mango Juice provides around 60 calories for 100 grams of its serving. It contains a lot of phytochemicals and nutrients and is a rich source of carbohydrates and fibre. Antioxidants and Vitamins like Vitamin-A, B, C, E and K are present in it. Mango is also a good source of various minerals like Calcium, Zinc, Potassium, Iron, Magnesium and Potassium. Some Main Benefits of Mango Juice - Beneficial for Prevents Cancer: Mangoes are rich in antioxidants which restrict the oxidation of cells in the body. These antioxidants are quercetin, isoquercitrin, astragalin, fisetin, gallic acid and methylgallat. Even Vitamin-A and flavonoids like beta-carotene, alpha-carotene, and beta-cryptoxanthin present in mango prevents lung and oral cancer. Improves Brain and Health Memory: Mango Juice in Vitamin-B6 is found in abundance in mango which helps in improving brain function. It helps in maintaining an efficient nervous system. It is a mood vitamin and enhances mood and controls stress. Beneficial for Aids Digestion: Mangoes are a rich source of dietary fibre which helps in proper digestion. Fibres help with proper bowel movement and keep the digestive tract clean. Mangoes are alkaline in nature thus reduce acidity in the stomach. Various bio-active compounds like Esters, Terpenes and Aldehydes make mangoes even more potent against indigestion. Lowering Cholesterol: Mango Juice are rich in fibre which reduce bad choleste

Mango is one of the delicious tropical seasonal fruit and believed to be originated in the sub-Himalayan plains of Indian subcontinent.It is Maintains cancers, Blood Pressure and heart conditions and more.

Mango juice contains the vital nutrient, potassium that assists your muscles, heart and nerves' functions. This advantageous mineral also regulates the balance of fluids in your body and your blood pressure.

Mangoes is a seasonal fruit has been a regular part of human diet for about four thousand years, thanks to its unique flavour, taste and fragrance. You would also have relished this fruit but do you know the benefits of mango?

Mangoes have an impressive vitamin content that assures overall health. They are rich in potassium (4% in 156 mg) and magnesium (2% in 9 mg), and mango juice are great natural remedies for high blood pressure patients. They also contain selenium, calcium, iron and phosphorus. Mangoes are said to be vitamin powerhouses as they are rich in riboflavin, vitamin B6, A, C, E, K, niacin, folate, thiamin and panthothenic acid. These components help you to avoid a host of diseases that can come from deficiencies of these vitamins and minerals. The vitamin E content in mangoes can even help to boost your sex life by triggering the activity of your sex hormones.

Research and studies published at Comprehensive Reviews in Food Science and Food Safety have demonstrated that dietary fiber has a positive effect on eliminating degenerative diseases, including certain cancers,Blood Pressure and heart conditions. Now you have even more reasons to include this delicious fruit in your daily diet. The more you participate in strenuous activities,the more bodily potassium you lose, which is yet another helpful side effects of mangoes - high potassium content!

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In a pilot test, the program helped children reduce body mass index, achieve more muscle mass, improve their health-related quality of life, reduce screen time, and increase levels of physical activity.

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A lot of individuals now are becoming customers of Kingly Velvet and it deer antler supplement products. Still on doubt with its effectiveness? How about giving it a test yourself? Enjoy life as you are on your way to a healthy and active body.

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Read Kingly Velvet Antler Velvet reviews today and let it be a basis to purchase one of these amazing supplements that will keep you healthy and active. Start having a healthy lifestyle today without any regrets.

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